Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination – JUNE-2019
Time: Three Hours Max. Marks: 75 Marks
Pharmacology - I
Q.P. CODE: 5016
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
1. Explain about different routes of drug administration.
2. Write the principle and mechanism of drug action.
3. Describe the neurohumoral transmission with examples.
SHORT ESSAYS (Answer any Seven) 7 x 5 = 35 Marks
4. What do you mean by competitive antagonism?
5. Explain the JAK-STAT binding receptor transduction mechanism.
6. What are the factors affecting the absorption of drugs?
7. Explain the pharmacology of MAO inhibitors.
8. Explain the organization of the autonomic nervous system.
9. Write the mechanism of action and pharmacology of sodium valproate.
10. Write the pharmacology of gabapentin.
11. Write brief notes on antagonistic drugs of morphine.
12. What is the role of serotonin in central nervous system?
SHORT ANSWERS (Answer All) 10 x 2 = 20 Marks
13. What are the different types of signal transduction mechanism?
14. What do you mean by drug receptor interactions?
15. What is the significance of therapeutic index?
16. What are the combined effects of drugs?
17. Enlist the neurotransmitters in Central Nervous System.
18. How the sympathomimetic agents are classified?
19. What are the adverse reactions of barbiturates?
20. Classify the muscle relaxants with examples.
21. Define the drug tolerance.
22. What are the withdrawal symptoms of anti-depressants?
*****
Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination – 10-Dec-2020
Time: Three Hours Max. Marks: 75 Marks
PHARMACOLOGY - I
Q.P. CODE: 5016
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
1. Describe signal transduction mechanism. Explain in details regulation of receptor and JAK-STAT
binding receptor. (3+3+4)
2. What are Parasympatholytic? Write the classification of Parasympatholytic? Explain
pharmacology of atropine. (1+4+5)
3. Explain neurohumoral transmission in the CNS. Explain the importance of dopamine and GABA.
(4+6)
SHORT ESSAYS (Answer any Seven) 7 x 5 = 35 Marks
4. Explain agonist and antagonist with examples.
5. Short note on ion channel receptors with examples.
6. Explain pharmacology of atenolol.
7. What are classification of neurotransmitters? Explain co-transmission with examples.
8. Explain the principles and mechanism of drug action.
9. Write the classification of general anaesthetics with examples and stages of Anaesthesia.
10. Mechanism of action of phenytoin and its ADR.
11. Define clinical trial. What are the different phases in clinical trials?
12. What are the different nature and source of drugs?
SHORT ANSWERS (Answer All) 10 x 2 = 20 Marks
13. Enlist drugs used in Parkinsons disease.
14. What are drugs used in Alzheimer’s disease.
15. What is myasthenia gravis? Give the drugs used in its treatment.
16. What are the therapeutic uses of sedative and hypnotics?
17. Define tolerance and dependence.
18. Write the classification of anti-anxiety agents.
19. Examples of optional analgesics.
20. What is the significance of pharmacovigilance?
21. Write about methyl alcohol poisoning.
22. Write the uses of sympatholytics.
*****
Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination – 24-Mar-2021
Time: Three Hours Max. Marks: 75 Marks
PHARMACOLOGY - I
Q.P. CODE: 5016
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
All the Questions are compulsory
LONG ESSAYS 2 x 10 = 20 Marks
1. Explain about different routes of drug administration.
OR
Classify general anaesthetic agents and write about the different stages of general anaesthesia.
2. Classify antipsychotic drugs and write the pharmacology of Chlorpromazine
SHORT ESSAYS 7 x 5 = 35 Marks
3. Write about nature and source of drugs with examples.
OR
Write notes on factors modifying effects of the drug.
4. Note on clinical trial phases.
OR
Write in brief about various neurotransmitters in CNS.
5. Enlist drugs used in Myasthenia gravis and glaucoma.
6. Write in brief about anti anxiety agents.
7. Write brief notes on CNS stimulants.
8. Write a note on L-dopa as an anti-parkinsons agents.
9. Write about the pharmacology of Succinylcholine.
SHORT ANSWERS 10 x 2 = 20 Marks
10. What is Essential drug concept?
11. What is drug Tolerance?
12. Classification of receptors.
13. Significance of Therapeutic index.
14. Classification of para-sympathomimetic agents.
15. Drugs used as neuromuscular blocking agents.
16. Adverse effects of barbiturates.
17. Ethosuximide as an anti-epileptic drug.
18. Cocaine as an hallucinogenic agent.
19. Imipramine as an antidepressant drug.
*****
Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination – 23-Nov-2021
Time: Three Hours Max. Marks: 75 Marks
PHARMACOLOGY - I
Q.P. CODE: 5016
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
All the Questions are compulsory
LONG ESSAYS 2 x 10 = 20 Marks
1. Classify drug-drug interactions. Explain in detail the pharmacokinetics drug-drug interaction
with examples.
OR
Classify sedative and hypnotic drugs with examples, write the pharmacology of
benzodiazepines.
2. Classify antidepressant drugs with examples and write the pharmacology of imipramine
SHORT ESSAYS 7 x 5 = 35 Marks
3. Write about agonist, antagonist and different types of antagonism with examples.
OR
Write notes on different routes of drug elimination.
4. Discuss about the mechanism of action of drugs.
OR
Write in brief about adverse reactions of the drugs.
5. Write a note on drugs used in the treatment of Myasthenia gravis.
6. Write in brief about anti epileptic drugs.
7. Write brief notes on opioid antagonistic drugs.
8. Write notes on centrally acting muscle relaxant agents.
9. Explain the pharmacology sympathomimetic agents.
SHORT ANSWERS 10 x 2 = 20 Marks
10. Write notes on spare receptors.
11. Write a brief note on Tachyphylaxis.
12. Importance of the combined effect of the drugs.
13. What is dose response relationship?
14. Classification of parasympatholytic agents.
15. Note on Preanaesthetic agents.
16. Mention about Hallucinogenic agents.
17. Enlist drugs used in Alzheimer disease.
18. Drugs used as Antiparkinsonian agents.
19. Define drug abuse with suitable examples.
*****
Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination – 22-Jun-2022
Time: Three Hours Max. Marks: 75 Marks
PHARMACOLOGY - I
Q.P. CODE: 5016
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
All the Questions are compulsory.
LONG ESSAYS 2 x 10 = 20 Marks
1. What are ion channel receptors? Explain their transduction mechanism.
OR
What are the non-selective beta blockers? Explain the pharmacology of any one non-selective β
blocker.
2. Classify anti epileptics with examples. Explain the pharmacology of phenytoin.
SHORT ESSAYS 7 x 5 = 35 Marks
3. Write about the enzyme induction and inhibition with examples.
OR
Write a note on metabolism of drugs by Phase-I reactions.
4. Explain the pharmacodynamic drug-drug interactions.
OR
What are the different steps involved in drug discovery?
5. Write the pharmacology of dopamine.
6. Write the pharmacology of physostigmine.
7. Explain the pharmacology of any one of the benzodiazepines.
8. Explain the pharmacology of any one of the centrally acting muscle relaxants.
9. Explain about drug tolerance.
SHORT ANSWERS 10 x 2 = 20 Marks
10. Write notes on idiosyncrasy.
11. Define bioavailability.
12. What is the significance of therapeutic index?
13. What is dose response relationship?
14. Classify parasympathomimetic agents.
15. What are the drugs used in glaucoma?
16. Which drugs are used as preanaesthetic agents?
17. What is the mechanism of action of Disulfiram?
18. What is drug addiction?
19. Classify opioid analgesics with examples.
*****
Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination – 24-Nov-2022
Time: Three Hours Max. Marks: 75 Marks
PHARMACOLOGY - I
Q.P. CODE: 5016
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
All the Questions are compulsory.
LONG ESSAYS 2 x 10 = 20 Marks
1. Explain about the signal transduction mechanism of G-protein coupled receptors.
OR
Describe the neurohumoral transmission in adrenergic nervous system.
2. What are the different stages of general anaesthesia?
SHORT ESSAYS 7 x 5 = 35 Marks
3. Explain the Tachyphylaxis with examples.
OR
How the receptors regulate the transcription factors?
4. What are the factors modifying drug action?
OR
Write the pharmacology of Succinylcholine.
5. Write any five functions of the autonomic nervous system.
6. Classify Sympatholytic agents with examples.
7. What is the use of epidural anaesthesia?
8. What is the therapeutic application of Disulfiram?
9. What is the role of GABA in central nervous system?
SHORT ANSWERS 10 x 2 = 20 Marks
10. What are agonists and give examples?
11. Explain the significance of volume of distribution.
12. What is the dose response relationship?
13. What are the applications of pharmacovigilance?
14. Classify anti-epileptic drugs with examples.
15. What are the therapeutic uses of benzodiazepines?
16. What is the therapeutic use of Naloxone?
17. Define drug abuse.
18. What is the role of glycine in central nervous system?
19. Write about the side effects of alcohol.
*****
Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination – 06-Jun-2023
Time: Three Hours Max. Marks: 75 Marks
PHARMACOLOGY - I
Q.P. CODE: 5016
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
All the Questions are compulsory.
LONG ESSAYS 2 x 10 = 20 Marks
1. Enumerate the different mechanisms by which the drugs produce their effect. Write a note on
synergistic effect.
OR
What is epilepsy? Classify antiepileptics with examples. Write the pharmacology of Phenytoin.
2. What are CNS stimulants ? Classify them with example and write the pharmacology of
caffeine.
SHORT ESSAYS 7 x 5 = 35 Marks
3. Explain pharmacovigilance with applications.
OR
Classify Neuromuscular Blocker. Write a note on d-Tuborcurarine.
4. Classify - adrenergic receptor antagonists with examples.
OR
Classify antidepressants, note on imipramine.
5. Biotransformation of drugs.
6. Write the pharmacology of morphine.
7. What do you mean by myasthenia gravis? Explain how cholinergic drugs used in myasthenia
gravis.
8. Write about management of opioid poisoning
9. What measures are taken to overcome alcohol addiction?
SHORT ANSWERS 10 x 2 = 20 Marks
10. Explain drug tolerance.
11. Define volume of distribution.
12. Therapeutic uses of atropine.
13. Define sedative and hypnotics with examples.
14. List out the drugs used in treatment of Alzheimer’s diseases.
15. Enlist the adverse reactions of Lidocaine.
16. Explain the role of glycine in neurotransmission.
17. Name four muscarinic receptor blockers.
18. Define Tachyphylaxis and Idiosyncrasy
19. Define therapeutic index.
*****
Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination – 10-Nov-2023
Time: Three Hours Max. Marks: 75 Marks
PHARMACOLOGY - I
Q.P. CODE: 5016
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
All the Questions are compulsory.
LONG ESSAYS 2 x 10 = 20 Marks
1. Explain the principles and mechanism of drug actions. Explain in detail enzyme linked receptors.
OR
What are sympatholytics? Classify sympatholytics. Explain in detail pharmacology of any one -
receptor blocker.
2. What are sedative and hypnotics. Classify with examples. Add a note on long acting
barbiturates.
SHORT ESSAYS 7 x 5 = 35 Marks
3. What are different routes of drug administration. Explain advantage and disadvantage
of each route of drug administration.
OR
Short notes on drug discovery phases.
4. Explain the adverse drug interactions.
OR
Classify sympathomimetics. Explain the mechanism of action of adrenaline and its uses.
5. Explain the neurohumoral transmission.
6. Explain in detail various pre-anaesthetic medications with examples.
7. Short note on antiepileptic agents.
8. Classify anti Parkinson’s disease agents. Add a note on L-Dopa.
9. What are different nature and source of drugs?
SHORT ANSWERS 10 x 2 = 20 Marks
10. What is Drug tolerance? Give examples.
11. What are spare receptors? Give examples.
12. What is Pharmacodynamics? Enlist the targets for drugs.
13. Write the uses and side effect of D-tubocurarine.
14. Enlist the centrally acting muscle relaxants and write their uses.
15. What is Drug Addiction? Give example of drugs causing Addiction.
16. Enlist drugs used in treatment of myasthenia gravis.
17. What is Pharmacovigilance?
18. Write the classification of local anaesthetics with examples.
19. Enlist drugs used as Anti-depressants.
*****
Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination – 10-Jun-2024
Time: Three Hours Max. Marks: 75 Marks
PHARMACOLOGY - I
Q.P. CODE: 5016
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
All the Questions are compulsory
LONG ESSAYS 2 x 10 = 20 Marks
1. Classify anti-cholinergics with examples. Describe the pharmacological actions of Atropine.
OR
What is Parkinsonism? Classify antiparkinsonian drugs with examples. Write the Pharmacology
of levodopa.
2. Classify drug-drug interaction. Explain in detail the pharmacokinetic drug-drug interactions with
example.
SHORT ESSAYS 7 x 5 = 35 Marks
3. What are different routes of drug administration? Describe transdermal route.
OR
Explain Phase I and Phase II biotransformation with examples.
4. Classify skeletal muscle relaxants. Write a note on D-tubocurarine.
OR
Explain the detail about neurohumoral transmission of Glutamate transmission.
5. Classify drugs use in Alzheimer’s disease and mention their ADR.
6. What are preanaesthetic medications? Explain with examples.
7. Short notes on the different Phases of clinical trials.
8. Classify antiepileptic drugs with examples.
9. Write the pharmacology of naloxone.
SHORT ANSWERS 10 x 2 = 20 Marks
10. Enlist drugs used as anti depressant agents.
11. Define volume of distribution and its importance.
12. Enlist drugs used in Myasthenia gravis.
13. Name the mechanism involved in depression.
14. What is opioid receptor?
15. Define drug abuse and drug dependence
16. Drugs used as nootropics.
17. Define Tachyphylaxis.
18. Explain enzyme induction.
19. Enlist adverse reactions of drugs.
*****
Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination – 04-Nov-2024
Time: Three Hours Max. Marks: 75 Marks
PHARMACOLOGY - I
Q.P. CODE: 5016
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
All the Questions are compulsory.
LONG ESSAYS 2 x 10 = 20 Marks
1. Explain the different membrane transport systems with examples.
OR
What are the different types of drug interactions? Explain the factors affecting the
pharmacodynamic drug-drug-interactions.
2. Write the classification of parasympathomimetics. Explain the pharmacology of acetylcholine.
SHORT ESSAYS 7 x 5 = 35 Marks
3. Explain the significance of volume of distribution.
OR
What do you mean by preclinical toxicity tests? Explain the same.
4. Describe JAK-STAT receptors.
OR
Explain the pharmacology of Catechol-O-Methyl Transferase inhibitors.
5. Write a note on skeletal muscle relaxants.
6. Write the classification of general anaesthetics with examples. Explain the pharmacology of
Ketamine.
7. Explain different neurotransmitters in peripheral nervous system.
8. What is the role of dopamine in central nervous system?
9. Write notes on morphine poisoning.
SHORT ANSWERS 10 x 2 = 20 Marks
10. Write short notes on physiological antagonism
11. Write notes on spare receptors.
12. Write notes on ion channel receptors.
13. Define pharmacovigilance.
14. Write about the functions of Autonomic Nervous System.
15. What are the drugs used in myasthenia gravis?
16. Write the adverse reactions of alcohol.
17. What is the significance of Disulfiram in alcohol addiction?
18. Classify anti-Parkinsonian agents with examples.
19. Classify hallucinogenic agents with examples.
*****
