BBCCT-117

ASSIGNMENT BOOKLET

Bachelor (Honours) Degree in BIOCHEMISTRY (BSCBCH)

GENE ORGANISATION, REPLICATION AND REPAIR

School of Sciences
Indira Gandhi National Open University
Maidan Garhi, New Delhi-110068
Dear Student,

Please read the section on assignments in the Programme Guide of B.Sc. (Hons.) Biochemistry
(BSCBCH) that we sent you after your enrolment. A weightage of 30 percent, as you are aware, has
been earmarked for continuous evaluation, which would consist of one tutor-marked assignment for
this course. The assignment is in this booklet, and it consists of two parts, Part A and B. It covers all
blocks of the course. The total marks of all the parts are 100, of which 35% are needed to pass it.

SPECIFIC INSTRUCTIONS FOR TUTOR MARKED ASSIGNMENTS (TMA)

1) Write your Enrolment Number, Name, Full Address, Signature and Date on the top right hand
corner of the first page of your response sheet.

2) Write the Programme Title, Course Code, Course Title, Assignment Code and Name of your
Study Centre on the left hand corner of the first page of your response sheet.

Course Code and Assignment Code may be reproduced from the assignment.

The top of the first page of your response sheet should look like this:

ENROLMENT NO.:

PROGRAMME TITLE : .......................... NAME: ................................................

COURSE CODE : .......................... ADDRESS:.........................................

.............................................................

COURSE TITLE : .......................... .............................................................

ASSIGNMENT CODE : .......................... SIGNATURE:......................................

STUDY CENTRE : .......................... DATE: .................................................

3) Read the assignments carefully and follow the specific instructions, if any, given on the
assignment itself about the subject matter or its presentation.

4) Go through the Units on which the assignments are based (Part A includes Block-1 and 2 and
Part B Block 3 and 4). Make some points regarding the question and then rearrange those points
in a logical order and draw up a rough outline of your answer. While answering an essay type
question, give adequate attention to introduction and conclusion. The introduction must provide a
brief interpretation of the question and how you propose to develop it. The conclusion must
summarise your response to the question. Make sure that the answer is logical and coherent, and
has clear connections between sentences and paragraphs. The answer should be relevant to the
question given in the assignment. Make sure that you have attempted all the main points of the
question. Once you are satisfied with your answer, write down the final version neatly and underline
the points you wish to emphasise. While solving numerical problems, use proper format and give
working notes wherever necessary.

PLEASE FOLLOW THE ABOVE FORMAT STRICTLY TO FACILITATE EVALUATION AND TO

1. Use only foolscap size paper for your response and tie all the pages carefully. Avoid using very
thin paper. Allow a 4 cm margin on the left and at least 4 lines in between each answer. This
would facilitate the evaluator to write useful comments in the margin at appropriate places.
2. Write the responses in your own handwriting. Do not print or type the answers. Do not copy your
answers from the Units/Blocks sent to you by the University. It is advised to write your answers in
your own words as it will help in grasping the study material.
3. Do not copy from the response sheets of other students. If copying is noticed, the assignment will
be rejected.
4. Write each assignment separately. All the assignments should not be written in continuity.
5. Write the question number with each answer.
6. The completed assignment should be submitted to the Coordinator of the Study Centre allotted
to you. TMAs submitted at any other place will not be evaluated.
7. After submitting the TMA, get the acknowledgement from the Coordinator on the prescribed
assignment remittance-cum-acknowledgement card.
8. In case you have requested for a change of Study Centre, you should submit your TMA only to
the original Study Centre until the change of Study Centre is notified by the University.
9. If you find that there is any factual error in evaluation of your assignments e.g. any portion of your
assignment response has not been evaluated or the total of score recorded on your assignment
response is incorrect, you should approach the Coordinator of your study centre for correction
and transmission of correct score to headquarters.

Assignment
 GENE ORGANISATION, REPLICATION AND REPAIR

Course Code: BBCCT-117 Maximum marks:100

Assignment code: BBCCT-117/TMA/2025

Note: Attempt all questions. The marks for each question are indicated against it.
For any question worth 2 marks, the word limit is 50 words, for 5 marks question it is 100 words; and for
10 marks it is 250-300 words.

PART-(A) Maximum marks: 50

1. Describe primary and secondary structure of DNA. 10

2. Compare between prokaryotic and eukaryotic gene. 10

3. Describe the packaging of DNA into higher order structures. 10

4(a) Explain chromosome mapping and banding patterns. 5

(b) Discuss different modes of DNA replication. 5

5. Write a detailed note on topoisomerases. 10

PART-(B) Maximum marks: 50

1. Compare replication in prokaryotes and eukaryotes. 10

2 (a) What are different types of recombination? 5

(b) Differentiate between transposons and retrotransposons. 5

3. What is RNA editing? 10

4. Explain different types of mutations. 10

5(a) Comment on genomic and mitochondrial DNA damage 5

(b) What is xeroderma pigmentosum? 5