Delivered at Univ Westminster, October 2025. Here I offer practical guidance for early-career professionals in computational and quantitative biosciences—such as bioinformaticians, biostatisticians, and health data scientists—on navigating their first job search and building a sustainable career. This emphasizes strategy over tactics, recognizing that job hunting is a noisy, partly random process influenced by luck, timing, and positioning. The talk urges candidates to take ownership of their choices, avoid self-pity, and focus on maximizing their “luck surface” through experience, visibility, and networking. Key recommendations include: gaining demonstrable, relevant experience (internships, projects, MSc/PhD work); standing out with unique skills or portfolios; treating early jobs as stepping stones; and building a strong professional network and online presence. Practical advice covers crafting concise, results-focused CVs, writing tailored cover letters, applying efficiently, and approaching interviews with confidence and curiosity. Ultimately, success comes from being deliberate, solving real problems, and continuously creating options rather than waiting for a perfect opportunity