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Brugia malayi
Brugia malayi is a parasitic roundworm commonly known as the Malayan filaria. It is transmitted by mosquitoes in tropical freshwater areas, especially in parts of Asia. The microfilariae have a nocturnal periodicity and are ingested by mosquitoes during blood feeding, where they develop into infective L3 larvae. These larvae are then transmitted to other humans during subsequent mosquito bites, developing into adult worms that reside in the lymphatics and blood, causing diseases such as elephantiasis.
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Brugia malayi
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- 2. Brugia Malayi Commonname: Malayan Filaria Geographic Distribution: Tropical; freshwater (but limited in Asia) Habitat: lymphatics and Blood Periodicity: Nocturnal/Sub-periodic( present at all hours but density increases during night or day) IH: Mansoniabonnae(freshwater swamps) and Mansoniauniformis(rice fields); bite outdoors-night biters
- 3. Brugia Malayi InfectiveStage: L3 Larva MOT: Bite from infected mosquito(anopheles, mansonia Aedes) Diagnosis: Giemsa stained smear(collected at night)/ Knotts’s Technique Pathogenesis: Malayan filariasis
- 4. Morphology Microfilariae: • Size:177 to 230 um; smaller than W. bancrofti • Shape/appearance: curved/kink/stiff • Terminal nuclei: Two • 2 columns of confluent nuclei(irregular/overlap) • Sheathed • Nocturnal periodicity • Locomotion: S-shaped motion
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- 6. Morphology Adults • Resemblethose of W. bancrfofti but smaller • Long and slender with a smooth cuticle • Long cephalic space • Ventrally curved tail • Female worms are larger than males Disease: • Elephantiasis(lower extremeties) • Scrotal swelling(but rare)
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