Cori's cycle

Cori's cycle

• 1.
  Cori Cycle [Flowchart]
• 2.
  www.medicoapps.org Cori cycle (Lacticacid cycle) Glucose Glucose 2- Pyruvate 2- Lactate2- Lactate2- Lactate 2- Pyruvate Glucose Gluconeogenesis Glycolysis 6 ATP 2 ATP Blood Muscle Liver In normal state, muscular activities require ATP, from glucose converted to pyruvate (NAD+ NADH) In low O2 state, as in intensive exerciseor hypoxic condition- moreATPs requires Glycogen Glycogenolysis NADHNAD+ LDH Anerobic metabolism Lactic acid fermentation NADH NAD+
• 3.
  www.medicoapps.org Significance Cori cycle prevents,lactate accumulation in the muscles Cori cycle is important in producing ATP in low oxygen conditions. Cori cycle takes place in liver, blood and muscle Cori cycle utilizes, lactate from muscle for gluconeogenesis. Cori cycle is pathway that links anaerobic glycolysis in the muscle to gluconeogenesis in the liver
• 4.
  www.medicoapps.org Exam points Cori cycleis also called as lactic acid cycle or glucose – lactate cycle Cori cycle occurs in muscle, blood and liver. Pyruvate is converted to lactate in the presence of lactate dehydrogenase enzyme Cori cycle gains 2 ATP and loss of 6 ATP Glucose cannot be synthesized in muscle because there are no gluconeogenesis enzymes Cori cycle is pathway that links anaerobic glycolysis in the muscle to gluconeogenesis in the liver
• 5.
  www.medicoapps.org Brain Teaser Cori cycletakes place in muscle, blood and liver!! TRUE/ FALSE??