ANZUP1 (dragged)

ANZUP1 (dragged)

• 1.
  Aim: The aimof this questionnaire is to assess current practices amongst clinicians treating metastatic renal cell carcinoma in particular their use of stereotactic radiotherapy and the concurrent use of targeted therapies with radiotherapy. This survey also aims to determine the potential level of support for future clinical trials in this area. This study was approved by the Ethics Review Committee of the Sydney Local Health District. The primary objective was to evaluate the proportion of clinicians utilising radiotherapy in treating metastatic renal cell carcinoma. Secondary objec- tives were the proportion of clinicians utilising targeted therapies and radio- therapy simultaneously, proportion of clinicians stopping targeted therapies for radiotherapy, proportion of clinicians happy to support further research in this area and the variation in practice amongst clinicians across Austral- asia and different specialty fields. Methods: An online survey was created using Surveymonkey and distrib- uted to members of Australia and New Zealand Urological and Prostate Cancer Clinical Trials Group (ANZUP), Faculty of Radiation Oncology Genito-Urinary Group (FROGG) and the Urological Society of Australia and New Zealand (USANZ) via email which included an explanation and link to online version of the survey. Descriptive statistics will be performed to analyse the data and presented as proportions, percentages, means or medians. Results and Conclusion: will be presented at ANZUP ASM. abs#117 MANAGEMENT OF PATIENTS WITH NON-METASTATIC MUSCLE INVASIVE BLADDER CANCER. A SURVEY OF CLINICIANS’ PRACTICE A. Long1 , M. Stockler1 , S. Sengupta2 1 NHMRC Clinical Trials Centre, University of Sydney, NSW, 2 Austin Health, Heidelberg, VIC, Australia Background: Bladder cancer is the 7th most common cancer worldwide in men and affects men 4 x more frequently than women. Chemotherapy improves survival when given before or after surgery for muscle-invasive urothelial cancer but the optimal strategy is unknown. Preoperative regi- mens are the best tested, but have modest benefits (hazard rate 0.88), whereas postoperative regimens are less well tested, with smaller sample sizes and heterogeneity in methodology, but seem to have larger benefits (hazard rate 0.77). MVAC, CMV and cisplatin and gemcitabine (CG) are the most widely used regimens while Accelerated MVAC (accMVAC) is the most active regimen. We believe clinical practice in this area is heterog- enous as there is little consensus. It is important to describe current prac- tices amongst clinicians so that future research will address the most pertinent questions. Methods: An online survey was developed and constructed using Survey Monkey. It was initially piloted with a small group of clinicians to test validity and clarity. After refinement and Ethics approval the survey was distributed to Australian and New Zealand medical oncologists, urologists and radiation oncologists who were contacted through their membership groups Australia and New Zealand Urological and Prostate Cancer (ANZUP) Trials Group and Urological Society of Australia and New Zealand (USANZ). All responses were de-identified. Data analyses was conducted with IBM SPSS v 22. Results: N = 45 respondents (32 medical oncologist, 1 radiation oncologist and 12 urologist). 71% practicing in the Metro area while the rest in rural or regional practice. 71% suggested that they would consider “most” of their patients for Peri-operative chemotherapy. 19 respondents preferred Cis / Gem Q3 weekly to other forms of chemotherapy in this patient group with only 5 respondents supporting MVAC and 2 respondents supporting CMV. 100% of surgical respondents carried out lymph node dissections when performing a cystectomy. Conclusions: Clinical practice in this area is diverse and subject to clinician preferences. abs#118 OUTCOMESFROMCYSTECTOMYINPATIENTSOVERTHEAGEOF 80 T. Manning1 , L. Izquerdo2 , N. Lawrentschuk1 , A. Alcaraz, D. Bolton1 , S. Sengupta1 1 Austin Health, Heidelberg, VIC, Australia, 2 Department of Urology, Hospital Clinico, Barcelona, Spain Introduction: Life expectancy in developed countries is continuosuly increasing. That fact justifies why the elderly patients are becoming more common in our clinical practice. Currently, one of the challenges of medicine remains the question wether patients should undergo aggressive treatments given the significant risk that entails. Objective: To describe the results and complications of surgical patients over 80 years undergoing radical cystectomy for bladder tumor. Material and methods: A total of 34 cystectomy in patients older than 80 years have been carried out in the Hospital Clinic of Barcelona (Spain ) during the period between 1991 and 2010. The reason for the radical surgical treat- ment was bladder tumor. A retrospective review of these patients was per- formed by evaluating the clinical and pathologic features and complications. Results: The median age of the series was 82.3 years. Seven of them were women and 27 men. Regarding the ASA classification, 15 patients were ASA II , 15 patients ASA III and 4 ASA IV. Prior to surgery, 16 patients had hydronephrosis. The mean creatinine series was 1.8 ng/dl. In 32 cases ileal conduit was performed, 1 case ureterosigmoidostomy and 1 cutaneous ure- terostomy case. The mean operative time was 210.3 minutes and a total of 20 patients required blood transfusion. The average hospital staying was 10.4 days. Concerning early complications: 9 cases of paralytic ileus, 4 surgical wound infections, 1 lymphocele and 1 urinary fistula. A total of 4 patients required surgical reintervention (2 evisceration, 1 bleeding and 1 case of urinary fistula). Two patients died in the immediate postoperative period. Regarding late complications: 6 cases of sepsis and 1 case of ureteral stenosis. The mean follow-up of the series was 20.3 months (0.03–134.7 months). During this period 22 of the 18 patients died due to the tumor, 2 patients in the immediate postoperative period, 1 case due to heart disease and 1 case of respiratory infection. Conclusion: Radical cystectomy is an aggressive treatment with a non- negligible complication rate. Careful selection of patients is necessary in order to minimize the complications of this surgery. abs#119 BASELINE CHARACTERISTICS OF THE PARTICIPANTS IN A TELEPHONE-DELIVERED MINDFULNESS INTERVENTION FOR MEN WITH ADVANCED PROSTATE CANCER R. McDowall1,2 , S. K. Chambers1,2,3,4 , D. P. Smith2,5 , M. Berry2 , S. Lepore6 , E. Foley7 , S. Clutton1,2 , S. Occhipinti2,8 , M. Frydenberg2,9,10 , R. A. Gardiner2,11,12 1 Cancer Council Queensland, Brisbane, Queensland, Australia, 2 Australian and New Zealand Urogenital and Prostate Cancer Trials Group, Sydney, New South Wales, Australia, 3 Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia, 4 Prostate Cancer Foundation of Australia, Sydney, New South Wales, Australia, 5 Cancer Council NSW, Sydney, New South Wales, Australia, 6 Department of Public Health, Temple University, Philadelphia, Pennsylvania, United States of America, 7 Mind Potential, Sydney, New South Wales, Australia, 8 School of Psychology, Griffith University, Brisbane, Queensland, Australia, 9 Department of Surgery, Monash University, Melbourne, Victoria, Australia, 10 Royal Melbourne Hospital, Melbourne, Victoria, Australia, 11 University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia, 12 Department of Urology, Royal Brisbane and Women’s Hospital, Brisbane , Queensland, Australia Introduction/Objective: There has been limited psychological intervention research conducted that specifically targets men with advanced prostate Poster Abstracts 37 © 2014 The Authors. © 2014 Wiley Publishing Asia Pty LtdAsia-Pac J Clin Oncol 2014; 10(Suppl. 5): 23–46