This chapter discusses leading instruction with new technologies, including meeting NETP Goals 1 and 2 of learning and assessment and ISTE Standard 2 of developing a digital learning culture. It emphasizes using social networking tools, universal design for learning, and formative and summative assessments. The chapter also includes tips for technology leaders and discussion questions about supporting technology integration, professional development, harnessing students' digital skills, enhancing STEM subjects, and ensuring equitable access to technology.