PROPHASE AND
METAPHASE
( STAGE OF MITOSIS )
PROPHASE
• Prophase is the first stage of cell division in both mitosis
and meiosis. Beginning after interphase, DNA has already
been replicated when the cell enters prophase. The main
occurrences in prophase are the condensation of the
chromatin and the disappearance of the nucleolus.
PROPHASE
• Prophase. The first and longest phase of mitosis is
prophase. During prophase, chromatin condenses into
chromosomes, and the nuclear envelope (the membrane
surrounding the nucleus) breaks down. In animal cells,
the centrioles near the nucleus begin to separate and
move to opposite poles of the cell.
PROPHASE
METAPHASE
• Metaphase is a stage of mitosis in the eukaryotic cell cycle
in which chromosomes are at their second-most condensed
and coiled stage. These chromosomes, carrying genetic
information, align in the equator of the cell before being
separated into each of the two daughter cells.
METAPHASE
• Cells in metaphase are used in medical research to
measure whether all of the chromosomes are present and
whether or not they are all intact. This process of looking
at chromosomes under the microscope is called
karyotyping.
METAPHASE