Scribd
Upload
119 views15 pages

Anaphylaxis Shock: Bagian Anestesi FK UNISSULA Semarang

Anaphylaxis shock is a severe, life-threatening systemic hypersensitivity reaction that can cause rapid airway and breathing problems and circulation issues. Common triggers include foods like peanuts, drugs like antibiotics and anesthetics, and insect venom. Fatal reactions can occur within minutes depending on the trigger. The pathophysiology involves immunologic activation of mast cells and basophils by IgE antibodies leading to release of histamine and other mediators causing bronchospasm, vasodilation, and decreased heart function. Recognition and treatment follows an ABCDE approach of assessing airway, breathing, circulation, disability, and exposure problems, with adrenaline, oxygen, fluids, antihistamines, corticosteroids, and other

Uploaded by

Teguh Pambudi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
119 views15 pages

Anaphylaxis Shock: Bagian Anestesi FK UNISSULA Semarang

Anaphylaxis shock is a severe, life-threatening systemic hypersensitivity reaction that can cause rapid airway and breathing problems and circulation issues. Common triggers include foods like peanuts, drugs like antibiotics and anesthetics, and insect venom. Fatal reactions can occur within minutes depending on the trigger. The pathophysiology involves immunologic activation of mast cells and basophils by IgE antibodies leading to release of histamine and other mediators causing bronchospasm, vasodilation, and decreased heart function. Recognition and treatment follows an ABCDE approach of assessing airway, breathing, circulation, disability, and exposure problems, with adrenaline, oxygen, fluids, antihistamines, corticosteroids, and other

Uploaded by

Teguh Pambudi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
You are on page 1/ 15

ANAPHYLAXIS SHOCK

Bagian Anestesi FK UNISSULA Semarang


DEFINITION
The European Academy of Allergology and Clinical
Immunology Nomenclature Committee

ANAPHYLAXIS is a SEVERE, LIFE-
THREATENING, GENERALISED or SYSTEMIC
HYPERSENSITIVITY REACTION

RAPIDLY, LIFE-THREATENING AIRWAY AND/OR
BREATHING AND/OR CIRCULATION PROBLEMS

Usually associated with skin and mucosal change

TRIGGERS
FOOD
peanut

DRUGS
antibiotics, anesthetic drugs, NSAID,
contrast media

VENOM

MORTALITY
Risk factor
ATOPIC, ASTHMA

Time course for fatal reaction:
Food : 30-35 min
Insect stings : 10-15 min
i.v. drugs : 5 min
PATOPHYSIOLOGY
Immunologic
Ig-E binds to the Antigen activates receptors
mast cells & basophile histamine
contraction of bronchial smooth muscles >>,
vasodilation, leakage of fluid from blood vessels
>> and cause heart muscle depression

Non-immunologic
directly cause the degranulation of mast cells &
basophiles

RECOGNITION
A-B-C-D-E APPROACH
AIRWAY PROBLEMS
airway swelling, hoarseness, stridor
BREATHING PROBLEMS
shortness of breath, wheeze, cyanosis
CIRCULATION PROBLEMS
signs of shocks cardiac arrest
DISABILITY PROBLEMS
anxious, confusion, agitation, loss of
consciousness
EXPOSURE PROBLEMS
urticaria, angioedem

TREATMENT
RECOGNITION Call HELP Initial
assessment ABCDE approach
ADRENALINE Follow-up
Pts positioning
Low BP flat with or without leg elevation
A-B problems sit up
Unconscious recovery position
Pregnant pt LLD to prevent caval
compression
REMOVE the trigger if possible


DRUGS for ANAPHYLAXIS
1. ADRENALINE
2. OXYGEN
3. FLUIDS
4. ANTIHISTAMINE
5. CORTICOSTEROID
6. OTHER DRUGS
REFERENCES
Emergency medical treatment of anaphylactic
reactions. Project Team of The Resuscitation Council
(UK). Resuscitation 1999;41(2):93-9

You might also like