GPAT2025__— Section A "Trikatu in Ayurveda is the combination oF ‘Ans 2X A Black pepper, small pepper and ginger C. Black pepper, long pepper and betal 2 B. Black mustard, long pepper and ginger D. Black pepper, long pepper and ginger Q.2 n-Butane exists in how many numbers of conformational isomers: Ans XX ATwoantiandone gauche € C. Two anti and two gauche 8. One anti andtwo gauche KD, One anti and one gauche 0.3 Match the following: IMecanmofeeton aidan YA 2 St [ibis abnosivartoases is torpon —————— Saat é-inhbits mycobacterial ATP-aynthase X 0.1-6,22,3,4d .4 Which of the following diluent is incompatible with primary amines: ‘Ans 3X A.Mannitol 3X B. Microcrystalline Cellulose KX C. Dextrose wD. Lactose Q.5 Rheogram of which system does not start from the origin: ‘Ans A Pseudoplastic systems 2X B. Newtonian systems X C. Dilatant systems yD. Plastic systems .6 Match pair of drug with its family: X B.1-0,2¢3¢,4b Column A Column B me Kw - a) Snake Root i) Compositae SRR lb) Artemisia ii) Rosaceae i) Bitter Almond i) Apocyanaceae CER Beewe ld) Myrrh liv) Burseraceae SRSLY Q.7 Which of the following is used for the evaluation of disinfectants: Ans Wf A.Chick Martin test 9X B. Widal test XC. VDRLtest 2X D. Draves test Q.8 Identify the naturally occurring pilocarpine: Ans XX A.2S,5R(+)pilocarpine € C. 2R4R-(-}pilocarpine X B.3R4S-()pilocarpine D. 35,4R-(+) Q.9 Pyridine is a base with K,, equal to: Ans A.23X109 KB38X107 WKC.32X106 HK 0.1.7x107 Q.10 In supercritical fluid extraction, critical temperature (tc) and critical pressure (pc) for CO, are: locarpine Ans XK A.S1°CandS4atm XB. 51°Cand74atm yf C.31°C and 74aIm J D.31°C and 54.atm 0.11 Which ofthe following is the correctly matched pai: P. True density (i) Reciprocal of bulk density aoe eee Q. Granule density (ii) Graduated cylinder method ere te eee R. Bulk density (ii Helium pyenometer ee S. Bulkiness (iv) Mercury displacement method 0.12 Benzene undergoes Friedel-Crafts reaction with isopropyl bromide inthe presence of anhydrous aluminum chloride catalyst to give: ‘Ans XX A Acetophenone 7 B.Isopropylbenzene XC. Benzophenone XD. nPropylbenzene (0.13 Which among the fllowi methods for tonicity adjustment: ‘Ans A Sodium chorde equivalent method 9X ©. Cryoscopic method 7 8.White Vincent method 2X 0. Molecular concentration method a A(Q.14 Arrange the following alkenes in order of its stability ‘Ans X A. Trans-2-butene > isobutene > cis-2-butene > but-T-ene WB. Isobutene > trans-2-butene > cis-2-butene > but-1-ene XX C. Cis-2-butene > trans-2-butene > but-1-ene > isobutene X D. Trans-2-butene > cis-2-butene > isobutene > but-1-ene Q.15 Alkyl halides are converted into alkanes by: Ans 2 A.Grignardreagent 2X B. Birch reduction 3X C. Sabatier-Sender ef D. Wurtz reaction Q.16 Choose the correct statements regarding Tannins from the following: A) Tannin solution precipitate alkaloids 8B) Hydrolysable tannins produces gall C) Condensed tannins are convert. treatment with acid or enzymes D) Tannins are insoluble in water Ans XK A.OnlyAandD WB. OnlyAB&C RX C.OnlyA XK D.OnlyBaC 0.17 Molecules in the smectic liquid crystals are characterized by which one of the following: Ans 9 A Mobility in two directions and rotation in one axis and ellagic acid by acid or enzyme hydrol to red colored substance known as phlobaphenes on X B. Mobility in tree directions and no rotation X C. Mobility in two directions and no rotation 2X D. Mobility in thee directions and rotation in one axis. .18 Cis-trans (2/E) isomerism is exhibited by all except: Ans XX A 2butene-tol YB. Ibutene PC. 2chloro-thexene AX D. 4chloro-2-pentene 0.19 When the highest dose of a drug is soluble in 250 ml or less of an aqueous medium over the pH range from 1 to 6.8 at 37°C and the extent of absorption in humans is expected to be more than or equal to 85 % of the administered dose, the drug is said to be classified in which of the BCS Class: ans AClass! XX B.Classil 7 C.ClassIV HK D. Classi 0.20 Glycogenic amino acids entered in TCA cycle except: ‘Ans A Glutamate B.Aspartate C.Glycine 0. Alanine .21 Total numberof stereoisomers for 3-bromo-2-butanol is: ae KA6 KB2 KC yds 2.22 What isthe USP prescribed maximum concentration limit for Benzalkonium chloride to be used as preservative in parenteral formulations: Ans PAOOIS KB.005% A C.0001% X 0.005% 0.23 Which is an example of continuous shelf moving bed dryer: ‘Ans A Spray Dryer B. Vacuum Tumble Dyer yf C. Turbo Tay Dryer AKO. Tray Dryer 0.24 Match the folowing with the typeof causative agents: Disease Causative agents Ans X A. Pliv), Q(ili), Rll), S(i) P. Tuberculosis i. Bacteria A B. PAii), Qtii), R(iv), S(i) Q Diphtheria ii. Vir SSinanene R Yellow fever iil, Toxoid 0. Qi), RGD, tiv) . Malaria [iv Protozoa 70.0), A), RG, SC) .25 Which technique is employed for the location of radioactive isotopes in biological and other ‘materials by using X-ray sensitive film: Ans wf A Autoradiography 2 B. Sequential analysis 2 C. Liquid Scintillation Counter X D. Precursor-product sequence OPSection B |-1 Which of the following ids are found as salts of meconic acid: Ans 3X A Ergot alkaloids 9 8. Opium alkaloids 9X C. Rauwolfia alkaloids XD. Tropane alkaloids Q.2 Triple point of water occurs at which temperature and pressure: Ans A.0.0098°C and 4.58 mmHg XB. 0.098°F and 4.58 mmHg X C.0.098°C and 4.58mmHg XD. 0,0098°F and 4.58 mmHg Q.3 Multimeric enzymes which binds substrate in a cooperative fashion analogous to the binding of oxygen in haemoglobin can be best studied by: ‘Ans A.Hansch plot XX B. Craig's plot 2X C. Michaelis-Menten expression 9 D. Hill coefficient Q.4 While performing conductometric titrations for the estimation of acetic acid using 0.1 M sodium hydroxide, after complete neutralization of acetic acid, further addition of titrant causes: Ans «A. Increase in the conductance of the solution C. Colour changes to orange red XX B.No change in conductance of the solution XD. Decrease in conductance of the solution Q.5 Debye is the unit for measuring: Ans 3X A.Bond energy 3 B.Field effect X C. Dissociation constant» D. Dipole moment Q.6 Manufacturing specifications for tooling have been standardized by: Ans 3X A. Physican Desk reference of Industry 2X C. National Drug Code X B. Indian Pharmacopeial Commission _« D. Academy of Pharmaceutical Sciences Q.7 Which of the following is a characteristic of a deflocculated suspension: Ans A Asediment is formed slowly X C. Particles form loose aggregates X B. Suspension is easily redispersable 2X D. A sediment is formed rapidly Q.8 Which of the following indicator is not used in complexometric titrations: Ans XA Xylenol orange X B.Calcon mixture 3X C.Mordant Black II 4 D. Ferroin Q.9 When the log number of microrganisms is plotted against time, an essentially straight line results, The inverse slope of this line is called: Ans Wf A.Dvalue 3 B.Halflife 3 C.Zvalue 7X D. Thermal death time Q.10 Vincristine can be analysed by UV spectrophotometer at Amax: Ans XX A.217nm XK B.245nm JK C.360nm yD. 297nm .11 Minimum manufacturing space required for "Habb-Unani medicine” as per Schedule T of Drugs and Cosmetic Act is Ans XAISOSGFt A B.200SqFt YC. 100SGFt 7% D.s0SqFt 0.12 If the granule density of potassium bicarbonate powder is 2.350 g/cc and true density is 3.560 g/cc, then determine intraparticle porosity: Ans A024 KB056 KC066 0.034 0.13 Choose the correct sentence/s from the following: P) Anthraquinone derivatives are generally detected by Borntrager’s test. Q) Anthrone is pale yellow substance and soluble in alkali. R) Anthranol is insoluble in alkali and shows strong red fluorescence. 'S) Borntrager's test is negative for anthranols (reduced forms). Ans XX A.OnlyP A B.OnlyQandR YC.OnlyPandS 7 D.onyR Q.14 Sedative hypnotic barbiturates are having pk, value in the range of: Ans KA92Z111 XK B.2756 KCA64 Y0.7684 0.15 Amongst the following liquids, which liquid has a highest surface tension against water at 20°C: Ans ZA Mercury XX B.Oleicacid XK C. Carbon Tetrachloride X D. Octane (Q.16 What is the fasting physiological pH value in the jejunum: Ans XK A8.6+04 KK B.32404 KC48+04 Y068t04(0.17 Aryl fluorides ‘obtained from controlled thermal decomposition of dry aryl fluoroborates in the following reaction: ‘Ans € A.Sandmeyer reaction « B.Balz-Schiemann reaction 3X C. Gattermann reaction 3X D. Gomberg reaction 0.18 Which of the following is an exception to Markovnikov's rul ‘Ans € A. Addition of Hito an alkene 2X C. Addition of H0 to an alkene in the presence of acid onium X B. Addition of HCIto an alkene wf D. Addition of HBr to an alkene in the presence of peroxides Q.19 The iron content present in the gelatin for the manufacturing of soft gelatin capsules shell should not exceed: Ans XK ASOPPM XB.20PPM %C.25PPM WD. 15PPM 2.20 Which instrument is used for measurement of structural breakdown in thixotropic material: Ans A Orifice meter XX B. Viscometer_ fC. Planimeter 3X D. Rotameter Q.21 Ring juncture or backbone carbons in Sa-cholestane molecule are: Ans A.589,10,13 and 15 2 B.5,6.9,10,13 and 14 KC. 58.9,10,11 and 14 wD. 58,9,10,13 and 14 0.22 Morphine shows absorbance of Ultraviolet light at wavelengt! Ans A.266nm J B.256nm WC.286nm J D.276nm (0.23 What s the purpose of knowing the value o ‘inthe likovic equation ‘Ans of A To calculate the mass flow rate of mercury 9X C. To calculate mass of electrons transferred X B. To determine the mass of analyte 2D. To determine the drop time .24 The particle size range that can be analysed by Optical Microscopy method is: Ans XK A.0.007-0.1 ym KB. 200-500 jum IX C. 500-1000 pm wf D. 0.5-150 pm .25 Stationary phase used in steroid separation by paper chromatography is: Ans A. Acetylated paper B.Kieselguhr paper C. Carboxyl paper _D. Silica paper Section GC Q.1 Which of the following statement(s) is/are correct regarding Salt bridge used in potentiometric titrations: |. Prevents possible contamination of the reference electrodes with the test solutions Il, Not designed as part of reference electrode Ill. Has no effect on liquid junction potential IV. Mostly solidified with 3% agar Ans KAMER XBlony WCE XK DIeMll Q.2 Albinism is due to complete or partial absence of the following enzyme: Ans V/A. Tyrosinase 2X B.Pyurvase XX C.Bhydroxylase KD. Hydroxylase Q.3 BPaLM regimen is a combination of following drugs: ‘Ans X A Bedaquiline, Pyrazinamide, Linezolid and Moxifloxacin X B. Bedaquiline, Pyrazinamide, Levofloxacin and Moxifloxacin X C. Bedaquiline, Pretomanid, Linezolid and Montelukast # D. Bedaquiline, Pretomanid, Linezolid and Moxifloxacin Q.4 Oral vaccines such as Dukoral® and Shanchol™, provide protection against: Ans XX A.Pneumonia 3X B.Ebola virus 7 C.Polio yD. Cholera Q.5 The number of carbon present in Pregnane is: ans KA27 KBI9 Kw wd21 Q.6 Which of the following is not a part of the Karl Fischer reagent: Ans 3X A lodine 8. Pyrimidine 3X C. Pyridine 3X D. Sulfur dioxide Q.7 Arrange the following steps in the correct order as they occur in the drug discovery process: 1. Lead Optimisation 2. Target Selection 3. Lead Finding Ans KA1>2>3 KB3>1>2 YC.2>3>1 KV.251>3 aESS 'Q.8 Match the following: Class Drug 1. Alkylating agent a. Mechlorethar 2. Platinum analog b. Cisplatin 3. Antimetabolite c. 5-Fluorouracil 4. Growth factor receptor inhibitor d. Cetuximab Ans XK A.1b,24,3d,4¢ YB.1-0,2b,304d 9 C.1-b,20,3¢,4d J D.1-a,2-b,3d,4¢ Q.9 In A/B trans ring junction of steroid, hydrogen atom at 5" position has: ‘Ans 3X A Beta configuration 9X B. Gauche conformation # C.Alpha configuration XD. Eclipsed conformation (2.10 Fora drug if the label or the contain bears he name ofan individual or company purporting tobe the manutactre ofthe arog where the ndvidul or company i ettaus of doce not tiie, sucha drag ale ‘Ans 4 A Spurious drug 9X B. Misbranded drug 9X C. Mixed drug 3 D. Adulterated drug Q.11 Match the following Ans KAAPBOCS&DR Ppisexcies [utepeiototoums [pisaesien —_lOpsenwistrsuocaaesang————~di:C(ié‘ét BAB GLCREDS VC ARBSCORDP [pisceaiee ———[Bstotrescistenanes ] KX DARBS.CPADA 0.12 which parasic worm Te responsible for causing hrnphati i ‘Ans 3X A Necator americanus 3X B. Ancylostoma duodenale 3X C. Onchocerca volvulus WD. Brugia malayi Q.13 Methotrexate is the classic antimetabolite of folic acid structurally derived by N-methylation of the para-aminobenzoic residue (PABA) and replacement of a pteridine hydroxyl by the intone Bsaomer Ans ACF XXBSH WCNH, 2 D.CHy ate Mach he folowing Class Antiarrhythmic drugs 1. Class [a. Disopyramide 2. Class-I lb. Metoprolol 3. Class-il fc. Amiodarone - °0.1-2,2, 3-6, 4d [4. Class-IV |a. Verapamil Q.15 Which of the following drugs when given with warfarin induces hepatic P450 enzymes: Ans XK A Metronidazole « 8. Carbamazepine 3X C. Amiodarone XD. Ciprofloxacin .16 What score range is categorized as Probable’ in the Naranjo Causality Assessment Scale for adverse drug reactions (ADR): ans KAI-4 KBs0 KC29 wos-s 0.17 Furosemide inhibits: ‘Ans A The Na*/Ct co-transporter in the distal convoluted tubule «WB. The Na*/K*/2Cr co-ransporter in the ascending loop of Henle X C. The Na* channel controlled by aldosterone's protein mediator XX D. The Na*/K* co-transporter in the distal nephron and collecting tubules .18 Which one of the following antiplatelet drug acts by P2V12 receptor antagonism: Ans fA Clopidogrel XX B. Aspirin XX C.Tirofiban 3K D. Dipyridamol Q.19 Mirabegron is primarily used in the treatment of overactive bladder. It is well known a: ‘Ans «A. B3-selective adrenergic receptor agonist XC, B2-selective adrenergic receptor agonist 2 B. Selective M3 receptor antagonist 2X D.Non-selective a-blocker —lect the proper si rom start of contraction regarding skeletal muscle contraction: ‘A. Release of calcium from sarcoplasmic reticulum after change in potential B. Stimulation of motor end plate with acetylcholine C. Troponin binds with calcium causing expose of binding sites for myosin D. Actin and myosin crossbridge leads to power stroke ans AKAABCD WBBACD C.BCDA XD. BCAD Q.21 Which of the following is a peroxisome proliferator-activated receptor gamma agonist: Ans 2X A.Metformin X B.Acarbose 3 C. Sulphonylureas «0. Pioglitazone .22 Match the following: Ane) ICAASREES Pancreatic islet cells type Secretory Product —— 1. Alpha (a) cell a. Glucagon XK B.14,2b,30,4d 2: Beta (8) cell b. Somatostatin : 3. Delta (6) cell c. Gastrin Soieeeeee 4.G cell d. Proinsulin 7°0.1.424,3,40 0.23 The cyanide ions can be determined by Nephelo-Turbidimetry as salt of cyanide with: Ans A Sodium (Na) % B. Potassium (kK) yC.Sllver(As) XD. Gold (Au) Q.24 A structural hybrid of Meperidine and Methadone is: ‘Ans A.Diphenoxylate B.Lofentanil —C. Pentazocine _D. Loperamide Q.25 Which of the following will be most easily diazotised: Ans XK A.P-Bromo aniline 3X B. P-Nitro aniline X C.P-Choloroaniline D. Aniline nt Section D ————— ‘Q.1 How much sodium hydroxide is required to prepare 200 ml of 0.15 M solution: Ans XK A189ram HK B.1.5gram HK C.1.0 9M 0.12 orm Q.2 The flow in which viscosity increases wnen tne Substanée 1s sheared Is known as: ‘Ans 3X A.Pseudoplastic flow 8. Dilatant flow 9X C. Newtonian flow > D. Plastic flow Q.3 Which statistical test is appropriate for comparing the means of two independent groups: Ans XX A.ANOVA XX B.Pairedt-Test C.SampletTest WD. Pooled t-Test Q.4 Which of the following masking agents is used to mask the Iron (II) ion during the complexometric titration: Ans A Potassium cyanide 3X B. Triethanolamine XX C. Thioglycerol JX D. Ammonium fluoride Q.5 The recombination of the fragments can be avoided by maintaining which of the following systems that decreases the number of collisions between fragments or molecules: ‘Ans A. Low Temperature B.High Pressure C. Low Pressure _D. High Temperature Q.6 Which one of the following is an antidote for organophosphorous poisoning: Ans A Pralidoxime JX B. Physostigmine 3X C. Sodium thiosulphate 3 D. Naloxone Q.7 Match the following schedule with their correct description: Schedules Descriptions (I) Schedule FF (P) Standard for sterilized umbilical tapes (ll) Schedule F3 (Q) Requirements and guidelines on clinical trials for import and manufacture of new drug (ill) Schedule V (R) Standard for ophthalmic preparations (IV) Schedule Y (S) Standard for patent or proprietary medicines Ans XK AFPIFR IIS IV-Q KC. ER, I+, IIE, IV-S. A B.ERIFPIS,IV-Q 3K D. FP.ILQ,IIFR,IV-S Q.8 The below mentioned equation is known as: ‘Ans A Clausius-Mossott equation P2 __ AHV(T2=T1) v8 ose cepevoneauaion | xX c totamann ack equation PL 2.303 RT1T2 2 D.BET equ os Merronjudy, 50% of women diagnosed with venous thrombosis were found to be using oral contraceptives compared to a group without thrombosis. What type of study design is represented: Ans A Cross-sectional study 8. Case control study XK C, Randomised controlled study 2X . Cohort study .10 How much volume of raw spirit can an excise officer withdraw as sample: ‘Ans 3X A Maximum three samples from a batch each not more than 100 mL. B. Maximum two samples from a batch each not more than 100 mL. X C. Maximum three samples from a batch each not more than 150 mL. «7 D. Maximum two samples from a batch each not more than 150 mL Q.11 As per ICH guidelines, the temperature and humidity conditions of climatic zone-II respectively are: Ans Gf A.25°C,60%RH 2X B.21°C,45%RH XX C.30°C,35%RH HX D.30°C, 65% RH Q.12 According to Baeyer Strain Theory, which of the following cycloalkanes is most stable: Ans WA Cyclopentane JX B.Cyclopropane XX C.Cyclooctane 3X D. Cyclobutane Q.13 Which of following test is distribution free, .e., does not require any assumption to be made about population following normal or any other distribution: ‘Ans XX A Fischer LSD test XX B.Studentttest 7 C. Kruskal Wallis test 3X D. ANOVA .14 What is the effect of co-administering diltiazem with cyclosporin: ‘Ans A Increased nephrotoxicity of ditiazem 3X C. Decreased blood levels of cyclosporin «7 8. Increased blood levels of cyclosporin 9X D. No interaction between the two drugs Q.15 Which one of the following anticonvulsant drugs act on a selective molecular target: Ans Vf A Tiagabine ‘Q.16 What is the blood concentration ratio of Trimethoprim and Sulfamethoxazole after their administration in the ratio of 1:5: Ans A110 KB KC D120 Q.17 The Kozeny - Carman equation is related to: Ans Wf A Permeability to particle size and bed porosity X 8B. Pressure drop in turbulent flow X C. Heat transfer coefficient X D. Sedimentation velocity .18 According to USP, sparingly soluble refers to how many parts of solvent is required to dissolve one part of the solute: Ans Wf A From 30 to 100 X C. From 100 to 1000 XK B.From 1000to0 10000 D. From 10 to 30 Q.19 Walden inversion is associated with: Ans 3X A Both Sy1 and Sy2 reactions 3X B. Elimination reaction WA C. Sy2 reaction X D.Sy1 reaction Q.20 An antibiotic has an elimination half life of 3 to 6 hours in the general population. A patient was given an IV infusion of an antibiotic at an infusion rate of 15 mg/h. Blood samples were taken at 8 and 24 hours, and plasma drug concentrations were 5.5 and 6.5 mg/L, respectively. Estimate the elimination half - life of the drug in this patient: Ans X A.4.96hours XK B.1.58hours JX C.3.58hours WD. 2.96 hours Q.21 Nitrodisc is an example of which type of drug delivery system: Ans 2X A. Ocular Wf 8. Transdermal KC. Mucos: xo.2.22 Which equation is used for explaining the theory of filtration: Ans 3X A Stoke's equation XK C. Dalton’s equation XX B. BET equation @ D. Darcy's equation Q.23 The indicator involved in Fajans method is: ‘Ans 3X A Phenolphthalein 9 8. Dichlorofluorescein 9X C. Methylred XD. Xylene orange Q.24 Vigabatrin is an inhibitor of Ans «fA GABA transaminase XX C. GABA synthase 2X B. Chloride ion channels XX D. Voltage gated Na* channel Q.25 What type of reaction is the Diels-Alder reaction: Ans Wf A Cycloaddition X C. Electrophilic substitution % B. Nucleophilic addition X D. Elimination Ce ooo Section E Q.1. Which of the following anticancer medications causes Hand - Foot syndrome: Ans XX A. Doxorubicin 3X B. Vincristine w C.Capecitabine x D. Methotrexate Q.2 Which broad spectrum antimicrobial agent is commonly used tor preservation ot pharmaceutical formulations: Ans 3X A.VitaminC # B. Benzalkonium chloride 9X C. Sorbic acid KX D. Benzoic acid Q.3 Antiviral drugs used for the treatment of influenza act by inhibiting the enzyme: Ans Wf A. Neuraminidase 2K B. DNA polymerase X C. Reverse transcriptase 2X D. Protease Q.4 Which of the following pair is correctly matched in terms of laxative type and its mechanism of action: Ans A Prucalopride: SHT, agonist 9K C. Lubiprostone : Faecal softener XX B. Lactulose : Stimulant laxative 9X D. Senna : Bulk forming laxative Q.5 Which nasal decongestant is a selective a-2 adrenergic receptor agonist: Ans «A. Oxymetazoline JX B.Loratadine XX C. Montelukast 3X D. Cetirizine Q.6 The common name of convective transport is: Ans XK A. Endocytosis XX B. Passive transport XX C. Active transport « D. Pore transport Q.7 Atype IV PDE inhibitor used for the treatment of COPD is: Ans XX A.Montelukast 2X B.Cromoglicate «f C.Roflumilast 3X D. Reslizumab Q.8 Manucol is also known as: Ans X A.Carbopol XX B.Alginicacid XX C.Guargum — D. Sodium alginate Q.9 Which electrolyte imbalance is commonly associated with Amphotericin B: Ans 3X A. Hypercalcemia X B. Hyponatremia }¢ C. Hypermagnesemia Wf D. Hypokalemia Q.10 Which of the following causes shift in the oxygen-hemoglobin dissociation curve to the right: ‘Ans X A Decreased PCO? X B. increased PO, X C. Decreased H* concentration @ D. increased PCO2 aQ.11 Thixotropic behaviour is associated with: Ans Wf A.Sol-gel-sol transformation XB, Solid and liquid behaviour X C. Increase in viscosity X D. Decrease in viscosity Q.12 Which one of the following is used in the treatment of bronchial asthma and belongs to beta- 2 sympathomimetics: ‘Ans 3 A.Ketotifen XB. Ipratropium bromide wf C.Salmeterol XD. Theophylline Q.13 Energy of activation (Ea) of thermal decomposition of glucose by first order reaction can be calculated from: Ans 3X A. The Y-axis intercept of Arrhenius plot X C. The X-axis intercept of Arrhenius plot 2X B. From rate constant at room temperature 7 0. The slope of Arrhenius plot Q.14 Which one of the following anemias is characterized by microcytic, hypochromic red blood cells: Ans A.Pemicious anemia XX B. Aplastic anemia «VC. Iron deficiency anemia 3X D. Hemolytic anemia .15 Zeta potential of aqueous suspension can be determined by measuring: ‘Ans Wf A Electrophoretic mobility of particles YX C. Dielectric constant 2 B. Charges on particles X D. Density Q.16 In slow IV infusion, what is the time to reach 99% of the steady state concentration: Ans 2 A.3.32halflives XX B.232halflives 7 C.4.32halflives wD. 6.65 half lives Q.17 ISO standard presenting the model for quality assurance in design, development, production, installation and servicing is: Ans 2X A.1S09002 7 B.1S09000 % C.1S09004 yw. 1S0 9001 Q.18 The sedimentation volume of pharmaceutical suspension is: ‘Ans 9 A Ultimate height of sediment / initial height of total suspension X B. Initial height of total suspension / Ultimate height of sediment X C. Volume of sediment X D. Volume of flocculated suspension 0.19 A powder has Carr's compressibility Index value in the range of 12-16. The flowability of the powder is: Ans KAPoor KB.Fair —C.Good XD. Excellent Q.20 Which of the following is a characteristic of HIV infection: Ans 4 A. Depletion of CD4* T cells, X C. Increased natural killer cell activity X B. increased CD8* T cells X D. Increased B cell function .21 After which phase of clinical trial, can a pharmaceutical company submit new drug application (NDA) to the licensing authority: ‘Ans fA Phase lll XX B.PhaselV XX C.Phasell 3X D. Phase! Q.22 Alll of the following are long acting GnRH agonists EXCEPT: ‘Ans A. Triptorelin B. Cabergoline C. Ganirelix D. Buserelin 0.23 Bempedoic acid, a dicarboxylic acid, is a new class of cholesterol-lowering drug that act by 9: ‘Ans 3X A. Proprotein Convertase Subtilism / Kexin type 9. 9X C. Apolipoprotein B-100 synthesis JH B. ATP-citrate lyase XD. Microsomal Triglyceride transfer protein Q.24 Bambuterol is a prodrug of: Ans A Terbutaline XX B. Indacaterol XX C. Salmeterol XX D. Albuterol Q.25 SHT 2A/2C inhibitor used to treat migraine is: Ans XX A.Metoclopramide 3X B. Ketanserin WC. Methysergide 9K D. Renzapride OO