The paper discusses strategies for designing nearly zero-energy buildings (NZEB) to meet European Union targets for reducing greenhouse gas emissions by 2050. It examines various construction technologies and energy production systems aimed at enhancing the energy performance of residential buildings, and presents a case study of a multi-storey residential building in Sicily. Economic feasibility, energy efficiency, and design solutions such as insulation, low-emissivity windows, and green roofs are highlighted as essential components for achieving NZEB standards.