This document describes the process of human development from conception through the fetal period. It begins with an overview of the female reproductive system and egg maturation and ovulation. It then discusses fertilization, where the sperm and egg unite to form a zygote. The zygote undergoes cell division and implants in the uterus, initiating pregnancy. The stages of development are described, from the germinal period in the first 10 days through the embryonic period from weeks 2-8 and the fetal period from weeks 8 until birth. Key developmental milestones are outlined for each week such as organ formation, growth of limbs and digits, and the beginnings of brain waves and heartbeats.
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Conception and Pregnancy
This document describes the process of human development from conception through the fetal period. It begins with an overview of the female reproductive system and egg maturation and ovulation. It then discusses fertilization, where the sperm and egg unite to form a zygote. The zygote undergoes cell division and implants in the uterus, initiating pregnancy. The stages of development are described, from the germinal period in the first 10 days through the embryonic period from weeks 2-8 and the fetal period from weeks 8 until birth. Key developmental milestones are outlined for each week such as organ formation, growth of limbs and digits, and the beginnings of brain waves and heartbeats.
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Life begins in the reproductive
system of the female, set inside
the pelvic cavity. The term natal means birth so pre-natal means before birth. Ampulla Fimbria . Ovum is ripening inside follicle Endometrium (uterine wall) Maturing follicles Cervix a mucous plug forms in this area during pregnancy
Vagina Fallopian Tube Ovary Uterus (womb) Egg maturation and ovulation is stimulated by two hormones secreted by the pituitary gland- follicle stimulating hormone (FSH) and luteinizing hormone (LH). Approximately every 28 days, at the start of a cycle, these hormones cause several follicles to start growing. Of these, only one matures to form a large fluid- filled structure that contains a ripening egg. When the egg matures it is released from the follicle when the follicle rupturesin a process called ovulation. This occurs on about the 14 th day of the cycle. The egg contains 23 chromosomesthe mothers genetic material. The egg, or ovum, slowly travels through the fallopian tube, and if sperm are present at that location, one may unite with the ovum in a process called fertilization. Only one sperm can enter the eggs outer membrane. The moment the sperm penetrates the egg is called conception, creating a new and separate cell called the Zygote. The penetrating sperm loses its tail, the head dissolves, and out spills its genetic material23 chromosomes. Stage 1 Germinal Period
(Conception to 10 days) Did You Know? 7 From day 1 at conception, all the information needed to become a person, is already present (e.g. colour of eyes, sex, etc.); Except for oxygen & nutrition, nothing more is added to ensure growth and maturity into a perfect baby. The fertilized egg now has 23 PAIRS, or 46 chromosomes. Immediately the cell begins to duplicate, taking approximately 30 hours to complete the first cell division. At an increasingly faster rate, new cells are added until they form a hollow, fluid-filled ball, called a blastocyst (about 4 or five days after conception). Approximately 60 to 70 cells form the blastocyst. Those on the inside (called the embryonic disk) will become the new organism whereas those on the outside will provide the protective covering. Multiple births can occur two different ways. Sometimes two (or more) different eggs are released, and both are fertilized by two different sperm. The result is fraternal twins. They may be both boys or both girls or one of each; they may or may not look similar. In other cases, a single egg fertilized by a single sperm will split completely in half during that very first cell division. This results in identical twins. They will both be of the same sex and will look very similar if not the same. Identical twins have identical DNA, but different fingerprints! Around the seventh or ninth day after conception, the blastocyst burrows into the uterine lining in a process called implantation. The protective covering quickly develops into the amnion, surrounding the organism in amniotic fluid. A yolk sac also develops, producing blood cells until the liver, spleen, and bone marrow is mature. The womans ovaries produce massive doses of the hormone progesterone, signaling the body that a pregnancy is in progress. All the time an egg has been ripening and preparing for ovulation, the endometrium of the uterus has been forming a nutrient-rich lining. It is preparing to receive a fertilized egg. (If no egg is fertilized, this lining will leave the body during a process called menstruation.) Stage 2 Embryonic Period
(2 to 8 weeks) Nerve growth begins when a sheet of cells on the back of the embryo folds in the middle to form a tube, which will become the future spinal cord. At one end tube enlarges to form the brain's major sections. The amniotic fluid that cushions the fetus begins to form. 14 Fetal brain begins to form on day 23 Brain waves produced by 6 weeks Fetal heart begins to form 18 days after conception Measurable heart beat 21-24 days after conception 5 weeks - At this time the embryo is still the size of a raisin. Low on the sides of the head are two folds of tissue that will become the ears. Although not completely developed, all the major body organs and systems are formed. The neural tube enlarges into three parts, that will soon develop to become a very complex brain. Also the placenta begins functioning, including the chorionic villi and the umbilical cord, through which the baby will receive nourishment and oxygen. The spine and spinal cord grows faster than the rest of the body at this stage and will give the appearance of a tail. This disappears as the baby grows.
6 weeks - The embryo itself is about a 1/4 inch long. Other major organs, including the kidneys and liver, have begun to develop, and the neural tube, which connects the brain and spinal cord, closes. The physical sensations of pregnancy start--nausea, fatigue, sore breasts and frequent urination. 16 The brain has developed into 5 areas and some cranial nerves are visible. Arm and leg buds are visible and the formation of the eyes, lips, and nose has begun. 7 weeks - The embryo's hands and feet are shaped like paddles, but the fingers are beginning to take shape. The embryonic tail has almost disappeared. The pituitary gland is also forming and the fetus is beginning to grow muscle fibers. The heart has divided into the right and left chambers and is beating about 150 beats a minute which is about twice the rate of an adult. The baby's facial features are visible, including a mouth and tongue. The eyes have a retina and lens. The major muscle system is developed, and the baby starts to practice moving. The baby has its own blood type unique from the mother's and the blood cells are produced by the liver now instead of the yolk sac. 18 Major organs have all begun to form. Hair follicles and nipples form and knees and elbows are visible. 19 The embryo is reactive to its environment inside the amniotic sac where it swims and moves. Hands and feet can be seen. At the end of week 8, the embryonic period is over and the fetal stage begins. 20 Years ago, while giving an anesthetic for a ruptured tubal pregnancy (at two months) I was handed what I believed to be the smallest human being ever seen. The embryo sac was intact and transparent. Within the sac was a tiny human male, swimming extremely vigorously in the amnionic fluid, while attached to the wall by the umbilical cord. The tiny human was perfectly developed, with long, tapering fingers, feet and toes. The baby was extremely alive and did not look at all like the photos and drawings of 'embryos' which I have seen. When the sac was opened, the tiny human immediately lost its life.
- Paul E. Rockwell, M.D. (8 weeks) Stage 3 Fetal Period
(8 weeks-birth) FETAL PERIOD o This is the final stage of gestation. The developing organism now, is called a FETUS. o The fetal period differs from the embryonic period in several fundamental ways. o During this period, the organs and body systems become more complex. o Right up to birth, finishing touches, such as fingernails, toenails and eyelids develop.
o The fetus is very active, moving its arms and legs, opening and closing its mouth, and moving its head The mother can feel the jerky and squirmy movements around the 4th month o Between the 4 th and 6 th months, there is a decline in the fetus activity
The decline corresponds to the development of the higher regions of the brain responsible for more controlled and coordinated motor activity
Evidence indicates that fetal activity is crucial for normal development of limbs and joints Placenta Umbilical cord Amniotic sac filled with amniotic fluid
Mucous Plug 8 weeks- The unborn baby is now called a fetus. The fetus is protected by the amniotic sac and filled with fluid. Inside the child swims and moves gracefully. The fetus is now about 3/4 inches long. The arms and legs have lengthened. During this time of development, the baby's head appears much larger than the body because the brain is growing very rapidly. Brain waves can now be measured. The teeth and the palate are beginning to form and the larynx is developing. Through its parchment-thin skin, the baby's veins are clearly visible. By the eighth week the ears begin to take shape.
9 weeks - Though the fetus is constantly moving, fetal movement is not felt, for several more weeks. All of the organs, muscles, and nerves are in place and beginning to function. As the hands and feet develop fingers and toes, they lose their paddle-like look, and the touch pads on the fingers form. 28 "A person's a person, no matter how small!" -Dr. Seuss This is a foot of a 9 week old fetus. At this stage in the pregnancy there are already footprints and fingerprints. 9 weeks 10 weeks - The heart is almost completely developed and very much resembles that of a newborn baby. The eyelids have fused shut. The wrists and ankles have formed and the fingers and toes are clearly visible. 11 weeks - The vital organs--the liver, kidneys, intestines, brain and lungs--are fully formed and may begin to function, while the the head is almost half the length of the entire body.
30 .
11 weeks Nearly all structures and organs are formed and beginning to function. Fingers and toes have separated. Take a glimpse at how incredibly precious the childs tiny feet are at this point. Hair and nails begin to grow. The genitals begin to take on the proper gender characteristics. It will be just a few more weeks before an ultrasound can show if the baby is a boy or a girl! Amniotic fluid begins to accumulate as the kidneys begin to function. This fluid, consisting primarily of water, helps provide a cushion for the baby within the womb. The muscles in the intestinal walls begin to practice contractions that digest food. The baby is only about 4.1 cm (1.61 inches ) long and weighs 7gm (0.25 ounce) but it is busy moving and kicking. Month 3 Twelve Week Fetus The eyelids now cover the eyes, and will remain shut until the seventh month to protect the delicate optical nerve fibers. The hair is on the head and the fingers and toes have developed soft nails. The kidneys are developed and begin to secrete urine. The skull is not solid bone, but has formed in sections. These sections can overlap during the birth process. There are even a couple of soft spots where bone has not formed at all called fontanelles. THIS IS THE END OF THE FIRST TRIMESTER, WHEN THE MAIN TASK WAS FORMATION! During this first trimester period of formation, many things can go wrong. Sometimes the womans body will self- abort. This is called a miscarriage. 34 The heart is almost completely developed and the heart rate can be heard on a Doppler machine at the doctor's office. Most major organs and tissues have developed. The face is well formed and the eyes are almost fully developed. Arms, hands, fingers, legs, feet, and toes are fully formed. Nails and earlobes start to form and tooth buds develop in the gums. Fetus can make a fist with its fingers. Heartbeat 12 wks Vocal chords are complete, and the child can and does sometimes cry (silently).
The brain is fully formed, and the child can feel pain.
The fetus may even suck his thumb
The baby can also squint and swallow and is sensitive to heat touch light and noise. 35 12 weeks - cont Month 4 Four months (16 weeks) Sixteen Week Fetus By now, the fetus has grown large enough that the movements can sometimes be felt by the mother. Often felt like a flutter or a "flip-flop", these first movements that can be felt by the mother is called quickening. 39 This baby is about 13 weeks old, though the skin is still somewhat transparent, you can see veins and nerves, formed ears and fingers. The baby even at this small stage, feels comfort in sucking their thumb 13 weeks By 14 weeks, the baby has formed muscle systems and the mother can feel it kick. At 15 weeks the baby has taste-buds and can even taste the mothers meals. 40 At 16 weeks, they have eyelashes, eyebrows and fine hair. 14 weeks 16 weeks At the end of the fourth month, white, downy hair called lanugo (lu- noo- go) covers the entire body of the fetus. It provides warmth, since the fetus has no layer of fat beneath the skin yet. At some point later, a white waxy, cheese-like substance also forms over the entire surface of the skin. This is called vernix caseosa. The vernix is a perfect skin lotion, which along with the lanugo, protects he skin from the constant exposure to amniotic fluid. It is also believed that it serves as a sort of skin cleanser and antibacterial substance. The lanugo and vernix caseosa diminishes in amount during the last weeks of the gestation period and usually rubs off during delivery. The presence of a great deal of vernix or lanugo at the time of birth, therefore, is often a sign of prematurity. Month 5 Five months (20 weeks) Twenty Week Fetus 17 weeks 45 Ultasound - view the heart beating and mouth opening During the 5 th month, at 22 weeks, the fetus weighs a little over 1 pound, and is about 1 foot in length. At this time, the movements can clearly be felt by the mother and by others who place their hands over the mother's abdomen. The fetus also has a number of sensory capacities. However, it still has a long way to go before it is mature enough to survive outside of the womb. Although there are a few cases of infants being born and surviving at this time, the chance of survival (and without later complications), is very slim.
Around 5 months after conception, the fetus develops a sense of balance and starts noticing changes in the mothers posture.
Toward the end of pregnancy, fetus is able to respond to light and may actually see light through the stretched wall of the mothers abdomen. The fetus also shows a sensitivity to light and can be stimulated and irritated. Sensory capacities of the fetus From 4 months onward, fetuses hear and respond to loud noises in the outside environment, in the uterus, especially their mothers voices.
But the sounds are muffled by background noise.
Sensory capacities of the fetus (Contd.) Month 6 Six months (24 weeks)
During the 4 th -6 th months, most of the organs that were formed during the first trimester begin to function. If born at this time, the fetus has a chance of survival. The point in which it can first survive is referred to as the age of being viable and occurs sometime between 22 and 26 weeks. THIS IS THE END OF THE SECOND TRIMESTER, WHEN THE MAIN TASK WAS FUNCTIONING! Month 7 7 th month (28 weeks)
THIRTY WEEKS FETUS At only about 3 pounds, the 7 month old fetus has a few pounds to go before reaching the average 7.5 pounds. During this time, the brain continues to develop at an increasingly fast rate. By 7 months, the fetus clearly responds to sounds outside of the womb, and develops a preference for the tone and rhythm of its mother's voice. Month 8 8 th month (32 weeks) THIRTY SIX WEEKS FETUS By the eight month, the fetus has little room for large movements. During this month, a layer of fat is added that will assist with temperature regulation. The lungs however, still remain immature. If born at this time, the infant will likely require some help with breathing. It is not until the ninth month that the lungs are mature enough to regulate breathing without assistance. Month 9 9 th month (38 weeks) During this last month of the gestation period, baby continues to grow at a rate of to 1 pound per week. Baby will turn around in the womb, to a head- down position. The lungs are maturing, preparing for that first breath. THIS IS THE END OF THE THIRD TRIMESTER, WHEN THE MAIN TASK WAS GROWTH! Learning during fetal period DeCasper and Spence study
Pregnant mothers read aloud a passage from a storybook twice a day in the last month and a half.
Newborns change their sucking rates (either increase or decrease from the baseline) in order to be able to hear the same passage. Learning during fetal period (cont.) Another study showed that fetus heartbeats decreased when the same story was played, indicating increased attention. A different story lead to no changes in the heartbeat.
Evidence that newborns and fetus recognizestories read to them repeatedly. Salk experiment
Fetus learn about normal heartbeat in the womb.
Newborns get irritated when made to listen to higher beats per minute than the mothers heartbeat. Learning during fetal period (cont.)