This paper discusses the structural design and analysis for fire-induced collapses, outlining key concepts such as high probability-low consequences (HPLC) versus low probability-high consequences (LPHC) events, the systemic nature of fire accidents, and risk management strategies. It emphasizes the need for complex models to simulate structural responses to fires, assesses past structural failures, and presents a case study of a tall building's structural analysis during a fire scenario. The authors propose a blend of deterministic and stochastic approaches to enhance safety and reliability in structural engineering.