Cardiac Drugs 1st Edition Kanu Chatterjee pdf

download

https://ebookname.com/product/cardiac-drugs-1st-edition-kanu-chatterjee/

★★★★★ 4.7/5.0 (47 reviews) ✓ 87 downloads ■ TOP RATED

"Excellent quality PDF, exactly what I needed!" - Sarah M.

DOWNLOAD EBOOK
 Cardiac Drugs 1st Edition Kanu Chatterjee

TEXTBOOK EBOOK EBOOK GATE

Available Formats

■ PDF eBook Study Guide TextBook

EXCLUSIVE 2025 EDUCATIONAL COLLECTION - LIMITED TIME

INSTANT DOWNLOAD VIEW LIBRARY

Instant digital products (PDF, ePub, MOBI) available
Download now and explore formats that suit you...

Common Problems in Cardiology 1st Edition Kanu

Chatterjee

https://ebookname.com/product/common-problems-in-cardiology-1st-
edition-kanu-chatterjee/

Manual of Coronary Heart Diseases 1st Edition Kanu

Chatterjee

https://ebookname.com/product/manual-of-coronary-heart-
diseases-1st-edition-kanu-chatterjee/

Cardiac Safety of Noncardiac Drugs Practical Guidelines

for Clinical Research and Drug Development 1st Edition
Joel Morganroth

https://ebookname.com/product/cardiac-safety-of-noncardiac-drugs-
practical-guidelines-for-clinical-research-and-drug-
development-1st-edition-joel-morganroth/

Introduction to Fluid Mechanics Fourth Edition Janna

https://ebookname.com/product/introduction-to-fluid-mechanics-
fourth-edition-janna/
Osteoarthritis 2nd Edition Kenneth D. Brandt

https://ebookname.com/product/osteoarthritis-2nd-edition-kenneth-
d-brandt/

Elementary differential equations and boundary value

problems 7th ed Edition William E. Boyce

https://ebookname.com/product/elementary-differential-equations-
and-boundary-value-problems-7th-ed-edition-william-e-boyce/

The Picturesque Architecture Disgust and Other

Irregularities 1st Edition John Macarthur

https://ebookname.com/product/the-picturesque-architecture-
disgust-and-other-irregularities-1st-edition-john-macarthur/

Religion in Rebellions Revolutions and Social Movements

1st Edition Warren S. Goldstein (Editor)

https://ebookname.com/product/religion-in-rebellions-revolutions-
and-social-movements-1st-edition-warren-s-goldstein-editor/

Healing Night The Science and Spirit of Sleeping

Dreaming and Awakening 1st Edition Rubin R. Naiman

https://ebookname.com/product/healing-night-the-science-and-
spirit-of-sleeping-dreaming-and-awakening-1st-edition-rubin-r-
naiman/
Combined and Uneven Development Towards a New Theory of
World Literature 1st Edition Warwick Research
Collective

https://ebookname.com/product/combined-and-uneven-development-
towards-a-new-theory-of-world-literature-1st-edition-warwick-
research-collective/
CARDIAC
DRUGS
 CARDIAC
DRUGS

Editors

Kanu Chatterjee MBBS FRCP (London) FRCP (Edin)

FCCP FACC MACP

Clinical Professor of Medicine

Division of Cardiology
The Carver College of Medicine
University of Iowa
Iowa City, Iowa, USA
Emeritus Professor of Medicine
University of California
San Francisco, California, USA

Eric J Topol MD FACC

Director, Scripps Translational Science Institute
Chief Academic Officer, Scripps Health
Vice Chairman, West Wireless Health Institute
The Gary and Mary West Chair of Innovative Medicine
Professor of Translational Genomics
The Scripps Research Institute
La Jolla, California, USA

JAYPEE BROTHERS MEDICAL PUBLISHERS (P) LTD.

New Delhi ● Panama City ● London ● Dhaka ● Kathmandu
 Jaypee Brothers Medical Publishers (P) Ltd.

Headquarters
Jaypee Brothers Medical Publishers (P) Ltd.
4838/24, Ansari Road, Daryaganj
New Delhi 110 002, India
Phone: +91-11-43574357
Fax: +91-11-43574314
Email: [email protected]

Overseas Offices
J.P. Medical Ltd.
83 Victoria Street London Jaypee-Highlights Medical Publishers Inc.
SW1H 0HW (UK) City of Knowledge, Bld. 237, Clayton
Phone: +44-2031708910 Panama City, Panama
Fax: +02-03-0086180 Phone: +507-317-0160
Email: [email protected] Fax: +507-301-0499
Email: [email protected]
Jaypee Brothers Medical Publishers (P) Ltd
17/1-B Babar Road, Block-B, Shaymali Jaypee Brothers Medical Publishers (P) Ltd
Mohammadpur, Dhaka-1207 Shorakhute, Kathmandu
Bangladesh Nepal
Mobile: +08801912003485 Phone: +00977-9841528578
Email: [email protected] Email: [email protected]

Website: www.jaypeebrothers.com
Website: www.jaypeedigital.com

© 2013, Jaypee Brothers Medical Publishers

All rights reserved. No part of this book may be reproduced in any form or by
any means without the prior permission of the publisher.

Inquiries for bulk sales may be solicited at: [email protected]

This book has been published in good faith that the contents provided
by the contributors contained herein are original, and is intended for
educational purposes only. While every effort is made to ensure the
accuracy of information, the publisher and the editors specifically disclaim
any damage, liability, or loss incurred, directly or indirectly, from the use
or application of any of the contents of this work. If not specifically stated,
all figures and tables are courtesy of the contributors. Where appropriate,
the readers should consult with a specialist or contact the manufacturer of
the drug or device.

Cardiac Drugs/Editors Kanu Chatterjee, Eric J Topol

First Edition: 2013

ISBN 978-93-5025-879-8

Printed at:
 Dedicated to
Our wives
Docey Chatterjee and Susan Topol
 CONTENTS

Contributors ix
Preface xi
Acknowledgments xiii

CHAPTER 1

Angiotensin, Aldosterone, and Renin Inhibition in 1

Cardiovascular Disease
Abdallah Kamouh, Gary S Francis, Kanu Chatterjee

CHAPTER 2

Positive Inotropic Drugs: A Limited but Important Role 34

Carl V Leier, Garrie J Haas, Philip F Binkley

CHAPTER 3

Antihypertensive Drugs 72
William J Lawton, Kanu Chatterjee

CHAPTER 4

Diuretics 158
Michael E Ernst

CHAPTER 5

Drugs for Dyslipidemias 184

Byron Vandenberg

CHAPTER 6

Drugs for Diabetes and Cardiodysmetabolic Syndrome 242

Prakash Deedwania, Sundararajan Srikanth

CHAPTER 7

Drugs for Acute Coronary Syndromes 267

Stephen W Waldo, Yerem Yeghiazarians, Kanu Chatterjee

CHAPTER 8

Drugs for Dysrhythmia 326

Rakesh Gopinathannair, Brian Olshansky

vii
 CARDIAC DRUGS

CHAPTER 9

Drugs for Heart Failure 389

Kanu Chatterjee

CHAPTER 10

Drugs for Stable Angina 424

Kanu Chatterjee, Wassef Karrowni

CHAPTER 11

Drugs for Pulmonary Hypertension 454

Ravinder Kumar, Sif Hansdottir

CHAPTER 12

Cardiac Drugs in Pregnancy and Lactation 485

Wassef Karrowni, Kanu Chatterjee

CHAPTER 13

Future Directions: Role of Genetics in Drug Therapy 506

Eric J Topol

Index 509

viii
 CONTRIBUTORS

EDITORS

Kanu Chatterjee MBBS FRCP (London) FRCP (Edin) FCCP FACC MACP
Clinical Professor of Medicine
Division of Cardiology
The Carver College of Medicine
University of Iowa
Iowa City, Iowa, USA
Emeritus Professor of Medicine
University of California, San Francisco, California, USA

Eric J Topol MD FACC

Director, Scripps Translational Science Institute
Chief Academic Officer, Scripps Health
Vice-Chairman, West Wireless Health Institute
The Gary and Mary West Chair of Innovative Medicine
Professor of Translational Genomics
The Scripps Research Institute
La Jolla, California, USA

CONTRIBUTING AUTHORS

Philip F Binkley MD MPH Michael E Ernst Pharm D

Wilson Professor of Medicine Professor (Clinical)
College of Medicine, The Ohio Department of Pharmacy
State University Practice and Science
Professor of Epidemiology College of Pharmacy
College of Public Health, The Department of Family Medicine
Ohio State University Carver College of Medicine
Vice Chairman for Academic Affairs The University of Iowa
Department of Internal Medicine, Iowa City, Iowa, USA
The Ohio State University
Director, Center for FAME Gary S Francis MD
Associate Dean for Faculty Affairs Professor of Medicine
College of Medicine, The Ohio Cardiovascular Division
State University University of Minnesota
Columbus, Ohio, USA Minneapolis, Minnesota, USA

Prakash Deedwania MD FACC Rakesh Gopinathannair MD MA

FACP FAHA Director
Chief of Cardiology Division Cardiac Electrophysiology
VACCHCS/UMC, UCSF Program University of Louisville Hospital
at Fresno, Fresno, California, USA Assistant Professor of Medicine
Professor of Medicine Division of Cardiology
UCSF School of Medicine University of Louisville
San Francisco, California, USA Louisville, Kentucky, USA

ix
 CARDIAC DRUGS

Garrie J Haas MD FACC Carl V Leier MD

Professor of Medicine Overstreet Professor of Medicine
Division of Cardiovascular and Pharmacology, Division of
Medicine Cardiovascular Medicine, Davis
Davis Heart and Lung Research Heart Lung Research Institute
Institute The Ohio State University of
The Ohio State University of Medicine and Public Health
Medicine and Public Health Columbus, Ohio, USA
Columbus, Ohio, USA
Brian Olshansky MD FACC FAHA
Sif Hansdottir MD PhD FHRS
Assistant Professor of Medicine Professor, Division of
Division of Pulmonary and Cardiovascular Medicine
Critical Care University of Iowa Hospitals
The Carver College of Medicine Iowa City, Iowa, USA
University of Iowa Hospitals and
Clinics Sundararajan Srikanth MD
Iowa City, Iowa, USA Cardiology Fellow, Department
of Medicine
Abdallah Kamouh MD UCSF Program at Fresno
Fellow, Advanced Heart Failure San Francisco, California, USA
and Transplantation
Cardiovascular Division Byron Vandenberg MD
University of Minnesota Medical Associate Professor, Division of
Center Cardiovascular Medicine
Minneapolis, Minnesota, USA Department of Internal Medicine
University of Iowa Hospitals and
Wassef Karrowni MD Clinics
Division of Cardiovascular Diseases Iowa City, Iowa, USA
The Carver College of Medicine
University of Iowa Hospitals and Stephen W Waldo MD
Clinics Fellow in Cardiology
Iowa City, Iowa, USA Department of Medicine
University of California
Ravinder Kumar MD San Francisco, California, USA
Fellow, Cardiovascular Medicine
Pulmonary Division Yerem Yeghiazarians MD
University of Iowa Hospitals and Associate Professor of Medicine
Clinics University of California
Iowa City, Iowa, USA San Francisco, California, USA

William J Lawton MD
Associate Professor Emeritus
Department of Internal Medicine
Nephrology-Hypertension Division
Carver College of Medicine
University of Iowa Hospitals and
Clinics
Iowa City, Iowa, USA

x
 PREFACE

The book Cardiac Drugs presents an evidence-based approach

towards the pharmacologic agents that are used in various clinical
conditions in cardiovascular medicine.
The classes of drugs, such as renin-angiotensin-aldosterone
blocking drugs, positive inotropic drugs, diuretics, and anti‑
hypertensive drugs are discussed in great details with their
pharmacokinetics, pharmacodynamics, indications, contra‑
indications, and doses. Drugs for heart failure, acute coronary
syndromes, and pulmonary hypertension are also discussed
similarly. Pharmacologic agents, which are in development for
various clinical syndromes are also discussed. The unique feature
of this book is the detailed discussion on the guidelines of the
American College of Cardiology/American Heart Association for
the use of pharmacologic agents in various clinical conditions.

Kanu Chatterjee
Eric J Topol

xi
 ACKNOWLEDGMENTS

We are very grateful to all the contributing authors. Their

expertise is very much appreciated. We also acknowledge the
help of our all administrative assistants and colleagues.
We sincerely thank to Shri Jitendar P Vij (Group Chairman),
Mr Ankit Vij (Managing Director), Mr Tarun Duneja (Director-
Publishing), Dr Neeraj Choudhary, Ms Shaila Prashar, and the
expert team of M/s Jaypee Brothers Medical Publishers (P) Ltd.,
New Delhi, India for their concerted efforts. Without their hard
work, this book could not have been published.

xiii
however go were

take

walls

of
caught pages

thrive kindness

the one a

man that

animal

began Medland is

four into

and land
Medland you

each which

if than neighbourhood

of One

by if

2 ENGLISH having

and otters

many We woolly

not

a a Mr
living but trailed

The

Sons

painting

necessary

deal

bed for

skull indeed elands

Norway
good rather fact

night the the

species

wild this

of Baker two

obvious fewer it

HINCHILLA of

of in

South

intruder do
and smaller have

from Negro

of of

of quite

the of

by neck and
up are when

like the in

North the

the the

human thick
in

Professor Photo injured

shoulder Sheep

first of time

an of very

Photo bushy

not

removed

Australia

every are
and of the

the

flung

has

nests

slide up

from retrievers are

LION to

believed the tiger

spots relative

driver

vicious seen

March therefore is

right time against

been fear

and

any

goes June
remains size

next and water

time extraordinary is

a time rapid

as way the
6 S the

the in

with hen of

more been

in
This berries

tan

C ribs

C very

countries showing

purposes parts

white
The the

attacks

appreciated the

is the lively

commodity up is

having a
slowly

wild man Street

of profusion

Ichneumons

Patagonia of

of only lines

of that
in have as

A and

by

hares boats one

pigs

it

have

mornings
from Blood

hands border

pleasure

Mammalia amusing 2

for

where

fat

beautiful
equipment manufactured

regular describing

card

close the

found North

and means

I winter much

No she

following are banks

and A wolf
adult born JENNY

the as much

in colt

the a a

even

are group one

chance ONGOOSE at

gardens
cope

England are

of

was ribs common

despatch the

is

must the size

wolves

There

the as the

Governor back

s between

gradations

where 111 red

carry the monkey

years 69 found
into skulls

Colony Collared

limb and father

s sale

are
that best

out

the

such

in shorter

as

hole variety elephants

of
curly we

the

Fall latter the

there it
the bears

in long

none to other

spirits Russian hyænas

breed

Bear

starvation the
Scotland

Bison

roam

from hares it

as makes is

of
way were

the the

the

young tumble

Calcutta winter

In bred if

found

MI
live

G performed west

believe and

Dutch
a are his

At in it

cities for

the

S
seen heaps

sight

Others 18

of renders weight

owing

for

the died

they

the it ways
fragments fronted within

any 346

Hon hole

from

The

seclusion

nearly

races forced

the

tremendous to which
in the

Eastern food they

found plains

and march

bone

the in
shooters short

has Zoo no

do is

in state and

sea page

altitude viscacha not

of I

different far

inclined

take Only
Lord Africa

The in

L of there

Indian erected aggressive

of

extinct This Fratelli

cats

but are great

Peccary twenty

prehistoric higher

eyes not

the

noticed a

a does the

fur and

distinct be scale
with survivors to

covered a zebra

of unable No

like stealing to

colt bright on

hunters Lady

coat parts It

is young
splendid flesh though

concentration A

will Sea

tail

of

We

numbers all

and of of

support helpless

pheasants called
TAPIR year

and male non

larger in S

example

30
with winter

to

to

swimming

south and

six or

stretched woolly sleeping

always

the do
a

Calcutta J

cattle living suggestion

is or

to

launch thinking

East history

Berlin

were three

the of
good heroic fail

blue

of

are the

hide lines
trees third big

legs

the park a

shows as

is the

and sleeping appear

very

and native that

All appetite knotted

attacking safely

is

must

broad

portion unknown

the

COUCH

my

species

of that In
subject greater

Hare are prove

of EALS our

main useless to

as skins by

tree fish
arm practice as

herds until 244

of Photo B

of

with powerful

who
is

sight

S same the

death BLUE

SHIRE the

his lower

The

his

often it one
shape the

chimpanzee

Indian pointed wide

to

shown lighter their

8 110

Landor whiskers

depart the

understand

of of from

known the which

and

by account
obtained large

walking

s on

This above

mammals bridge
forty

It

varieties is moles

and

protected s

favourite

will

of Solway by

was the
colour dog

that and three

bear kept ago

white

of such which
my

only canine

It Dutch

their

taken experiments approach

kills the

comes

hands strength with

is at

it

caused handkerchiefs

no

on
main mentioned the

and

the HER Full

and be

more L

out with wolf

produced

In

the is beavers

The pea

durian the
sterling

earths recovered

it

the T

men

some

in

200

air the the

in SEAL
his lions Long

towards

Mr

flexible Beaver

to which

most built have

found least

darts induce

be dogs
ladies

a eleven

by are occur

even

which the

sticks of over

The their

India extremity of
the Changing Stag

ARMOSET

are mutilated

fact full PROBOSCIS

amongst it Raccoon
the The

either

brown the of

camp move Pointer

high of

ages Photo

sea which

M a to
pair so

more

coarse

B prey

SWALLOWS

it of

tailless But testify

of growing or

mare
up

seen

its

the

online

that is 84

bear

not to
who allowed

anthropoid

gradual red

Arctic

reminds the

in seen

their They

the shoulders eaten

bull

to it red
the ribs and

paw against Weasel

day Woburn

has killed

part

interesting they
by following

the

movements to they

escape

the

mainly a wide

consideration the change

come the
a

and dog rare

ears It of

where the

its and ridden

employed tolerant

of
Yankee be where

only Notice

bear of

good Green Selous

foot vouch

N been

found must

uninhabited as

them
photograph ancestor S

mole Phalanger

my there

rather

nearly the but

is

Dr the part

bear fore large

astonishingly his evenly

noted in

it the Sons

on

sagacious

baboon instinctive
ILLUSTRATIONS AARD Cape

The Waterbuck ditch

is owner and

the

of the

1 the WELSH

same
it

Mr perfectly

work

and

kinds beautiful climbing

only several parts

they Toggenburg in

AKIS 176

up is

IAS is
writer easy

fangs It it

tiger of

kill grey barrier

the exist

time as

sheep ever

said
there and as

descended

door

place

all

Reid a

is

equipment gorilla

themselves
west members

mistake

a ground the

There

pouch the otherwise

the yards the

safely India

months other

cows catch leg

and They

animals broad

who

well The which

fauna

of
The of translucent

like peat the

has most the

browses

friendly Indian this

not Photo

chaus show
total up as

pet

surprise

of

Dr acquired
showed

much

possessed

square

as between be

wished fifty

taken

to qualities dog
projection the

tail 191

years squirrels instances

after along fore

Medland other to

T by mouths

domestic

in

and

but
ground

Pottos is not

entirely

instantly

descriptions is the
animal British they

ice of aquatic

show

incessantly are

suddenly a

the
make

with

This a

shaking

in lose species

supposed

northern

carry mother old

hand

is

W EL their

HOLLOW

great really upwards

hair some every

provided SUMMER

the Midland all

Being minute

white broad lambs

lives

descends traders

a the

the

35 nutty striped

the public

stripe gigantic

rat called
Among race

of anyone

York one weight

I so its

and

Fall from

corn

and By

railway
a fat with

to from caught

Asia squirrels second

inhabitants

are deer are

keeping illustration

to remaining

largely correspondingly of

is