Agilent OpenLab CDS
Version 2.4
Release Notes
Notices
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Contents
Contents
Introduction 4
For our Regulated Customers 4
OpenLab CDS 5
Version 2.4 5
Version 2.3 11
Version 2.2 14
Version 2.1 17
Version History 21
OpenLab CDS Release Notes 3
Version 2.4
Introduction
This document provides a listing of the major feature modifications made in
each release of OpenLab CDS Software including selected add-ons.
References to product documentation regarding known issues and
workarounds are also provided.
For our Regulated Customers
When any change is made to Agilent software, the validation status of the
software needs to be re-established by the user/customer.
Whenever software is changed, a validation analysis should be conducted
not just for the validation of an individual change, but also to determine the
extent and impact of that change on the entire software system.
OpenLab CDS Release Notes 4
Version 2.4
OpenLab CDS
Version 2.4
Infrastructure Support
OpenLab CDS version 2.4 is supported in the following configurations:
Workstation Plus, Workstation with file-based storage, and Client/Server.
Workstations, Clients and Agilent Instrument Controllers (AICs) are
supported on:
Windows 10, Enterprise or Professional, 64-bit (version 1703, 1709,
or 1803) 1
Windows 7 SP1, Enterprise or Professional, 64-bit
Additionally, for networked deployments, clients and AICs are supported on:
Windows Server 2012 R2, Standard or Datacenter, 64-bit
Windows Server 2016, Standard or Datacenter, 64-bit
New support for OpenLab ECM as networked security repository for
OpenLab CDS. Supported OpenLab ECM software:
OpenLab ECM Version 3.5 Update 6 or later is required
OpenLab ECM Version 3.6
No operating system support has been removed since v2.3.
Acquisition
Priority sample submission
Ability to add priority sample. Users can submit priority samples that
will acquire after the current injection is completed.
1 for support of the most current versions check with your Agilent representative
OpenLab CDS Release Notes 5
Version 2.4
Edit pending sequences
Ability to edit pending sequence. Users can preview the pending
sequence and modify all pending lines of the sequence without
disruption to the run queue.
Support for multiple gain acquisition with LC/MSD
Ability to acquire data with different gain settings for the same mass
to allow increased throughput (see LC/MS Driver Update for details).
SIM ion override
Allows users to specify target SIM Ion other than what is currently
defined in the acquisition method at time of sequence submission.
Reasons for aborting (see Data Integrity Enhancements for details)
Control client (see Data Integrity Enhancements for details)
Data Analysis and Reporting
Support for MS profile mode
Acquire and view MS data in profile mode with quantitation through
extracted chromatograms from spectrum peak.
Improvements to custom calculator expression editor
Adoption of common scripting standards to provide improved
readability
Autofill and error highlighting
Indenting and inline help
Multi MS library searching
Ability to select up to 10 libraries in processing method to search
spectrum in the NIST format Library
OpenLab CDS Release Notes 6
Version 2.4
Automated batch export functionality of CSV file
CSV file includes mass, peak area, peak height and retention time.
Automatic calculation of UV purity sensitivity value
Ability to have the purity threshold calculated automatically for all
compounds in the method based on the sensitivity set for a
compound.
Signature order and locking results on sign (see Data Integrity
Enhancements)
Data Integrity Enhancements
Improved signature workflow support
Ability to enforce customizable signature paths
Ability to approve/reject multiple at the same level
Signature order and Locking results on sign
Administrators now have the ability to configure and enforce a
signature order. When enabled, signatures in Data Analysis will have
to follow the order and meaning as prescribed in the project’s
signature settings. An additional enhancement in the Signature
Settings page allows for all results to be automatically locked upon
the first signature.
Reasons for aborting
If reasons are enabled for Results modification, the user will now be
prompted for a reason when they intentionally abort a run queue
item.
Obscure Locked Windows
If OpenLab CDS is locked, the text in the application is blurred in the
event that it may be displaying confidential or sensitive information
in its tests or descriptions.
OpenLab CDS Release Notes 7
Version 2.4
Control Client
In a multi-user environment, users with the privilege to manually
control an instrument can “take control” of an instrument to modify
its settings. Other users can still submit runs to the instrument run
queue, but only one user can be modifying these settings at a
time. This reduces mistakes in user overlap and allows changes to
the instrument settings to be correctly attributed to the person who
is in-control.
Add-ons
Introduction of QualA add-on for OpenLab CDS WorkStation Plus and
Client/Server
New software qualification tool allowing customers to self-perform
software qualification assessments for future minor software
releases.
Version 1.4 of Migration Tools for OpenLab add on to support workstation to
workstation upgrades to CDS 2.4 from the following software:
ChemStation C.01.05, C.01,06 or C.01.07
EZChrom A.04.05, A.04.06 or A.04.07
Support for creation and automated export of Allotrope files in OpenLab CDS
WorkStation and Client/Server software. The Allotrope Data Format (ADF)
files are a universal data format, a detailed description of the Allotrope Data
Format and its structure is available on the Allotrope Foundation web site
(https://www.allotrope.org).
• Automated creation of Allotrope Data Format when result
set/injection completes. Consists of the LC-UV analytical raw data
(chromatograms + spectra) plus metadata and the original OpenLab
CDS files.
Manual export of result set or sequence
OpenLab CDS Release Notes 8
Version 2.4
Driver Updates
Agilent Instrument driver packages shipped with OpenLab CDS 2.4
RC.NET Instrument Driver Driver Software Revision Installed by
default with
OpenLab
CDS 2.4
Agilent LC A.02.19 SR3 x
Agilent ELSD A,01.07 (build 12)
Agilent LC/MS SQ 2.2.2260 x
Agilent GC 3.0.532 x
Agilent GC/MS SQ 1.3 (build 54) x
Agilent 490 Micro GC B.01.12.1.2125
Agilent Headspace B.01.07.3
Agilent 35900E A/D Converter 2.3 (build 53) x
Agilent SS420X A/D Converter A.01.01 (build 65) x
Agilent Data Player 2.2.6 x
Agilent CTC PAL 3 A.01.04.1
Agilent CTC PAL-xt B.01.08
Non-Agilent Instrument Control Drivers
For the most current list of supported non-Agilent instruments visit the
OpenLab CDS product page at: www.agilent.com/chem/openlabcds
LC/MSD Driver Update
Method Editing with Gain
Method editing now supports Gain instead of EMV. EMV from
previous methods will be reset to Gain=1. Using constant gain in
methods relieves the user from controlling delta EMV change in a
regulated environment.
Two Scan Types with Method Manual Resolution
OpenLab CDS Release Notes 9
Version 2.4
The driver now designates two scan types: Single Ion Monitoring
(SIM) and Scan. The “Scan” scan type will persist throughout the
run. If there are Scan method discrepancies, the Manual Resolution
window with hover-over tips will appear for users to adjust their
method. Additionally, users can check the “Target points per
second” box to specify the number of points across the peak. The
driver software will automatically calculate the scan time and dwell
time to meet the “Target points per second” setting.
Time Segments in Audit Trail but Not in UI
Since the scan will be run throughout the time segments, the audit
trail reflects time segment changes although the UI no longer shows
time segments as an option.
Distinguishing Scan Traces with Overlapping Masses
When there are overlapping masses in multiple “Scan” scan
segments and if all the parameters (fragmentor, gain, polarity) are
the same, users will not be able to distinguish the scan trace that
the overlapped mass came from in Data Analysis. If any of the
above parameters is different, users will be able to distinguish the
spectrum data based on the parameters shown in DA.
OpenLab CDS Release Notes 10
Version 2.3
Version 2.3
OpenLab CDS version 2.3 is supported in the following configurations:
Workstation Plus, Workstation with file-based storage, and Client/Server.
Workstations, Clients and Agilent Instrument Controllers are supported on:
Windows 10, Enterprise or Professional, 64-bit, version 1607 or later
Windows 7 SP1, Enterprise or Professional, 64-bit
Licensing updates
OpenLab CDS version 2.3 requires an update to the license file from
SubscribeNet when upgrading.
Functional verification following upgrade installation
Acquisition
LC shutdown options in run queue allows users to set shutdown actions
Shifting of runs/sequences in the run queue
Users can edit the order of pending items in the run queue.
Ability to display all users currently using the same instrument
Automated sequence summary report
Ability to specify the sequence summary report(s) at the time of
sequence submission.
Graphical display of sample location
Optionally display the location of your samples in a sequence table
when using most Agilent LC injectors.
OpenLab CDS Release Notes 11
Version 2.3
Data Analysis and Reporting
Extract 2D (UV) signal from 3D matrix
Ability to define specific chromatogram extraction parameters and
identify and quantify compounds from extracted chromatograms.
Isoplot UI for interactive spectra and signal extraction
Ability to display a 3D UV matrix as an isoplot and to provide tools
for method optimization.
MS peak purity
MS Peak Purity for SCAN and SIM/SCAN data. Users can setup in
the processing method to calculate MS peak purity for identified
peaks or all peaks.
Mass annotation
Ability to label the UV and MS chromatogram peaks with base peak
m/z.
Chromatogram smoothing
Ability to setup the smoothing parameters in the processing
method.
Loading methods from another project
Allows authorized users to browse to another project, open a
method and save a copy of that method to their current project or
link it to a result set.
Overlay chromatograms from different projects
Allows users to load data from other projects to compare results.
MS tune report
Ability to display the MS tune report for selected injection from the
injection tree.
Enhanced conditional formatting and Reporting
Improved conditional formatting for tables, fields, and matrix
including multiple color choice.
Automated export of ChemStation and AIA Files
Ability to define automatic export of raw data (ANDI/AIA, CH) during
a running sequence as part an automatic processing method.
OpenLab CDS Release Notes 12
Version 2.3
Load ChemStation/EZChrom Method
Users can open a result set from ChemStation or EZChrom (option
to have multiple methods imported and linked automatically).
OpenLab CDS data analysis updated to true native 64-bit support for
handling of large files/data.
Driver Updates
Driver packages (revision) installed with OpenLab CDS version 2.3:
Agilent LC A.02.19
Agilent LC/MSD A.01.02.35
Agilent GC B.01.03
Agilent GC/MSD A.01.02
Agilent 35900E A/D 2.3.0
Agilent SS420x Interface A.01.01
Agilent Data Player A.02.01
Other RC.NET drivers included on USB media:
CTC PAL3 A.01.04
PAL XT B.01.08
ELSD A.01.07
Agilent 490 Micro GC 1.12.3
Agilent Headspace B.01.07.2
Non-Agilent Instrument Control Drivers
For the most current list of supported non-Agilent instruments visit the
OpenLab CDS product page at: www.agilent.com/chem/openlabcds
OpenLab CDS Release Notes 13
Version 2.2
Version 2.2
Infrastructure Support
OpenLab CDS version 2.2 is supported in the following configurations are
Workstation Plus, Workstation with file-based storage, and Client/Server.
Workstations, Clients and Agilent Instrument Controllers can run under the
following:
Windows 10, Enterprise or Professional, 64 bit
Windows 7 SP1, Enterprise or Professional, 64 bit
Windows 8.1, Enterprise or Professional, 64 bit
Acquisition
Automated creation of sequence result folder and name
Project enhancements supporting template file sharing
Ability to share sequence and templates within multiple projects.
Failover state for operational continuity
Allow submission of samples through the AIC in case of network
connectivity failure occurs.
Method translation from 68xx to 78xx and Intuvo
Ability to open acquisition method created on a 68xx and use on 78xx or
Intuvo.
Data Analysis
Snapshot via Data Analysis
Ability to view, process and print from a sample that is being acquired.
Translation and import of MSD ChemStation data format to OpenLab CDS
Enhancement to user permissions and version access in Data Analysis
Auto-lock result set when e-signing
OpenLab CDS Release Notes 14
Version 2.2
Version label will not change when a result set is signed or locked
User can sign a locked result set
Load older version of a processing method & single run result sets where
available
Enhancements to user privilege control for MS functionality
Enhancements to reporting
Zoom in/out of report preview with mouse wheel
Ability to add any data field in header or footer
Use of complex custom fields in filter, grouping and sorting expressions
More formatting settings for custom tables
New option to remove duplicate peaks when using named groups
Ability to define sorting of a repeated table
Integrated template documentation tool
Allows the template author to document the design of the report template.
Enhancements for MS data include:
Report single values of method override parameters in table and single
fields
Print graphical qualifier results (limit lines) and missing qualifiers
Add-ons
The following add-ons are supported with OpenLab CDS (*additional licenses may
be required):
Support for Sample Scheduler for OpenLab
Support for Gel Permeation Chromatography (GPC)* add-on
Manual export of data files in legacy formats:
ChemStation Edition *.D (including ch)
AIA
Support for Match Compare for OpenLab*
OpenLab CDS Release Notes 15
Version 2.2
Driver Updates
Driver packages (revision) installed with OpenLab CDS version 2.2:
Agilent LC A.02.16.6
Agilent LC/MSD A.01.02
Agilent GC B.01.02
Agilent GC/MSD A.01.01
Agilent 35900E A/D 2.3.0
Agilent SS420x Interface A.01.01
Agilent Data Player A.01.02
Other RC.NET drivers included on USB media:
CTC PAL3 A.01.03
PAL XT B.01.08
ELSD A.01.07
Agilent 490 Micro GC B.01.12
Agilent Headspace B.01.07.2
Non-Agilent Instrument Control Drivers
Includes driver support for Waters e-Alliance, Alliance, Acquity and Acquity
H-Class LC instruments
Includes support for Bruker/Varian CP-3800/3900 and Scion 430/450/456
GC instruments
Includes support for Valco Instruments Valves: EMHCA-CE, EMHA-C,
EMTCA-C
Includes support for Shimadzu GC and LC instruments
Includes support for Thermo Accela / Surveyor LC instruments
OpenLab CDS Release Notes 16
Version 2.1
Version 2.1
Infrastructure Support Changes
OpenLab CDS Workstation
Introduction of a second Workstation product: File based Workstation
(secure/non-secure). In addition to the Workstation Plus (with Content
Management – formerly referred to as “OpenLab CDS Workstation”) a new
lower footprint Workstation with file-based storage is now available.
Optionally the project folders can be protected against modifications from
outside OpenLab CDS.
Windows 10 support
Workstations, Clients and Agilent Instrument Controllers can run under
Windows 10 (Windows 7 and 8.1 still supported).
Acquisition
Dual simultaneous injection
User can create a dual simultaneous sequence for high throughput on a
dual tower Agilent GC.
Dynamic instrument configuration
User can perform limited configuration changes to the configured
instrument from within the acquisition client without reconfiguring the
instrument from Control Panel, such as LC autosampler capillary
configuration, GC inlet liner and syringe configuration, GC column
configuration, moving injector from front inlet to back inlet on a 7890 GC
etc. With this feature, the instrument also does not need to be reconfigured
after firmware updating.
Printing from Acquisition client:
Previewing and printing acquisition method and sequence table from
acquisition client is available. Acquisition method and sequence table need
to be saved to allow printing. User can save both report as PDF, word, or
excel, alternatively, print from a printer. Configuration report printing is also
allowed from instrument status dashboard.
OpenLab CDS Release Notes 17
Version 2.1
Method parameter overriding capability:
LC/MS Acquisition Method Override Columns (source parameters and
fragmentor) and Compound Amounts are columns introduced in sequence
table where users can override the method parameters during acquisition
or for post run data processing.
Simultaneous SIM & SCAN acquisition for LC/MS
Lamp off after run:
Introduced a global instrument setting that allows to automatically turn LC
detector lamps off after a definable idle time after a run.
Data Analysis
Blank subtraction
Use the blank subtraction to calculate a clean chromatogram with
contribution of the analytes only.
Qualifier ion support
The presence of qualifier ions in the correct amount relative to the target
ion gives evidence of correct target compound identification.
Store manual integration in method
Ability to copy manual integration corrections into the linked Processing
Method.
DA search tool
On Workstations w/ Content Management and Client/Server systems,
users can search results by text or by time period.
Higher quality reports
Vector graphics replace bitmaps (chromatograms and spectra). Added
long term storage pdf report format (PDF/A-1b format).
OpenLab CDS Release Notes 18
Version 2.1
Driver Updates
All driver packages are updated to new software revisions. Some new RC.net
Drivers are included:
Driver packages (revision) installed with OpenLab CDS version 2.1:
Agilent LC A.02.14
Agilent LC/MS SQ A.01.01
Agilent GC A.03.02
Agilent GC/MS SQ A.01.01
Agilent 35900E A/D B.01.01.15272
Agilent SS420x Interface A.01.01
(NEW)
Agilent Data Player A.01.02
Other RC.NET drivers included on USB media:
CTC PAL3 A.01.03
PAL XT B.01.08
ELSD A.01.05
Agilent 490 Micro GC B.01.12
Agilent Headspace B.01.07
Non-Agilent Instrument Control Drivers
Includes driver support for Waters Acquity and Acquity H-Class systems (v
A.1.2)
Includes support for Bruker/Varian CP-3800/3900 and Scion 430/450/456
GC instruments (A.02.01)
Includes support for Valco Instruments Valves: EMHCA-CE, EMHA-C,
EMTCA-C (A.01.01)
Further 3rd party instrument support (released independently and not on
CDS 2.1 install media)
Shimadzu GC and LC (planned)
OpenLab CDS Release Notes 19
Version 2.1
Thermo Accela / Surveyor LC (planned)
Waters e-Alliance LC (planned)
OpenLab CDS Release Notes 20
Version 2.1
Version History
For known issues and workarounds in the OpenLab software at the time of release
see the Software Status Bulletins, which can be found online at:
http://www.agilent.com/en-us/support/software-informatics/openlab-software-
suite/openlab-chromatography-data-system-(cds)/m84xx
You may also visit www.agilent.com for up to date issue information for all Agilent
software products.
OpenLab CDS Release Notes 21
In This Book
This document provides a listing of the major
feature modifications made in each release of
OpenLab CDS Software.
www.agilent.com
© Agilent Technologies, Inc. 2019
Edition 02/2019
M84410-90011
