Praktikum Px Sensoris
dr. Nisa Karima, M.Sc.
Sensory Pathway
Stimulus
Sensory receptor (= transducer)
Afferent sensory neurons
CNS
Integration, perception
Sensory system
Receptors:
- specialised (smell, vision, hearing, taste
- visceral (viscera, smooth muscle -unconscious or autonomic)
- somatic (skin, striated muscle, joints)
Cutaneous
receptors
Muscle, tendon
receptors
Touch Receptors
Free or encapsulated dendritic endings
In skin and deep organs, e.g.: Pacinian
corpuscles
concentric layers of c.t. large receptive field
detect vibration
opens mechanically
gated ion channel
rapid adaptation
receptor type?
• Electrical, mechanical, chemical stimuli (touch, pressure,
temperature, and pain):
• Dorsal column – Medial lemniscal system large
myelinated fibres discriminative/ fine touch,
proprioception, vibration
• Anterolateral system small myelinated fibres
• Ventral & lateral spinothalamic tracts non-
discriminative touch, pain, cold, warm
Afferent neuron thalamus somatosensory cortex
• Dorsal column – Medial lemniscal system
• Sensory receptor gracile/ cuneate nuclei thalamus
somatosensory cortex
• Anterolateral system
• Sensory receptor spinal cord thalamus
somatosensory cortex
Dorsal Column – Medial Lemniscal System:
1. Touch sensations high degree of localization of the
stimulus
2. Touch sensations transmission of fine gradations of
intensity
3. Phasic sensations (e.g. vibratory sensations)
4. Sensations signaling movement against the skin
5. Position sensations (joints)
6. Pressure sensations fine degrees of judgment of
pressure intensity
Anterolateral System:
1. Pain
2. Thermal sensations (warmth & cold)
3. Crude touch & pressure crude localizing ability on the
surface of the body
4. Tickle & itch
5. Sexual sensations
• Spatial orientation of the nerve fibres in the thalamus (head
in medial side) & SI (head in the lateral side)
• Somatosensory cortex:
• Somatic sensory area I (SI) Postcentral gyrus
high degree of localization
• Somatic sensory area II (SII) Superior wall of Sylvian
fissure poor localization
• The area in SI cortex for each part of the body the
number of receptors in that part of the body
• The effects of cortical lesion:
• Ablation of SI affects sensory processing of SII
SII does not affect SI
• Cortical lesion affects (in order):
1. Proprioception & fine touch affected the most
2. Temperature
3. Pain affected the least perceived by
brainstem reticular formation, thalamus, other lower
brain centers
“The physical adjunct of an imperative protective
reflex” (Sherrington)
Bilateral excision of somatosensory area causes:
1. Unable to localize discretely different sensations in
different parts of body. He/ she can localize crudely
2. Unable to judge critical degrees of pressure against body
3. Unable to judge the weights of objects
4. Unable to judge shapes/ forms of objects (astereognosis)
5. Unable to judge texture of materials
Pain & temperature sensations are intact (quality & intensity),
but poorly localized