[This question paper contains 4 printed pages.

Your Roll No...

Sr. No. of Question Paper :680 G

Unique Paper Code 107693
Name of the Paper Genetics and Genomics II (GGHT
602)
Name of the Course B.Sc. (Hons) Anthropology,
Biochemistry, Biomedical
Sciences, Botaný, Microbiology
and Zoology

Semester VI

Duration : 3 Hours Maximum Marks: 75

Instructions for Candidates:

1. Write your Roll No. on the top immediately on receipt of

this question paper.

Attempt five question in all including Question No. 1 which

is compulsory.

1. (a) Define the following (5)

(i) Target site duplication

(11) Competent cells

(iii) Selection coefficient

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680 3
(iv) Reverse Genetics
(iv) Th. Dobzhansky
iv) Clade
(f Fill in the blank with
appropriate word:
(b) Describe the function of the (3)
following (3) i) The bithorax mutation in Drosophila is an example
1) Transposase of a mutation.

(ii) Resistance transfer factor (ii) Lederberg and Zinder used as an

(iii) F factor organism in the transduction experiment.

(iii) A map based on recombination frequency is called
(c) Distinguish between:
(8) map.
) Local and Global
Sequence Alignment
2. (a) With suitable diagram, describe phage a mediated
(ii) Temperate and Virulent phages
specialized transduction.
(ii) Auxotroph and Prototroph
(b) Explain Hfr. Describe conjugation process between Hfr
(iv) Genomics and Proteomics and F bacteria.
(6+6)
(d) Expand the abbreviations:
(4) 3. (a) With suitable diagrams explain the distinctive features
of various types of
(i) EST prokaryotic transposable elements.
(ii) SINE (b) Describe the role of transposons in genome
organization.
(iii) UTR (9+3)
4. (a) Describe key features of Drosophila
(iv) LTRs.
allow it to be used
melanogaster which
as a model organism.
(e) Write important contributions of the following: (4) (b) Describe the function of homeotic genes in
(i) Davis Bernard animals.
plants and

(ii) Seymour Benzer (c) Write the phenotype of the

following homeotic mutants
of Arabidopsis
(ii) Craig J. Venter
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(i) Loss of B function

(ii) Loss of C function

(iii) Loss of A function

(iv) Complete loss of A, B, and C functions (4+4+4)

5. (a) Differentiate between Bottleneck effect' and 'Founder

effect.

(b) Explain 'Allopatric speciation' with the help of suitable

examples.
(c) The incidence of recessive albinism in a human
population is 0.0004. If mating for this trait is random
in the population, find out the frequency of the recessive
allele and carriers. (4+4+4)

6. (a) Explain and compare 'Structural Genomics' and

Functional Genomics'.

(b) Give a comparative account of distinctive features of

eukaryotic and prokaryotic genome. (6+6)

7. Write short note on any three of the following:

(a) Retrotransposons .'

(b) Human Genome Project

(c) NCBI

(d) Hardy-Weinberg's law (4+4+4)

(1000)