Clinical decision support systems use information technology to reduce errors and improve clinical decision making by providing clinicians with patient data, knowledge resources, and clinical guidance at the point of care through tools such as diagnostic decision trees, drug databases, alerts, and reminders. However, implementing clinical decision support systems poses challenges around usability, workflow integration, and clarifying the relationship between machine recommendations and human clinical judgment.
Introduction to the theme of Clinical Decision Support Systems (CDS) and an outline of topics.
Explores definitions of decisions, the DIKW pyramid model illustrating data to wisdom.
Discusses various clinical decisions made in patient care, management, and public health.
Focuses on decision making processes, human errors, and the impact of technology on these.
Describes the concept of CDS and its significance in enhancing healthcare decisions.
Details the various forms of clinical decision support, including expert systems and reminders.
Illustrates how CDS aids decision making with examples like abnormal lab highlights and clinical guidelines.
Discusses implementation challenges, human factors, ethical issues, and the significance of usability.
Summarizes key insights about clinical decision support, emphasizing the importance of effective design.
Speculates on the future of machines in healthcare, emphasizing roles, benefits, and ethical considerations. Provides references related to CDS, including studies and guidelines important for further reading.
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Outline
âĒ What isa Decision?
âĒ Clinical Decision Making
âĒ Roles of IT in Decision Making
âĒ Clinical Decision Support Systems
â Definitions
â Types & examples
â Architecture
âĒ Issues Related to CDS Implementation
âĒ Summary
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Example: Problem A
âĒPatient A has a blood pressure reading of
170/100 mmHg
âĒ Data: 170/100
âĒ Information: BP of Patient A = 170/100 mmHg
âĒ Knowledge: Patient A has high blood pressure
âĒ Wisdom (or Decision):
â Patient A needs to be investigated for cause of HT
â Patient A needs to be treated with anti-hypertensives
â Patient A needs to be referred to a cardiologist
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Example: Problem B
âĒPatient B is allergic to penicillin. He was recently
prescribed amoxicillin for his sore throat.
âĒ Data: Penicillin, amoxicillin, sore throat
âĒ Information:
â Patient B has penicillin allergy
â Patient B was prescribed amoxicillin for his sore throat
âĒ Knowledge:
â Patient B may have allergic reaction to his prescription
âĒ Wisdom (or Decision):
â Patient B should not take amoxicillin!!!
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Decision & DecisionMaking
âĒ Decision
â âA choice that you make about something
after thinking about it : the result of decidingâ
(Merriam-Webster Dictionary)
âĒ Decision making
â âThe cognitive process resulting in the
selection of a course of action among several
alternative scenarios.â (Wikipedia)
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Patient Care
Image Sources:(Left) Faculty of Medicine Ramathibodi Hospital (Right) /en.wikipedia.org/wiki/File:Newborn_Examination_1967.jpg (Nevit Dilmen)
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Clinical Decisions
âĒ PatientCare
â What patient history to ask?
â What physical examinations to do?
â What investigations to order?
âĒ Lab tests
âĒ Radiologic studies (X-rays, CTs, MRIs, etc.)
âĒ Other special investigations (EKG, etc.)
â What diagnosis (or possible diagnosis) to
make?
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Clinical Decisions
âĒ PatientCare
â What treatment to order/perform?
âĒ Medications
âĒ Surgery/Procedures/Nursing Interventions
âĒ Patient Education/Advice for Self-Care
âĒ Admission
â How should patient be followed-up?
â With good or poor response to treatment, what
to do next?
â With new information, what to do next?
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Clinical Decisions
âĒ Management
âHow to improve quality of care and clinical
operations?
â How to allocate limited budget & resources?
â What strategies should the hospital pursue &
what actions/projects should be done?
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Clinical Decisions
âĒ PublicHealth
â How to improve health of population?
â How to investigate/control/prevent disease
outbreak?
â How to allocate limited budget & resources?
â What areas of the countryâs public health need
attention & what to do with it?
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Image Source: (Left)http://docwhisperer.wordpress.com/2007/05/31/sleepy-heads/
(Right) http://graphics8.nytimes.com/images/2008/12/05/health/chen_600.jpg
To Err is Human 1: Attention
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Image Source: SuthanSrisangkaew, Department of Pathology, Facutly of Medicine Ramathibodi Hospital, Mahidol University
To Err is Human 2: Memory
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To Err isHuman 3: Cognition
âĒ Cognitive Errors - Example: Decoy Pricing
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Ariely (2008)
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0
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# of
People
# of
People
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âĒ Medical Errors
âDrugallergies
âDrug interactions
âĒ Missing Abnormal Lab Findings
âĒ Clinical Practice Guidelines
âĒ Bias in Judgment & Decision-Making
Common Errors in Healthcare
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External Memory
Knowledge Data
LongTerm Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
Clinical Decision Making
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External Memory
Knowledge Data
LongTerm Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
Possible Human Errors
Possibility of
Human Errors
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âĒ Clinical DecisionSupport (CDS) âis a
process for enhancing health-related
decisions and actions with pertinent,
organized clinical knowledge and patient
information to improve health and healthcare
deliveryâ (Including both computer-based &
non-computer-based CDS)
(Osheroff et al., 2012)
What Is A CDS?
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âĒ Computer-based clinicaldecision support
(CDS): âUse of the computer [ICT] to bring
relevant knowledge to bear on the health
care and well being of a patient.â
(Greenes, 2007)
What Is A CDS?
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âĒ The realplace where most of the values
of health IT can be achieved
âĒ There are a variety of forms and nature
of CDS
Clinical Decision Support
Systems (CDS)
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âĒ Pre-defined documents
âOrdersets, personalized âfavoritesâ
âTemplates for clinical notes
âChecklists
âForms
âĒ Can be either computer-based or
paper-based
CDS Examples
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Order Sets
Image Source:http://www.hospitalmedicine.org/ResourceRoomRedesign/CSSSIS/html/06Reliable/SSI/Order.cfm
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âĒ Simple UIdesigned to help clinical
decision making
âAbnormal lab highlights
âGraphs/visualizations for lab results
âFilters & sorting functions
CDS Examples
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External Memory
Knowledge Data
LongTerm Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Abnormal lab
highlights
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External Memory
Knowledge Data
LongTerm Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Order Sets
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External Memory
Knowledge Data
LongTerm Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Drug-Allergy
Checks
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External Memory
Knowledge Data
LongTerm Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Drug-Drug
Interaction
Checks
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External Memory
Knowledge Data
LongTerm Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Drug-Drug
Interaction
Checks
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External Memory
Knowledge Data
LongTerm Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Clinical Practice
Guideline
Alerts/Reminders
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External Memory
Knowledge Data
LongTerm Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Integration of
Evidence-Based
Resources (e.g.
drug databases,
literature)
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External Memory
Knowledge Data
LongTerm Memory
Knowledge Data
Inference
DECISION
PATIENT
Perception
Attention
Working
Memory
CLINICIAN
Elson, Faughnan & Connelly (1997)
How CDS Supports
Decision Making
Diagnostic/Treatment
Expert Systems
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User User Interface
Patient
Data
InferenceEngine
Knowledge
BaseOther Data
âĒ Rules & Parameters
âĒ Statistical data
âĒ Literature
âĒ Etc.
âĒ System states
âĒ Epidemiological/
surveillance data
âĒ Etc.
Example of CDS
Architecture
Other
Systems
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âĒ How willCDS be implemented in real life?
âĒ Will it interfere with user workflow?
âĒ Will it be used by users? If not, why?
âĒ What user interface design is best?
âĒ What are most common user complaints?
âĒ Who is responsible if something bad
happens?
âĒ How to balance reliance on machines &
humans
Human Factor Issues of CDS
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Issues
âĒ CDSS asa supplement or replacement of clinicians?
â The demise of the âGreek Oracleâ model (Miller & Masarie, 1990)
The âGreek Oracleâ Model
The âFundamental Theoremâ
Friedman (2009)
Human Factor Issues of CDS
Wrong Assumption
Correct Assumption
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âĒ Features withimproved clinical practice
(Kawamoto et al., 2005)
â Automatic provision of decision support as part of
clinician workflow
â Provision of recommendations rather than just
assessments
â Provision of decision support at the time and location of
decision making
â Computer based decision support
âĒ Usability & impact on productivity
Human Factor Issues of CDS
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âĒ Liabilities
â Cliniciansas âlearned intermediariesâ
âĒ Prohibition of certain transactions vs.
Professional autonomy
(see Strom et al., 2010)
Ethical-Legal Issues of CDS
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âĒ âUnanticipated andunwanted effect of
health IT implementationâ
(www.ucguide.org)
âĒ Resources
â www.ucguide.org
â Ash et al. (2004)
â Campbell et al. (2006)
â Koppel et al. (2005)
Unintended Consequences of
CDS & Health IT
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Ash et al.(2004)
Unintended Consequences of
CDS & Health IT
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âĒ Errors inthe process of entering and
retrieving information
â A human-computer interface that is not
suitable for a highly interruptive use context
â Causing cognitive overload by
overemphasizing structured and âcompleteâ
information entry or retrieval
âĒ Structure
âĒ Fragmentation
âĒ Overcompleteness
Ash et al. (2004)
Unintended Consequences of
CDS & Health IT
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âĒ Errors incommunication & coordination
â Misrepresenting collective, interactive work as
a linear, clearcut, and predictable workflow
âĒ Inflexibility
âĒ Urgency
âĒ Workarounds
âĒ Transfers of patients
â Misrepresenting communication as information
transfer
âĒ Loss of communication
âĒ Loss of feedback
âĒ Decision support overload
âĒ Catching errors
Ash et al. (2004)
Unintended Consequences of
CDS & Health IT
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âĒ Which typeof CDS should be chosen?
âĒ What algorithms should be used?
âĒ How to ârepresentâ knowledge in the system?
âĒ How to update/maintain knowledge base in
the system?
âĒ How to standardize data/knowledge?
âĒ How to implement CDS with good system
performance?
Technical Issues of CDS
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âĒ Choosing theright CDSS strategies
âĒ Expertise required for proper CDSS design &
implementation
âĒ Everybody agreeing on the ârulesâ to be enforced
âĒ Evaluation of effectiveness
Other Issues
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âĒ Speed isEverything
âĒ Anticipate Needs and Deliver in Real Time
âĒ Fit into the Userâs Workflow
âĒ Little Things (like Usability) Can Make a Big Difference
âĒ Recognize that Physicians Will Strongly Resist Stopping
âĒ Changing Direction Is Easier than Stopping
âĒ Simple Interventions Work Best
âĒ Ask for Additional Information Only When You Really Need It
âĒ Monitor Impact, Get Feedback, and Respond
âĒ Manage and Maintain Your Knowledge-based Systems
Bates et al. (2003)
âTen Commandmentsâ for
Effective CDS
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âĒ There areseveral decisions made in a clinical
patient care process
âĒ Data leads to information, knowledge, and
ultimately, decision & actions
âĒ Human clinicians are not perfect and can make
mistakes
âĒ A clinical decision support systems (CDS) provides
support for clinical decision making (to prevent
mistakes & provide best patient care)
âĒ A CDS can be computer-based or paper-based
Key Points
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âĒ CDS comesin various forms, designs, and
architecture
âĒ There are many issues related to design,
implementation and use of CDS
â Technical Issues
â Human Factor Issues
â Ethical-Legal Issues
Key Points
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âĒ Current mindset:CDS should be used to
help, not replace, human providers
âĒ Be attentive to workarounds, alert fatigues,
and other unintended consequences of CDS
â They can cause more danger to patients!!
â They may lead users to abandon using CDS (a
failure)
âĒ There are recommendations on how to best
design & implement CDS
Key Points
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References
âĒ Ash JS,Berg M, Coiera E. Some unintended consequences of information
technology in health care: the nature of patient care information system-related
errors. J Am Med Inform Assoc. 2004 Mar-Apr;11(2):104-12.
âĒ Ariely D. Predictably irrational: the hidden forces that shape our decisions. New
York City (NY): HarperCollins; 2008. 304 p.
âĒ Bates DW, Kuperman GJ, Wang S, Gandhi T, Kittler A, Volk L, Spurr C, Khorasani R,
Tanasijevic M, Middleton B. Ten commandments for effective clinical decision
support: making the practice of evidence-based medicine a reality. J Am Med
Inform Assoc. 2003 Nov-Dec;10(6):523-30.
âĒ Campbell EM, Sittig DF, Ash JS, Guappone KP, Dykstra RH. Types of unintended
consequences related to computerized provider order entry. J Am Med Inform
Assoc. 2006 Sep-Oct;13(5):547-56.
âĒ Elson RB, Faughnan JG, Connelly DP. An industrial process view of information
delivery to support clinical decision making: implications for systems design
and process measures. J Am Med Inform Assoc. 1997 Jul-Aug;4(4):266-78.
âĒ Friedman CP. A "fundamental theorem" of biomedical informatics. J Am Med
Inform Assoc. 2009 Apr;16(2):169-170.
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References
âĒ Greenes RA.Clinical decision support: the road ahead. Oxford (UK): Elsevier;
2007. 581 p.
âĒ Institute of Medicine, Committee on Quality of Health Care in America. To err is
human: building a safer health system. Kohn LT, Corrigan JM, Donaldson MS,
editors. Washington, DC: National Academy Press; 2000. 287 p.
âĒ Kawamoto K, Houlihan CA, Balas EA, Lobach DF. Improving clinical practice
using clinical decision support systems: a systematic review of trials to
identify features critical to success. BMJ. 2005 Apr 2;330(7494):765.
âĒ Koppel R, Metlay JP, Cohen A, Abaluck B, Localio AR, Kimmel SE, et al. Role of
computerized physician order entry systems in facilitating medication errors.
JAMA. 2005 Mar 9;293(10):1197-1203.
âĒ Miller RA, Masarie FE. The demise of the "Greek Oracle" model for medical
diagnostic systems. Methods Inf Med. 1990 Jan;29(1):1-2.
âĒ Osheroff JA, Teich JM, Levick D, Saldana L, Velasco FT, Sittig DF, Rogers KM,
Jenders RA. Improving outcomes with clinical decision support: an
implementerâs guide. 2nd ed. Chicago (IL): Healthcare Information and
Management Systems Society; 2012. 323 p.
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References
âĒ Shortliffe EH.Computer-based medical consultations: MYCIN. New York (NY):
Elsevier; 1976. 264 p.
âĒ Strom BL, Schinnar R, Aberra F, Bilker W, Hennessy S, Leonard CE, Pifer E.
Unintended effects of a computerized physician order entry nearly hard-stop
alert to prevent a drug interaction: a randomized controlled trial. Arch Intern
Med. 2010 Sep 27;170(17):1578-83.