DR.

BABASAHEB AMBEDKAR TECHNOLOGICAL UNIVERSITY, LONERE

Supplementary Summer Examination – 2024
Course: B. Pharmacy Semester: V
Subject Name: Medicinal Chemistry II Subject Code: BP501T
Max Marks: 75 Date: 13-06-2024 Duration: 3 Hr.
Instructions to the Students:
1. All questions are compulsory
2. Draw diagrams / figures wherever necessary
3. Figures to right indicate full marks
Q.1. Objective Type Questions (Answer All the Questions) (10X2) =20
i) Write mechanism of action and medicinal applications of Ranitidine.
ii) Write synthesis of Warfarin.
iii) Explain gastric proton pump inhibitors.
iv) What is arrhythmia? Classify anti-arrhythmic agents.
v) Give synthetic scheme of Benzocaine.
vi) What are oral contraceptives?
vii) Explain thiazolidinediones as hypoglycemic agents.
viii) Explain stereochemistry of steroids.
ix) Discuss about drugs used for erectile dysfunction.
x) Write a note on corticosteroids.

Q.2. Long Answers (Answer 2 out of 3) (10X2) =20

i) Define Diuretics. Classify diuretics with examples and write mechanism of action and
medicinal applications of drugs belonging to class thiazides.
ii) Classify oral hypoglycemic agents with suitable examples. Comment in detail on sulphonyl
ureas. Draw synthetic route for tolbutamide.
iii) Classify antihistaminic agents with examples and explain in detail H1-antihistaminics and
outline the synthesis of Diphenhydramine hydrochloride.

Q.3. Short Answers (Answer 7 out of 9) (5 X 7) = 35

i) Discuss in detail antihyperlipidemic agents.
ii) Write about coagulant agents.
iii) Discuss about thyroid and anti-thyroid drugs.
iv) What are sex hormones? Classify estrogens with suitable examples.
v) Write a note on cardiac glycosides used in the treatment of CHF.
vi) Classify antianginal agents with suitable examples.
vii) Give classification of anticancer agents with suitable examples and explain alkylating
agents.
viii) Classify local anaesthetics with suitable examples and explain SAR of local anaesthetics.
 ix) Classify antihypertensive drugs and give synthesis of methyldopate hydrochloride.
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 DR. BABASAHEB AMBEDKAR TECHNOLOGICAL UNIVERSITY, LONERE
End Semester Examination – Winter 2022
Date: 22/07/2023
Course : B. Pharmacy Sem: V
Subject Name : Medicinal Chemistry- II Subject Code : BP501T
Max Marks : 75 Duration : 3 Hr.
Instructions:
1. All questions are compulsory
2. Draw diagrams / figures wherever necessary
3. Figures to right indicate full marks
Q. 1. Objective Type Questions (Answer all the questions) (10 x 2) = 20
i) Write mechanism of action of chlorthiazide.
ii) What is arrhythmia? Classify Anti-arrhythmic Drugs.
iii) What are Antihistaminic agents? Classify them.
iv) What are oral contraceptives?
v) How antimetabolites will act as an anticancer agent?
vi) Classify antianginal drugs.
vii) Write synthetic scheme for warfarin.
viii) How Digoxin will help to cure congestive heart failure ?
ix) Write synthetic scheme for tolbutamide.
x) Brief about stereochemistry of steroids.
Q. 2. Long Answers (Answer 2 out of 3) (2 x 10) = 20
i) Explain mechanism of action and SAR of local anesthetic agents. Give
the synthetic route of dibucaine.
ii) Classify the oral hypoglycemic agents with examples and explain
biguanides and thiazolidinediones in details.
iii) What are antihypertensive drugs? Classify them with examples and add a
note on loop diuretics.
Q. 3. Short Answers (Answer 7 out of 9) (7 x 5) = 35
i) Note on Anti-hyperlipidemic agents.
ii) What are steroids? Write a note on corticosteroids.
iii) What is hyperthyroidism. Write a note on antithyroid drugs.
iv) Explain proton pump inhibitors with examples.
v) Explain alkylating agents as antineoplastic drugs.
vi) Write synthesis of diphenhydramine and promethazine.
vii) Classify anti anginal drugs.
viii) Note on calcium channel blockers.
ix) Explain the mechanism of action of vasodilators with examples.

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 DR. BABASAHEB AMBEDKAR TECHNOLOGICAL UNIVERSITY, LONERE
End Semester Examination – Winter 2022
Date: 08/09/2023
Course: B. Pharmacy Sem: V
Subject Name: Medicinal Chemistry-II Subject Code: BP501T
Max Marks: 75 Duration: 3 Hr.
Instructions:
1. All questions are compulsory
2. Draw diagrams / figures wherever necessary
3. Figures to right indicate full marks
Q. 1. Objective Type Questions (Answer all the questions) (10 x 2) = 20

i. Classify antineoplastic agents?

ii. Which nature of second generation antihistamines doesn’t allow penetrating in the
BBB?
iii. What are the different types of diuretics with suitable examples of drugs?
iv. Write the scheme of synthesis of Diphenhydramine hydrochloride?
v. Mention the classification of anti-arrhythmic agents?
vi. Discuss diseases of thyroid gland with suitable example?
vii. Discuss the MOA of alkylating agents?
viii. Write synthesis of Methyldopate hydrochloride?
ix. What is the role of nitric oxide in human body?
x. Write a note on Coagulant & Anticoagulants?
Q. 2. Long Answers (Answer 2 out of 3) (2 x 10) = 20
i. Classify antihistaminic agents by giving examples of each class? Explain in detail H1
antagonists and outline the synthesis of Triprolidine hydrochloride?
ii. What are the MOA and SAR of three drugs used in congestive heart failure, Explain
with chemical structures?
iii. Classify the antihypertensive agents? Discuss in detail about ACE inhibitors and
Angiotensin II Receptor Blocker along with SAR?
Q. 3. Short Answers (Answer 7 out of 9) (7 x 5) = 35

i. Explain and give the chemical reaction in synthesis of Warfarin?

ii. Explain the vasodilators with four examples?
iii. Discuss in detail about testosterone sex hormone with its structure,
metabolism and SAR?
iv. Describe the scheme of synthesis of Chlorthiazide?
v. What is the Mechanism of action and SAR of anti-arrhythmatic drugs with examples?
vi. Explain the term PPIs with examples and diagram?
vii. Explain the Meclorethamine and its synthesis?
viii. Discuss in detail about loop diuretics and thiazide diuretics?
ix. Write a note on Alkylating agents with examples?

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 DR. BABASAHEB AMBEDKAR TECHNOLOGICAL UNIVERSITY, LONERE
End Semester Examination – Winter 2022
Date: 08/02/2023
Course: B. Pharmacy Sem: V
Subject Name: Medicinal Chemistry-II Subject Code: BP501T
Max Marks: 75 Duration: 3 Hr.
Instructions:
1. All questions are compulsory
2. Draw diagrams / figures wherever necessary
3. Figures to right indicate full marks
Q. 1. Objective Type Questions (Answer all the questions) (10 x 2) = 20
i) Define diuretics with suitable examples.
ii) Discuss the MOA of calcium channel blocker.
iii) Classify anti-arrhythmic agents?
iv) Discuss the MOA of Heparin.
v) Draw the structure of Cortisone and Hydrocortisone.
vi) How antimetabolites act as anticancer agents?
vii) Discuss the role of nitric oxide in human body?
viii) Write the scheme of synthesis of Benzocaine.
ix) Explain the diseases of Thyroid gland with suitable example.
x) Write a note on oral contraceptives.
Q. 2. Long Answers (Answer 2 out of 3) (2 x 10) = 20
i) Classify the antihypertensive agents? Discuss in detail about ACE
inhibitors and Angiotensin II Receptor Blocker along with SAR.
ii) Give the classification of Antidiabetic agents with structures from
each class. Discuss the SAR of sulfonylureas and draw the synthesis
of Tolbutamide.
iii) Classify antihistaminic agents by giving examples of each class.
Explain in detail H1 antagonists and outline the synthesis of
Diphenhydramine hydrochloride.
Q. 3. Short Answers (Answer 7 out of 9) (7 x 5) = 35
i) Explain the chemistry and MOA of cardiac glycosides.
ii) Discuss in detail about loop diuretics and thiazide diuretics.
iii) Justify the sentence “Nitro vasodilator act as anti-anginal agent” with
suitable example.
iv) Classify antihyperlipidemic agents with suitable example. Explain
MOA of HMG –CoA Reductase Inhibitors.
v) Classify local anesthetics with suitable example and explain SAR of
local anesthetics.
vi) Discuss in detail about testosterone sex hormone with its structure,
metabolism and SAR.
vii) Classify anticancer agent with suitable examples and explain
Alkylating agents.
viii) Give an account of anticoagulants. Write the synthesis of warfarin.
ix) Discuss proton pump inhibitors along with MOA.

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