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Anemia and drug use for the treatment of Anemia
- 1. DRUGS USE TOTREAT ANEMIA Prepared by:Dr Touseef (BUMDC)
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- 5. Usual Criteria of Hbin ANEMIA >11.5G/dl in women >14G/dl in men
- 7. Signs and Symptoms: Patientswith a Hb less than 7G/dl will have appear following symptoms ; Tissue hypoxia Fatigue Headache Dyspnea Pallor Angina Tachycardia Visual impairment Syncope Lymphadenopathy Hepatic and or splenic enlargement Bone tenderness Blood loss in feces Neurologic symptoms.
- 8. Classification of anemia: 1.Anemia associated with decrease RBC production Iron deficiency anemia, Megaloblastic anemia Thalassemia Anemia due to chronic disease and renal failure. 2. Anemia due to increased RBC destruction: Haemolytic anemia sickle cell anemia
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- 11. CAUSES OF IRONDEFECIENCY ANEMIA
- 12. Treatment of irondeficiency Anemia
- 18. Indication for theuse of iron
- 19. Iron Toxicity Deferasirox –an oraliron chelator approved for treatment of iron overload
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- 21. Pharmacokinetics: • Source: Meat(liver), eggs, & dairy products. • coblamine is absorbed from the GIT in the presence of intrinsic factor, a product of the parietal cells of the stomach. • Plasma transport is accomplished by binding to transcobalamin II. • Coblamine is stored in the liver in large amounts; a normal individual has enough to last 5 years. It is available in 2 forms 1. cyanocobalamine 2. hydroxy cobalamine has a longer circulating half life.
- 23. •Deficiency leads to anemia, gastrointestinal symptoms, andneurologicabnormalities. •Deoxyadenosyl cobalamin •methylcobalamin •Cyanocobalamin •hydroxocobalamin •Source of vitamin BI2 • meat (especially liver), eggs, and dairyproducts. •Vitamin B12 is sometimes called extrinsic factor active forms of the vitamin in humans found in food sources are converted to the active forms
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- 25. 25 Uses: 1- Pernicious Anemia: (defective secretion of intrinsic factor by the gastric mucosal cells) 2- Neurologic abnormalities: 3- Gastrectomy 4- Cyanide poisoning.
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- 27. Why folic acidgive with vitB12
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