This document discusses the clinical implications of growth and development. It notes that growth occurs in spurts, with the largest increases seen at ages 3, 6-7, and 11-12 in females and 7-9 and 14-15 in males. The timing of orthodontic treatment should consider a patient's growth stage. Arch expansion works best during growth spurts. Growth direction can change or be changed by appliances, and rotation affects overbite development and treatment timing. Understanding growth patterns informs orthodontic treatment planning.