This document discusses applying Lean and Six Sigma principles to improve processes in IT organizations. It provides an introduction to Lean and Six Sigma approaches and how they can be combined ("Lean Six Sigma") to reduce waste and improve quality in IT processes. A case study is presented on applying Six Sigma methods to analyze data from an IT service desk ticketing system to identify factors contributing to SLA breaches. Process improvements were implemented and resulted in significantly reduced handling times and cost savings of over 250k Euro per year.