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CXL presentation.pptx
- 1. Corneal Collagen cross linking(CXL) ALYAN ALI MUHAMMAD USMAN AROOBA MANAHYL SAVIRA KHAN
- 2. History The techniquewas first developed in German in 1997 by Eberhard and this teams
- 3. Introduction Cross-Linking forKeratoconus is a procedure which uses a combination of riboflavin eye drops (i.e. a type of vitamin B) and ultraviolet (UV) light to help strengthen the cornea from further weakening
- 4. Basic components Themain components of CXL are a photosensitizer, a UV light source, and the resulting photochemical reaction Photosenitizer : photosenitizer are molecules which absorbs Light energy and produce chemical energy and others molocules. It safe Systemically & can be adequately absorbed by the corneal stroma typically . Absorption peak 370nm
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- 6. Surgical technique Thestandard treatment protocol, called the Dresden protoco was formulated by Wollensak et al. for corneas with minimal thickness of 400µm, and is as follows: Instill topical anesthetic drops in the eye Debride the central 7-9mm of corneal epithelium Instill 0.1% riboflavin 5-phosphate drops and 20% dextran solution every 5 minutes for 30 minutes Exposure to UVA (370nm, 3mw/cm2) for 30 minutes while continuing instilling the above drops every 5minutes. At the end of the procedure, apply topical antibiotics and soft BCL with good oxygen permeability.
- 7. Adverse effects Themost common side effect are haziness of cornea,punctate Keratitis,corneal striae,corneal epithilium defect & eye pain Those Who use after post Lasik ectasia, most common side effects are haziness of corneal,dye eye,eye pain & sensitive to bright light.