By.
Ms Simranpreet kaur
M.Sc (N)
BENIGN PROSTRATIC HYPERPLASIA
DEFINITION
It is the enlargement of the prostate gland resulting
from an increase in the number of epithelial cells
and prostate tissue
CAUSES
Family history particularly involving first degree relatives,
environment history like exposure to environmental
allergens and diet history like consumption of increased
saturated fatty acids like butter, beef.
Age over 80 years associated with endocrine changes.
Increased alcohol intake
Obesity
Excessive accumulation of dihydroxytestosterone
hormone
PATHOPHYSIOLOGY
Due to endocrine changes in ageing
Stimulation of estrogen and local growth hormone
Increased production of 5-α reductase
Conversion of testosterone to dihydroxytestosterone
Excessive accumulation of dihydroxytestosterone
Enlargement of prostate tissue
Compression of the urethra
Obstruction of urinary outflow
Hydroureter & hydronephrosis
CLINICAL MANIFESTATIONS
Obstructive symptoms:
decrease in the force of urinary stream
difficulty in initiating voiding
intermittency (stopping and starting stream many times
while voiding)
dribbling at the end of urination
Irritative symptoms:
urinary frequency, urgency, dysuria
bladder pain, nocturia & incontinence.
DIAGNOSTIC FINDINGS
Digital rectal examination to evaluate the size, symmetry and
consistency of prostate gland.
Urine analysis to determine the presence of infection.
Prostate specific antigen test to rule out prostate cancer
Trans rectal ultrasound to detect the prostate size
Uroflowmetry to study the volume of urine expelled from the
bladder per second help in determining the extent of uretheral
blockage.
Post voidal residual urine volume to determine the degree of urine
outflow obstruction
Cystourethroscopy to allow visualisation of the urethra and bladder.
MANAGEMENT
Dietary modifications like decrease caeffine, artificial sweeteners, spicy
and alcoholic foods.
Avoid medications like decongesants and anticholinergics and restrict
evening fluid intake to reduce irritative symptoms.
Drug therapy :
5 α reductase inhibitors like finasteride & dutasteride to block the
conversion of testosterone to di-hydroxy testosterone.
α- adrenergic receptor blockers like alfuzosin, doxazosin, terazosin to
promote the smooth muscle relaxation in the prostate and facilitate
urinary outflow through the urethra.
herbal therapy like saw palmetto for management of urinary symptoms.
SURGICAL MANAGEMENT
Trans urethral resection of prostate(TURP):
This involves removal of prostate tissue using resectoscope inserted
through the urethra.
Trans urethral incision of prostate (TUIP): this involves making
transurethral slits or incisions in to the prostate tissue to relieve
obstruction.
Trans urethral microwave thermotherapy:
this involves a use of microwave radiating heat to produce
coagulative necrosis to the prostate.
Trans urethral needle ablation (TUNA): this uses a low wave
radiofrequency to heat the prostate causing necrosis.
CONTD…..
Open Prostatectomy: this is the surgery of choice
for men with large prostates which involves the
surgical excision of the prostate tissue.
Laser Prostatectomy: this procedure uses a laser
beam to cut or destroy the part of the prostate.
The destroyed prostate tissue gradually sloughs in
the urinary stream.
NURSING MANAGEMENT
Urinary drainage must be established with the catheter
before surgery
Bladder irrigation is done either intermittently or
continuously to remove clotted blood from the bladder.
Careful aseptic technique should be used when irrigating
the bladder to prevent possible infections
Activities that increase abdominal pressure like sitting or
standing for long periods and straining during defecation
should be avoided.