This systematic review examines the relationship between social media use and depressive symptoms in children and adolescents. Eleven studies with a total sample of 12,646 young people were included. The analysis found a small but statistically significant correlation between greater social media use and higher rates of depressive symptoms. However, the studies varied widely in methods, sample sizes, and results, so the clinical significance of this relationship remains unclear. Over half the studies were cross-sectional, and longitudinal studies were of limited duration. Further research is needed using consistent variables and measurements.