Chapter 10 of 'Practical Malware Analysis' focuses on kernel debugging using WinDbg, emphasizing its use for analyzing device drivers and rootkits in both user and kernel modes. The chapter explains the complexity of drivers, their interaction with the Windows kernel, and provides instructions for setting up kernel debugging and utilizing various WinDbg commands for malware analysis. It also discusses rootkit behavior, particularly how they conceal themselves within the kernel, and techniques for identifying malicious activities and modifications to the kernel environment.