INSTITUITIONAL REVIEW BOARD

Presenter
Abdul Muneeb
Student BS MLT 7th Semester
Armed Forces Institute of Transfusion, NUMS
Supervisor
Col Rehan Ahmad Khan Lodhi
MBBS, FCPS
Armed Forces Institute of Transfusion
 Topic of Research

Exploring the Impact of Donor Characteristics on Platelet Count in Single

Donor Platelet (SDP) Collection Through Aphaeresis: A Single Center Study
 INTRODUCTION
• Platelet Transfusion: Essential for thrombocytopenic patients undergoing
chemotherapy or major surgeries.

• Single Donor Platelets (SDP): Preferred due to higher yield and lower risk of
infections compared to random donor platelets.

• Problem Statement: Despite technological advancements in apheresis, variability

in platelet yield among donors remains a challenge.

• Aim: Investigate donor characteristics influencing SDP yield to optimize donor

selection and apheresis protocols.
 RESEARCH OBJECTIVE

• Identify donor factors influencing platelet yield

in SDP collection.

• Optimize donor selection criteria for efficient

plateletpheresis.
 LITERATURE REVIEW

•Global Studies:
Found pre-donation platelet count as a key predictor of SDP yield; contradictory
findings on age and blood group influences.

•Technological Advances:
Improved apheresis techniques, but donor-related variability persists.

•Research Gap:
Limited data on the impact of donor characteristics in the Pakistani population.
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RESULTS-DESCRIPTIVE STATISTICS

Donor Characteristics:
• Mean age: 29.0 ± 6.84 years
• Mean weight: 75.8 ± 7.32 kg
• Ethnicity: 95.96% Punjabi

Pre-Donation Parameters:
• Mean platelet count: 254.13 ± 51.004 x 10⁹/L
• MPV: 10.5 (±1.3) fL
 KEYS FINDINGS

Significant Findings:
• Pre-donation platelet count: Positive correlation with SDP yield
(β = 0.230, p = 0.017)
• MPV: Negative correlation with SDP yield (β = -0.230, p = 0.017)

No Correlation:
• Age (p = 0.138), weight (p = 0.064), blood group (p = 0.716)
 DISCUSSION

• Pre-Donation Platelet Count:

Consistent with global studies (Srivastava et al., 2023; Chatterjee et al., 2021)
MPV: Larger platelets → lower yield (Chopra et al., 2023)

• Blood Group & Demographics: No impact aligns with Saini et al. (2024)
 CONCLUSION

Key Findings:
• Pre-donation platelet count and MPV are significant predictors of SDP yield.
• Demographic factors (age, weight, and blood group) show minimal impact.

Significance:
• Recommendations can improve platelet collection efficiency and donor
management in transfusion centers.
 STUDY-LIMITATIONS
• Single-center study
• Limited to male donors

Future Research Recommendations:

• Expand to multiple centers
• Include female and diverse donor populations
• Explore additional hematological factors impacting SDP yield
 Acknowledgments

• Supervisors: Col Rehan Ahmed, Lt Col Sadia Ali, and Saba khursheed
• Sample Collection: Major Saima, Mohsin, Sirkhan
• Colleague: Zain-Ul-Abdeen
 REFERENCES

• Srivastava, A., Yadav, B. K., Das, I., Katharia, R., Chaudhary, R. K., Rani, P., &
Priyadarshi, A. (2023). Effect of donor parameters and cell separators on the yield
of apheresis platelets and their impact on corrected count increment in aplastic
anemia patients. Asian Journal of Transfusion Science, 17, 246-250.

• Chopra, S., Kaur, P., Bedi, R. K., & Kaur, G. (2023). Effect of double-dose
plateletpheresis on target yield and donor platelet recovery. Hematology,
Transfusion and Cell Therapy, 45, 16-24.
THANK YOU