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clinical trials clinical research principal investigator pharmaceutical companies clinical studies study coordinator sponsor research pfizer trial coordinator cro sponsor studies eli lilly healthcare quintiles merck new drug study abbvie icon plc inc research pharma clinical research site clinical research studies research site help trialjoin biopharma patient recruitment patient retention site coordinator contract research organizations online patient recruitment site management organizations pharmaceutical clinical research regulations cra study brokering consent forms study acquisitions roche novartis crc clinical online presence clinical trial management system monitoring visits site management monitoring plan monitoring study investigators investigator responsibilities ctms investigator obligations budget edc metrics profit review nda patient safety recruitment regulations compliance site finances resources technology case study study related care stand of care clinical clinical project manager regulatory guide help medicine electronic data capture audit business cash flow study designs types of studies safety drug accountability phase 1 phase 1 clinical trials financial allergan systems financial activities data shire motivation database medical