AMR Collaborative Grants at the University of Bristol
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The document discusses various topics relating to antibiotic resistance (AMR) transmission in real world settings. It mentions that dairy farming uses cephalosporins extensively and explores potential links between this usage and cephalosporin resistant E. coli infections in humans. The document also discusses using proteomics to identify mechanisms of antibiotic resistance and finding new antibiotic lead compounds through comparative studies.
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AMR Collaborative Grants at the University of Bristol
- 1. Dr Matthew B. Avison, Senior Lecturer in Microbiology School of Cellular & Molecular Medicine AMR Collaborative Grants at the University of Bristol
- 2. AMR transmission in the real world. • Dairy Farming uses a lot of cephalosporins. • Is there a link with AMR and can it be reversed? • Do dogs and people pick up E. coli from the environment? • Is there a link to UTIs caused by Cephalosporin Resistant E. coli in humans? • And can this be reversed? 2 Theme 3
- 3. AMR transmission in the real world. 3 Theme 3
- 4. 4
- 5. 5 Driving Down Antibiotic Usage on Farms.
- 6. Proteomics to Identify AMR. 6 Theme 2
- 7. 7 •Comparative proteomics to identify putative mechanisms of resistance. E.g. coming out of pK/pD models. •Knockouts/over-expression studies to confirm involvement in AMR and relative importance. •Surveys of clinical isolates to identify if novel AMR mechanism is present; how different mechanisms work together. •Impact includes development of strain collections. Identifying AMR Mechanisms.
- 8. 8 Finding New Antibiotic Lead Compounds Theme 2