HUMAN BODYCIRCULATORY SYSTEM
COMPOSITION OF BLOODRED CELLSWHITE CELLSPLATELETSfloating in a liquidcalled                           PLASMA
COMPOSITION OF BLOOD
COMPOSITION OF BLOOD
RED BLOOD CELLSBiconcave discsNo nucleiSpongycytoplasmenclosed in anelasticcellmembraneRed pigmentcalledhaemoglobinAre madebythe red bonemarrow of certainbones in theskeleton: ribs, vertebrae and breastbone
Red bloodcells: hystology
Red bonemarrow
HAEMOGLOBIN
Haemoglobin (Hb)Hb   +    O₂                   oxyhaemoglobin (OHb)In places wherethe O₂ concentrationislow, OHbbreaksdown and releasesitsO₂.  Where??Oxygenatedblood : containsmainlyOHb.Deoxygenatedblood : withlittleOHb.
Oxyhaemoglobin
Red bloodcellsAfter 4 monthsHbIronBilirubinStored in theliverBile
WHITE CELLSDifferenttypesLargerthan red cellsTheyhavenucleiThey are made in thesamebonemarrowthat red cellsThetwo more numeroustypes are:             - Phagocytes             - Lymphocytes
White bloodcells
White bloodcells
White bloodcells: PhagocytesTheycollect at thesite of aninfection, engulfing (ingesting) and digestingharmful bacteria. Theypreventthe spread of infectionthroughthebody.
Phagocytes
White bloodcells: LymphocytesProduction of antibodies (proteins)
PLATELETSTheyhelptoclottheblood
PLASMAIons: sodium, potassium, calcium, chloride, hydrogen carbonate.Proteins: fibrinogen (clotting), albuminand globulins (antibodies).Foodsubstances: aa, glucoseand fats.HormonesUrea
Powerpoint circulatory system
Functions of thebloodHomeostaticfunctionsTransportDefenceagainstinfections                 - Clotting                 - White cells
Functions of blood: Transport
THE HEART
HumanHeart4 chambers:                         -  2 atria (thin-walled)                         -  2 ventricles (thick- walled)Veins: deoxygenatedbloodexceptpulmonaryveinArteries: OxygenatedbloodexceptpulmonaryarteryValves: They stop bloodflowingbackwards. Coronaryarteries: Theysupplytheheartmusclewithfood and oxygen.
Humanheart
Valves of the heart
CONTROL OF THE HEART BEATAt rest: normal heartrate, 50-100 beats per minutes.Duringexercise: 200 beats/minTheheart beat isinitiatedbythepacemaker, a smallgroup of specializedmusclescells at the top of therightatrium.
Control of theheart beatBloodpressure↑                                ↓ heartrateBloodpressure↓                                ↑ heartrate↓ O₂ concentration↑ CO₂ concentrationHormone adrenaline
THE CIRCULATION
CIRCULATION
BLOOD VESSELS
Bloodvessels
Arteries, veins: hystology
LYMPHATIC SYSTEM
LymphaticsystemThin-walledvesselscalledlymphatics.Theyemptytheircontentsintothebloodsystem.The fluid iscalledlymph.Most of thelymphflowresultsfromthevesselsbeingcompressedwhenthebodymusclescontract in movementssuch as walkingorbreathing.There are valves, whichforcethe fluid in onedirection: towardstheheart.Lymphnodes: storage of lymphocytes. There are alsophagocytes. Lymphaticorgans:Spleenandthymus
Lymphnodes: part of thebodydefencesystem
Lymphaticorgans: spleen and thymus
SPLEEN: functionsRemoveworn-out red cells, bacteria and cellfragmentsfromtheblood.Produce lymphocytes and antibodies.
THYMUS: functionsParticularlyimportantlymphoidorgan in thenewborn:                  - controlsthedevelopment of thespleen and thelymphnodes.                 - produces lymphocytes (immunity)Afterpuberty, importantimmunologicalorgan, althoughitbecomessmaller.              - storage of whitecells              - production of a largepopulation of lymphocytes T.
Bloodfunctions: DEFENCE AGAINST INFECTIONSWHITE CELLS:             - Phagocytes: - at thesites of a wound                                                - in thebloodcapillaries                                                - in lymphnodesingestharmful bacteria and stop thementeringthe                               general circulation              - Lymphocytes:Production of antibodiesCLOTTING
CLOTTINGWhentissueisdamaged and bloodvesselscutPlateletsclumptogether and block thesmallercapillaries.Fibrinogenfibrin(network of fibresacrossthewound)Red cellsbecometrapped in thisnetwork and form a bloodclot.↓              entry of harmful bacteriapreventsfurtherloss of blood
Clotting
Bloodclotting
ATHEROMA and THROMBOSIS
CORONARY HEART DISEASES
Possible causes of coronaryheartdiseasesSMOKINGFATTY DIETSTRESSLACK OF EXERCISE

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