Hypertension – Heart Failure
          Presentation
          74 year old female
          Severe hypertension (187/85, MAP 115mmHg)
          Prior renal failure and heart failure
          8wks in ICU

          Treatment
          CRRT and controlled fluid
          GTN 1.5ug/min/kg – vasodilator for HT




www.uscom.com.au                                  The Measure of Life
Hypertension – Heart Failure

           Effect of Vasodilator on SV

                         Frank Starling Curve
                                              126cm3


        SV                                Dilator




                   SV response to preload (filling pressure or LV volumes)


www.uscom.com.au                                    The Measure of Life
Hypertension – Heart Failure
           Hypertension treatments:
           - Offload fluid – diuretics. (SVV)

           - Reduce SV – Ca blockers and B Blockers (SV, CO, CPo, SW, II)

           - Decrease SVR – dilate arteries with ACE inhibitors/GTN (SVR)




           Is the abnormality in the heart or the vessels (CO/SV and SVR)?

           Complex issues of cardiac and renal disease require
           careful circulatory optimization.




www.uscom.com.au                                The Measure of Life
Hypertension – Heart Failure
          Which treatment is right for this patient?

          What is the cause of her hypertension?
          CO/SV?
          SVR?

          What is her fluid status?

          What is her best treatment?
          Fluid – increase/decrease?
          Inotropes – yes or no?
          Vasoactives - yes or no?




www.uscom.com.au                               The Measure of Life
Hypertension – Heart Failure
           USCOM exam




         BP 185/85,
         MAP 115mmHg


           Can you treat this patient without knowing CO and SVR?

www.uscom.com.au                               The Measure of Life
Hypertension – Heart Failure


          Result
          High CO
          Low SVR




          The low SVR is raising the CO and increasing the MAP.
          The vasodilator is actually raising the MAP!
          Should the vasodilators and CRRT be stopped?

www.uscom.com.au                               The Measure of Life
Hypertension – Heart Failure


          Treatment
          The GTN and
          CRRT was
          stopped

          Result
          Increased SVR
          Decreased CO
          MAP 115 to 94


          The vasodilator was actually raising the MAP!



www.uscom.com.au                                 The Measure of Life
Hypertension – Heart Failure
                                       SVR                                         SV
                                                      1479                  126
                        1600                                         140
                        1400                                         120
                        1200                   1007
          Dyne.s.cm-5




                                                                     100           83     79
                        1000            866
                                 697                                  80                         66




                                                             cm3
                         800
                                                                      60
                         600
                         400                                          40
                         200                                          20
                           0                                           0
                               Base    Post   Day2    Norm                 Base   Post   Day2   Norm


                                       MAP                                        CPo
                                115                                         3.2
                        120             102                          3.5
                                               94
                        100                                           3
                                                       82
                                                                     2.5           2.1
                         80
          mmHg




                                                             Watts    2                   1.5
                         60
                                                                     1.5                          1
                         40
                                                                      1
                         20                                          0.5
                          0                                           0
                               Base    Post   Day2    Norm                 Base   Post   Day2   Norm



www.uscom.com.au                                                     The Measure of Life
Hypertension – Heart Failure

          Summary
          Hypertension can be caused by excess fluid, high CO or high SVR.
          Appropriate therapy requires identification of abnormality - need to
          measure CO/SV and SVR.
          Hypertension, heart failure and renal failure are closely related.
          This relationship is complex and complicates fluid and circulatory
          management.

          Conclusion
          Trend measures of objective hemodynamics provide unique insights into
          renal and cardiac disease and may improve cardiovascular therapy




www.uscom.com.au                                 The Measure of Life

Case Study - Adult - Hypertension - Heart Failure

  • 1.
    Hypertension – HeartFailure Presentation 74 year old female Severe hypertension (187/85, MAP 115mmHg) Prior renal failure and heart failure 8wks in ICU Treatment CRRT and controlled fluid GTN 1.5ug/min/kg – vasodilator for HT www.uscom.com.au The Measure of Life
  • 2.
    Hypertension – HeartFailure Effect of Vasodilator on SV Frank Starling Curve 126cm3 SV Dilator SV response to preload (filling pressure or LV volumes) www.uscom.com.au The Measure of Life
  • 3.
    Hypertension – HeartFailure Hypertension treatments: - Offload fluid – diuretics. (SVV) - Reduce SV – Ca blockers and B Blockers (SV, CO, CPo, SW, II) - Decrease SVR – dilate arteries with ACE inhibitors/GTN (SVR) Is the abnormality in the heart or the vessels (CO/SV and SVR)? Complex issues of cardiac and renal disease require careful circulatory optimization. www.uscom.com.au The Measure of Life
  • 4.
    Hypertension – HeartFailure Which treatment is right for this patient? What is the cause of her hypertension? CO/SV? SVR? What is her fluid status? What is her best treatment? Fluid – increase/decrease? Inotropes – yes or no? Vasoactives - yes or no? www.uscom.com.au The Measure of Life
  • 5.
    Hypertension – HeartFailure USCOM exam BP 185/85, MAP 115mmHg Can you treat this patient without knowing CO and SVR? www.uscom.com.au The Measure of Life
  • 6.
    Hypertension – HeartFailure Result High CO Low SVR The low SVR is raising the CO and increasing the MAP. The vasodilator is actually raising the MAP! Should the vasodilators and CRRT be stopped? www.uscom.com.au The Measure of Life
  • 7.
    Hypertension – HeartFailure Treatment The GTN and CRRT was stopped Result Increased SVR Decreased CO MAP 115 to 94 The vasodilator was actually raising the MAP! www.uscom.com.au The Measure of Life
  • 8.
    Hypertension – HeartFailure SVR SV 1479 126 1600 140 1400 120 1200 1007 Dyne.s.cm-5 100 83 79 1000 866 697 80 66 cm3 800 60 600 400 40 200 20 0 0 Base Post Day2 Norm Base Post Day2 Norm MAP CPo 115 3.2 120 102 3.5 94 100 3 82 2.5 2.1 80 mmHg Watts 2 1.5 60 1.5 1 40 1 20 0.5 0 0 Base Post Day2 Norm Base Post Day2 Norm www.uscom.com.au The Measure of Life
  • 9.
    Hypertension – HeartFailure Summary Hypertension can be caused by excess fluid, high CO or high SVR. Appropriate therapy requires identification of abnormality - need to measure CO/SV and SVR. Hypertension, heart failure and renal failure are closely related. This relationship is complex and complicates fluid and circulatory management. Conclusion Trend measures of objective hemodynamics provide unique insights into renal and cardiac disease and may improve cardiovascular therapy www.uscom.com.au The Measure of Life

Editor's Notes

  • #2 How do you treat this patient without knowing CO and SVR?
  • #3 Let’s remind ourselves!
  • #5 Let’s remind ourselves!
  • #7 BSA – 1.49High SV - 126High SVI - 85 (Typical 30-55)Low SVR – 697 (Typical 1000-1800)Low SVRI – 468 (Typical 2000-3400)HighCO – 13 (Typical 2.5-6.0)High CI – 8.7 (Typical 2.4-3.6)
  • #8 BSA – 1.49High SV - 79High SVI – 53 (Typical 30-55)Low SVR – 1007 (Typical 1000-1800)Low SVRI – 676 (Typical 2000-3400)HighCO – 7.3 (Typical 2.5-6.0)High CI – 4.9 (Typical 2.4-3.6)