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Antibiotics
This document discusses several key principles of antibiotics: they are designed to selectively target bacteria while minimizing harm to human cells. It provides examples of classes of antibiotics including penicillins, cephalosporins, carbapenems, glycopeptides, aminoglycosides and others. Ideal properties of antibiotics and challenges like emerging resistance are covered. Common infections and appropriate antibiotic choices are outlined. Factors to consider when prescribing antibiotics are also mentioned.
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Antibiotics
- 1.
- 2. SOME GENERAL PRINCIPLES •Antibiotics can be naturally produced, semi-synthetic, or synthetic substances • Designed to have as much selective toxicity on the bacteria as possible • This is more likely to be achieved compared to antimicrobials acting against eukaryotic cells (fungi, protozoa)
- 3. EXAMPLES OF SELECTIVE ACTION •Penicillin on bacterial cell wall (organisms without cell wall won’t be inhibited eg Mycoplasma pneumoniae) • Sulphonamides prevent bacteria synthesising folic acid whereas humans can use preformed folate • Generally drugs acting on cell membranes or protein synthesis are more toxic to humans
- 4. ANTIBIOTICS ACTING ONCELL WALL OF BACTERIA • Beta lactams: • Penicillins, cephalosporins, carbapenems, monobactam • Glycopeptides: • Vancomycin, teicoplanin
- 5. THE IDEAL ANTIBIOTIC?:PENICILLIN • Narrowspectrum • Bactericidal • Very selective mode of action • Low serum protein binding • Widely distributed in body esp. CNS • Excreted by the kidneys
- 6. THE DEVELOPMENT OFTHE BETA LACTAMS • Benzylenicillin and early cephalosporins mainly active against gram positive bacteria (strep and staph) • Then “broad spectrum” penicillins appeared: ampicillin, ureidopenicillins and cephalosporins: cefuroxime, cefotaxime • Carbapenems and latest generation of cephalosporins, eg ceftazidime more active against gram negatives
- 7. BENZYLPENICILLIN: MAIN INDICATIONS Streppyogenes sepsis (from sore throat to fasciitis) Pneumococcal pneumonia, meningitis Meningococcal meningitis, sepsis Infective endocarditis (strep) Strep group B sepsis Diphtheria Syphilis, leptospirosis
- 8. Broader spectrum penicillins •Ampicillin, amoxycillin cover most organisms hit by penicillin but also Esch coli, some Proteus (cause UTI’s) • Augmentin stable to TEM1 beta lactamase because of the clavulanic acid therefore more active than ampicillin • Tazocin: broader coverage than augmentin against gram negatives including Pseudomonas
- 9. Organisms producing TEM1beta lactamase •Haemophilus influenzae • Neisseria gonorrhoeae • Bacteroides fragilis • Staph aureus • Esch coli
- 10. Carbapenems • Imipenem, meropenem:have a very broad spectrum activity against gram-negative bacteria, anaerobes, streps • Now used to treat gram negative infections due to so called ESBL producing organisms eg, E coli, Klebsiella • Ertapenem is a new member of the group but its not active against Pseudomonas
- 11. PENICILLIN IS GENERALLY VERYSAFE BUT…. • Allergic reactions not uncommon-rashes • Most severe reaction being anaphylaxis • A history of anaphylaxis, urticaria, or rash immediately after penicillin indicates risk of immediate hypersensitivity after a further dose of any penicillin or cephalosporin (therefore these must be avoided) • Allergy is not dependent on the dose given ie, a small dose could cause anaphylaxis • Very high doses of penicillin can cause neurotoxicity • Never give penicillin intrathecally
- 12. What antibiotics canbe used in penicillin allergy? • Macrolides: erythromycin, clarithromycin • (mainly gram positive cover) • Quinolones: ciprofloxacin, levofloxacin (mainly gram positive cover) • Glycopeptides (serious infections) • Fusidic acid, rifampicin, clindamycin (mainly gram positive)
- 13. REMEMBER WHAT THEOTHER BETA LACTAMS ARE: • All penicillins: ampicillin, augmentin, piperacillin, cloxacillin • Cephalosporins: cefuroxime, cefotaxime, ceftriaxone, ceftazidime (5-10% cross sensitivity) • Monobactam: aztreonam (low cross sensitivity) • Carbapenems: imipenem, meropenem
- 14. CLOXACILLIN • Narrow spectrum:Staph aureus (MSSA) • Stable to TEM1 beta lactamase • Similar antibiotics are methicillin, nafcillin • Similar safety profile to benzylpenicillin • MRSA emerged in the early 1970’s (MecA gene encoding additional pbp)
- 15. Cephalosporins: main uses •Cefuroxime: surgical prophylaxis • Cefotaxime/ceftriaxone: meningitis nosocomial infections excluding Pseudomonal, • Ceftazidime: nosocomial infections including Pseudomonal
- 16. Problems with antibioticresistance: how does it happen? • Some bacteria are naturally resistant to particular antibiotics (Pseudomonas has permeability barrier to many antibiotics) • Some typically susceptible species have minority populations which are resistant by virtue of mutational resistance (pneumococcus) • Other species acquire resistance via plasmids (“infectious resistance”) eg Neisseria gonorrhoeae, many gram negatives
- 17. Current major antibioticresistance problems: community infections • Respiratory tract: penicillin resistance in pneumococcus (5-10%) • Gastrointestinal: quinolone resistance in Campylobacter • Sexually transmitted: penicillin, quinolone resistance in gonococcus • Urinary tract: beta lactam resistance in Esch coli • MRSA and MDRTB • Tropical: multidrug resistance in Salmonella typhi, Shigella spp
- 18. Current major resistanceproblems: hospital infections • MRSA: current strains are often multiply- antibiotic resistant • VISA/GISA: intermediate resistance to glycopeptides (thickened cell wall) • VRSA/GRSA: highly resistant (transferable on plasmids) from enterococci • VRE: enterococci (multiply resis tant) • Broad spectrum beta lactam resistant (ESBL) Esch coli, Klebsiella • Multiply antibiotic resistant enterobacteria: Acinetobacter, Stenotrophomonas, Serratia
- 19. Other major antibioticgroups: aminoglycosides • Gentamicin, amikacin (tobramycin, streptomycin) • Mainly active against gram negative bacteria • Mainly used to treat nosocomial infections: pneumonia in ITU, septicaemia • Limiting factors are nephrotoxicity (and ototoxicity) and resistance • Also used in combination
- 20. How we giveaminoglycosides • For serious nosocomial infections: “extended interval” or once daily dosing • 5 or 7mg/kg for gentamicin (Hartford nomogram) • Rationale based on concentration- dependent killing and post-antibiotic effect • Reduced risk of nephrotoxicity • In infective endocarditis use lower doses to give synergy with penicillin
- 21. Some indications andlimitations of particular antibiotics
- 22. Community acquired pneumonia •Pneumococcus (and H influenzae) are most likely: therefore ampicillin, amoxycillin or augmentin • Severe pneumonia: cefotaxime • Severe atypical pneumonia (Legionella): macrolide or quinolone • Resistant pneumococcus: vancomycin or linezolid (new antibiotic!) • A new quinolone moxifloxacin covers most of these pathogens (likely to be used more in community)
- 23. Community acquired urinary infections •Ampicillin, amoxycillin, augmentin • Oral cephalosporin: cephradine • Trimethroprim • Nalidixic acid • Nitrofurantoin • Ciprofloxacin • Mecillinam
- 24. Skin and softtissue infections • Cellulitis ? Streptococcal: penicillin or augmentin • Infected eczema ? Staphylococccal/mixed: penicillin+flucloxacillin or augmentin • Necrotising fasciitis: penicillin+clindamycin • Septic arthritis: fluclox+fusidic acid • Gangrene: metronidazole
- 25. Where there isdeep-seated infection: bone, abscess • Need an antibiotic with good tissue and phagocyte penetration • Examples are rifampicin, clindamycin, fusidic acid, ciprofloxacin, metronidazole • So for treatment of Staph aureus osteomyelitis: flucloxacillin+ fusidic acid
- 26. Why do weuse combination therapy? • When treating serious infection empirically we want to cover a broad spectrum (severe pneumonia:cefotaxime+erythromycin) • To prevent the emergence of drug resistance: tuberculosis regimens • For synergy: infective endocarditis (aminoglycoside) • For mixed infections eg, abdominal sepsis (tazocin+metronidazole)
- 27. Factors to considerwhen prescribing an antibiotic • Any history of allergy, toxicity? • Is it appropriate for the spectrum I want to cover? • What route of admin: oral or i.v? • Any factors affecting absorption ? • Is it going to reach the site of infection? • Any drug interactions? • Any serious toxicity eg, hepatic, renal? • Does it need monitoring eg aminoglycosides, vancomycin, streptomycin?
- 28. Some other antibioticsoccasionally used • Co-trimoxazole (Stenotrophomonas) • Chloramphenicol (typhoid fever, meningitis) • Colistin (resistant Pseudomonas) topical • Neomycin: gut decontamination, topical
- 29. Special situations • Paediatrics •Obesity • Renal failure (haemodialysis/filtration) • Hepatic failure • CNS infections • Epidemiology (contacts of cases