This document discusses how to transform data into information and evidence to inform health policy and programming. It emphasizes that data analysis and interpretation, as well as effective communication and dissemination, are key steps to knowledge brokering. Different types of evidence are needed for various users and purposes. Comparisons of data over time, between groups, and with benchmarks can help turn data into useful information. Communicating evidence in a timely, relevant, and easy to understand way is important to inform decision-making and improve health outcomes. Knowledge management strategies can help strengthen the flow of data and information between producers and end users.