Downloaded 179 times
Uploaded byNoman-Hafeez khosa
polyoma virus
This document summarizes information about PolyomaVirus. It notes that PolyomaVirus has a non-enveloped, naked icosahedral capsid around 45nm in diameter that contains a closed circular double-stranded DNA genome. It encodes for viral capsid proteins VP1, VP2, and VP3. Examples given are JC virus which can cause progressive multifocal leukoencephalopathy in immunocompromised individuals, and BK virus which can cause renal disease in transplant patients. Transmission is via respiratory fluids or urine and infection may be asymptomatic or cause fever, with diagnosis via PCR or blood/urine tests. There is no effective treatment without toxicity, only supportive care or immunosuppress
More Related Content
![[Micro] parvovirus](https://cdn.slidesharecdn.com/ss_thumbnails/9efvufm6tsedx9o58t7q-signature-2127a2ca5368c7fdfd023e8d90dde3fc0b9fe7d91346a4189562c9f63dc0d19d-poli-150819190755-lva1-app6891-thumbnail.jpg?width=640&height=640&fit=bounds)
More from Noman-Hafeez khosa
![MUSHROOM_PRODUCTION_UNITS and mechanism 1][1].pptx](https://cdn.slidesharecdn.com/ss_thumbnails/mushroomproductionunits11-251106185651-32f95ca8-thumbnail.jpg?width=640&height=640&fit=bounds)
polyoma virus
- 1. Represented by: Kainat Zafar 13-131-02 ErumHaider 13-131-03
- 2.
- 3. PolyomaVirus Poly= multiple& oma= tumor Family: Polyomaviridae (formally grouped with papillomaviruses) Non-Enveloped, Naked Capsid. Icosahedral shape. Capsid: about 45nm in diameter
- 4. PolyomaVirus Closed, Circular,dsDNA genome Complexed with cellular histones. Encodes proteins/genes: VP1(Viral protein 1), VP2, VP3---form viral capsid Polyomavirus replicates in nucleus of host, host dependent-specific
- 5. PolyomaVirus Examples: 1-JC virus (JCV) Causes progressive multifocal leukoencephalopathy (PML) Progressive demage or inflamation of white matter of brain at multiple locations. Harmless except in cases of weakend immune system in AIDS 2-BK virus (BKV) Latent until immunosuppression occurs. Causes renal diseases in kidney transplanted patients
- 6. PolyomaVirus Virus Symptoms & Transmission Infection/ Disease DiagnosisTreatment BK Transmission: Respiratory fluid or urine Renal disease in AIDS paients Respiratory infection Fever PCR Blood or urine test No effective drugs without toxicity. Supportive JC Transmission: Respiratory Infect respiratory system, kidneys or brain PML (progressive leukoencephalopathy) in AIDS & transplant patients. As given above Supportive Potent imunosuppere nt drugs
- 7. Reference http//.www.polyomaviridaewiki.com FromMedical Microbiology http://www.google.com KAPLAN Medical USMLE Step 1.Immunology & Microbiology.