This document discusses an approach called Application-Aware Acceleration (A3) to improve application performance over wireless networks. It finds that while transport layer protocols improve performance for FTP, they provide little benefit for other applications like CIFS, SMTP, and HTTP due to the applications' behaviors. A3 addresses this by using principles like transaction prediction, prioritized fetching, and redundant transmissions to offset applications' typical problems when used over wireless networks. The document presents the motivation and design of A3, and evaluates its effectiveness through emulations and a proof-of-concept prototype using NetFilter.