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AMINO ACIDS DEG-WPS Office.pptx
- 1. AMINO ACIDS DEGRADATION ANDSYNTHESIS Dr.Hala Hamaish
- 2. Glucogenic and ketogenicAmino acids Glucogenic amino acids • Whose catabolism can yield pyrovate or intermediate products of TCA cycle that are used as substrate for gluconeogenesis. Ketogenic amino acids • A.A that produce acetoacetate.
- 3. Amino Acids thatform Oxaloacetate (OAA) • Asparagine • Significance
- 5. Amino Acids thatform Alpha ketoglutarate 1) Glutamine • In the presence of GLUTAMINASE the Aminoacids is converted into glutamate ,that is further converted into alpha ketoglutarate by oxidative deamination in the presence of glutamate dehydrogenase(GDH). • AMONIA is liberated from the reaction.
- 6. Cont... 2) Proline • A.Ais oxidised to glutamate that further forms Alpha Ketoglutarate. 3) Arginine • AA is hydrolyzed by ARGINASE to produce ornithine. • Ornithine is further converted into alpha Ketoglutarate.
- 7. Cont... 4) Histidine • A.Ain the presence of HISTIDASE is converted into uroconic acid, that subsequently forms N- Formiminoglutamate(FIGlu). • In the presence of folic acid (THF) converted into formimino tetrahydrofolate and glutamate.that ultimately converted to alpha ketoglutarate. • Significance
- 8. Amino Acid thatform pyrovate • Alanine • Serine • Glycine • Cysteine • Threonine
- 11. Cont... 3) Cysteine • A.Aundergoes desulfuration to produce pyrovate • Sulfer released can be used to synthesize PAPS , 3- phosphoadenosine-5-phosphosulfate, an activated Sulfer sonar. • Cysteine can be oxidised to cystine. 4)Threonine • Can be converted to pyrovate but it is of minor importance
- 12. Amino Acids thatform fumarate • Phenylalanine and tyrosine • Significance
- 14. Amino Acids thatforms succinyle co.A • Methionine . • Valine and isoleucine • Threonine
- 18. Cont... • Valine andisoleucine • These A.A are Branched chain Aminoacids,that generate propionyle Co.A • which is converted to methylemalonyle co.A and then succinyle co.A by biotin and vit B 12 . • Threonine • These are first dehydrated to alpha ketobutyrate, which is converted to succinyle co.A
- 19. Amino acids thatforms Acetyle COA 1) Leucine • Exclusively ketogenic ,it produces acetyle coA and acetoacetate. • 2)Lysine • Exclusively ketogenic • No transamination
- 20. Cont... 3)Isoleucine • Both ketogenicand glucogenic • Produces acetyle CoA and propionyle CoA. 4)Tryptophan • Both glucogenic and ketogenic • Catabolised to produce alanine and acetyle CoA.
- 21. Catabolism of branchedchain Amino Acids
- 24.