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antiseborrhics keratolytics and melanizing agents
This document summarizes keratolytic, anti-seborrheic, and melanizing agents. It recommends using salicylic acid 10-20%, resorcinol 3-10%, or urea 5-20% as keratolytics. For seborrheic dermatitis, it suggests selenium sulfide 2.5%, zinc pyrithione 1%, corticosteroids, or imidazole antifungals like ketoconazole. To increase pigmentation in vitiligo, it describes using furocoumarins from plants like Ammi majus or synthetic psoralens like methoxsalen and trioxalen, applied topically or taken or
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antiseborrhics keratolytics and melanizing agents
- 5. • Dissolve intercellularsubstance in horny layer of skin • Epidermal cells swell, soften & desquamate
- 6. SALICYLIC ACID 10-20% solin alcohol or propylene glycol for dissolving corns. Polypylene glycol?
- 8.
- 9. UREA 5-20% in cream& ointment base Ichthyosis,lichen planus Concurrently with topical steroid?
- 11. SALICYLIC ACID 10-20% RESORCINOL3-10% UREA 5-20%
- 15. Seborrheic dermatitis-face,trunk, scalp(dandruff) Pityrosporum ovale Emotional ,genetic,local factors
- 17. SELENIUM SULFIDE ZINC PYRITHIONE CORTICOSTEROIDS IMIDAZOLEANTIFUNGALS SULFUR, COAL TAR,AMMONIATED MERCURY RESORCINOL SALICYLIC ACID
- 18. SELENIUM SULFIDE 2.5% lotionor shampoo Antiproliferative,antikeratolytic,fungicid al More than 50% -relapse on discontinuation.
- 19. ZINC PYRITHIONE Weekly shampoo-1% ‘Reduce’epidermal turnover, dandruff With ketoconazole
- 20. CORTICOSTEROIDS Lotion-massage in scalp Relapserates high Atopy ,poor healing, purpura...
- 21. IMIDAZOLE ANTIFUNGALS KETACONAZOLE(KTZ)-200mg/day for4 weeks 2% shampoo/cream/scalp gel Good – excellant results without much S/E
- 22. SELENIUM SULFIDE 2.5% ZINCPYRITHIONE 1% CORTICOSTEROIDS IMIDAZOLE ANTIFUNGALS SULFUR, COAL TAR,AMMONIATED MERCURY RESORCINOL SALICYLIC ACID
- 27. Increase sensitivity tosolar radiation Repigmentation of vitiliginous areas Stimulate melanocytes & induce proliferation
- 29. Ammi majus Furocoumarins –photoactivation stimulate melanocytes & induce proliferation
- 31. METHOXSALEN & TRIOXSALEN Syntheticpsoralens Sensitize skin Topical & oral Short plasma t1/2 ; max skin sensitization 1-2 hrs ;lasts for 8 hrs.
- 32.
- 33. TOPICAL Solution or ointment Onwell defined vitiliginous lesion 1 min exposure to sunlight Occluded by bandage or sunscreen ointment Under supervision of physician.
- 34. ORAL THERAPY “In alternatedays after 2 hrs of 0.3-0.6mg/kg 15 min exposure to sunlight gradually increasing to 30 min.” Normally pigmented areas should be protected
- 36. Keratolytics salicylic acid,resorcinol, urea Anti-seborrheics seleniumsulfide, zinc pyrithione, corticosteroids imidazole antifungals. Melanizing agents- Psoralen, methoxsalen ,trioxalen