This chapter discusses multi-tiered systems of support (MTSS) and response to intervention (RTI). MTSS is defined as a continuum of evidence-based practices to rapidly respond to academic and behavioral needs through frequent data-based monitoring. RTI involves monitoring student response to instruction and intervention. Both concepts are important in the RTI model. The general process involves providing effective classroom instruction, monitoring progress, providing interventions for students who aren't responding, and repeating this process until students reach performance goals. Key considerations for MTSS and RTI include ensuring intervention integrity, using evidence-based interventions, assessing consistent student response, setting criteria for response, and frequent progress monitoring.