Sidra Yousaf, RN
Objectives
By the end of this presentation the participants will be able to:
Know goals of sedation.
Recognize characteristics of good sedation.
Define Agitation.
Understand sedatives pharmacology.
Explain Richmond Agitation-Sedation Scale
Goals of sedation in the ICU
Patient comfort
Control of pain
Anxiolysis and amnesia
Adverse autonomic and hemodynamic responses
Facilitate nursing management
Facilitate mechanical ventilation
Avoid self extubation
Reduce oxygen consumption
Characteristics of an ideal sedation agents for the
ICU
Lack of respiratory depression
Analgesia, especially for surgical patient
Sedation with ease of orientation and arousability
Anxiolytic
Hemodynamic stability
The Challenges of ICU Sedation
Altered pharmacology
Tolerance
Delayed emergence
Withdrawal
Drug interaction
What is AGITATION
A syndrome of excessive motor activity, usually non-
purposeful and associated with internal tension.
1.Violent motion.
Causes of Agitation
Pain
Anxiety
Fear
Withdrawal
Depression
Patient-Ventilator interactions
Sleep Deprivation
Sedation in ICU
Continuous or Analgesia ?
Intermittent ?
Anxiolytic ?
Analgesia
Morphine Fentanyl
Hydromorphone +Short acting
+BP neutral
Fentanyl Morphine
+Air hunger
Hydromorphone
+Good for opioid
tolerant patient
Anxiolytic
Propofol
+Short acting
_Hypotension
Benzodiazepines _Bradycardia
Propofol _Hyperlipidemia
Benzo’s
+ Alcoholic withdrawal
+BP neutral
_Delirium
Haloperidol
Haloperidol
+Short acting
+BP neutral
+Delirium
_QT prolongation
It depends on the patients!
Target RASS +4 to -5
Richmond Agitation-Sedation Scale
Richmond Agitation-Sedation Scale is a medical scale used to
measure the agitation or sedation level of a patient. The RASS
can be used in all hospitalized patients to describe their level
of alertness or agitation. mostly used in mechanically
ventilated patients in order to avoid over and under-sedation.