Endocrine and
Metabolic Disorders
Types of Diabetes
 Type 1- Insulin deficient, juvenile diabetes
Types of Diabetes
 Type 2- insulin resistance; adult onset;
Types of Diabetes
 Gestational diabetes- BMI >30, history of GDM
Diagnosis of Diabetes
A1C- measures your average blood glucose for the past 2
to 3 months.
Diagnosis of Diabetes
 Fasting Plasma Glucose (FPG)
Diagnosis of Diabetes
 Oral Glucose Tolerance Test (also called the OGTT)
Diagnosis of Diabetes
 Random (also called Casual) Plasma Glucose Test
 Blood glucose of greater than or equal to
200 mg/dl
Diagnosis of Diabetes
 GDM- new recommendation for OGT 24-28 weeks
 1st- 50 g OGT non-fasting measure glucose 1hour after
and if its greater than 140, you have to proceed to step
2.
 Step 2- different day for fasting. 100 g OGT and will
wait 3 hours. If after 3 hours the BG is greater than 140
then you’re diagnose with GDM.
Goals for all diabetes
 Maintain Blood glucose level
 Consistent carbohydrate intake
 Monitor Blood glucose
 Planned exercise
 Endurance Athletes: 120-180 mg/dl is the blood glucose
range guideline during activity
Glycemic Index
 GI of a food based on the blood glucose response
compared to a reference food
 High GI Foods - Glucose, bread, potatoes, breakfast
cereal, sports drinks
 Medium GI Foods- Sucrose, soft drinks, oats, tropical
fruits
 Low GI Foods- Fructose, milk, yogurt, ice cream
lentils, pasta, nuts, apples, oranges
Food List
 Starch Group (measured after cooking)
1 slice of bread
1/4 large bagel
1/2 hamburger bun, hot-dog bun, pita bread, English muffin
1/3 cup rice, pasta, millet, couscous
1/2 cup beans
1/2 cup starchy vegetable
1/2 cup oatmeal, kasha, grits, bulgur
1 small tortilla (flour or corn, 6 inch size)
6 saltine crackers
3 graham cracker squares
3 cups popcorn
Food List & Carb counting
Fruit Group
 1 small apple, orange, peach, pear, or nectarine
 1 small banana
 1/2 grapefruit
1/2 cup unsweetened applesauce
 3/4 cup fresh pineapple chunks, blueberries, or blackberries
 17 grapes
 1 cup cantaloupe, honeydew, or papaya
1 large kiwi
2 tablespoons raisins
1/2 cup orange juice, apple juice, or grapefruit juice
Food List & Carb counting
 Milk Group
 1 cup of milk
1 cup of soy milk
1 cup of buttermilk
2/3 cup of plain yogurt
2/3 cup of aspartame sweetened yogurt
Medication
 Meglitinieds (Glucotrol), Sulfonylureas: Increase
insulin release from the pancreas
 Metformin: Enhace insulin reaction
 Thiazolidinediones- insulin sensitizers
 Starch blockers (Acarbose) delaying carbohydrate
absorption
 Glucagon like peptide- enhance insulin secretion
 Amylin Agonist
Dawn Phenomenon &
Somogyi effect
 a surge of hormones that the body produces daily
around 4:00 a.m. to 5:00 a.m.
 two phenomena of morning hyperglycaemia
 Dawn phenomenon occurs when endogenous insulin
secretion decrease
 Somogyi effect is present in the case of excessive
amounts of exogenous insulin.
Complications of uncontrolled
diabetes
 Diabetic ketoacidosis (DKA)- hyperglycemia
Signs
 nausea and vomiting
 stomach pain
 dehydration
 fruity breath odor
 rapid breathing
Treatment
 Insulin, rehydration
Complications of uncontrolled
diabetes
 Acute Hypoglycemia- lack of insulin
Symptoms
 Shaking, sweating, rapid heartbeat
 Change in vision
 Hunger
 Headache
 Sudden moodiness
Treatment
 15 g CHO
 Check your blood sugar again after 10-15 minutes.
 Repeat a dose of fast-acting carbohydrates if the sugar is
still low <70 mg/dl. give another 15 g Carb
Complications of uncontrolled
diabetes
 Long Term
Types of Insulin
Fast-acting insulin
 Rapid Acting Insulin Analogs
 Regular Human Insulin (Insulin Aspart, insulin Lyspro, Insulin Glulisine)
ONSET PEAK DURATION
5-15 Minutes 1-2 hours 4-6 hours
ONSET PEAK DURATION
30-60 minutes 2-4 hours 6-8 hours
Types of Insulin
 Intermediate-acting insulin
NPH Human Insulin, Pre-Mixed Insulin
 Long-acting insulin
Insulin Glargine, Insulin Detemir
ONSET PEAK DURATION
1-2 hours 4-6 hours 12 hours
ONSET PEAK DURATION
1 1/2 -2 hours No peak 24 hours

Diabetes

  • 1.
  • 2.
    Types of Diabetes Type 1- Insulin deficient, juvenile diabetes
  • 3.
    Types of Diabetes Type 2- insulin resistance; adult onset;
  • 4.
    Types of Diabetes Gestational diabetes- BMI >30, history of GDM
  • 5.
    Diagnosis of Diabetes A1C-measures your average blood glucose for the past 2 to 3 months.
  • 6.
    Diagnosis of Diabetes Fasting Plasma Glucose (FPG)
  • 7.
    Diagnosis of Diabetes Oral Glucose Tolerance Test (also called the OGTT)
  • 8.
    Diagnosis of Diabetes Random (also called Casual) Plasma Glucose Test  Blood glucose of greater than or equal to 200 mg/dl
  • 9.
    Diagnosis of Diabetes GDM- new recommendation for OGT 24-28 weeks  1st- 50 g OGT non-fasting measure glucose 1hour after and if its greater than 140, you have to proceed to step 2.  Step 2- different day for fasting. 100 g OGT and will wait 3 hours. If after 3 hours the BG is greater than 140 then you’re diagnose with GDM.
  • 10.
    Goals for alldiabetes  Maintain Blood glucose level  Consistent carbohydrate intake  Monitor Blood glucose  Planned exercise  Endurance Athletes: 120-180 mg/dl is the blood glucose range guideline during activity
  • 11.
    Glycemic Index  GIof a food based on the blood glucose response compared to a reference food  High GI Foods - Glucose, bread, potatoes, breakfast cereal, sports drinks  Medium GI Foods- Sucrose, soft drinks, oats, tropical fruits  Low GI Foods- Fructose, milk, yogurt, ice cream lentils, pasta, nuts, apples, oranges
  • 12.
    Food List  StarchGroup (measured after cooking) 1 slice of bread 1/4 large bagel 1/2 hamburger bun, hot-dog bun, pita bread, English muffin 1/3 cup rice, pasta, millet, couscous 1/2 cup beans 1/2 cup starchy vegetable 1/2 cup oatmeal, kasha, grits, bulgur 1 small tortilla (flour or corn, 6 inch size) 6 saltine crackers 3 graham cracker squares 3 cups popcorn
  • 13.
    Food List &Carb counting Fruit Group  1 small apple, orange, peach, pear, or nectarine  1 small banana  1/2 grapefruit 1/2 cup unsweetened applesauce  3/4 cup fresh pineapple chunks, blueberries, or blackberries  17 grapes  1 cup cantaloupe, honeydew, or papaya 1 large kiwi 2 tablespoons raisins 1/2 cup orange juice, apple juice, or grapefruit juice
  • 14.
    Food List &Carb counting  Milk Group  1 cup of milk 1 cup of soy milk 1 cup of buttermilk 2/3 cup of plain yogurt 2/3 cup of aspartame sweetened yogurt
  • 15.
    Medication  Meglitinieds (Glucotrol),Sulfonylureas: Increase insulin release from the pancreas  Metformin: Enhace insulin reaction  Thiazolidinediones- insulin sensitizers  Starch blockers (Acarbose) delaying carbohydrate absorption  Glucagon like peptide- enhance insulin secretion  Amylin Agonist
  • 16.
    Dawn Phenomenon & Somogyieffect  a surge of hormones that the body produces daily around 4:00 a.m. to 5:00 a.m.  two phenomena of morning hyperglycaemia  Dawn phenomenon occurs when endogenous insulin secretion decrease  Somogyi effect is present in the case of excessive amounts of exogenous insulin.
  • 17.
    Complications of uncontrolled diabetes Diabetic ketoacidosis (DKA)- hyperglycemia Signs  nausea and vomiting  stomach pain  dehydration  fruity breath odor  rapid breathing Treatment  Insulin, rehydration
  • 18.
    Complications of uncontrolled diabetes Acute Hypoglycemia- lack of insulin Symptoms  Shaking, sweating, rapid heartbeat  Change in vision  Hunger  Headache  Sudden moodiness Treatment  15 g CHO  Check your blood sugar again after 10-15 minutes.  Repeat a dose of fast-acting carbohydrates if the sugar is still low <70 mg/dl. give another 15 g Carb
  • 19.
  • 20.
    Types of Insulin Fast-actinginsulin  Rapid Acting Insulin Analogs  Regular Human Insulin (Insulin Aspart, insulin Lyspro, Insulin Glulisine) ONSET PEAK DURATION 5-15 Minutes 1-2 hours 4-6 hours ONSET PEAK DURATION 30-60 minutes 2-4 hours 6-8 hours
  • 21.
    Types of Insulin Intermediate-acting insulin NPH Human Insulin, Pre-Mixed Insulin  Long-acting insulin Insulin Glargine, Insulin Detemir ONSET PEAK DURATION 1-2 hours 4-6 hours 12 hours ONSET PEAK DURATION 1 1/2 -2 hours No peak 24 hours

Editor's Notes

  • #3 when the body loses the ability to make insulin or can only make a very small amount of insulin. Type 1 diabetes is usually caused by an autoimmune process, and your body’s immune system mistakenly destroys the insulin-producing cells. About 10% of individuals with diabetes have type 1 diabetes.
  • #4 few things can be happening with this px They may have the “run away liver” is that the px liver is continue to produce sugar. Even eating breakfast. Lunch, dinner during those times, the liver still decides to produce sugar where as for the healthy person who don’t have diabetes the liver typically produce sugar in their blood stream at times when sugar levels were low. The “pooped out pancreas” which means that the patient has a functioning pancreas but a tired pancreas and results to not producing enough insulin to keep up Insulin resistance- a px has enough insulin in the blood stream but the insulin coupled with the sugar is not getting into the cells and so its staying in the blood stream and being passed in the urine
  • #5 When you have gestational diabetes, your pancreas works overtime to produce insulin, but the insulin does not lower your blood glucose levels. Although insulin does not cross the placenta, glucose and other nutrients do. So extra blood glucose goes through the placenta, giving the baby high blood glucose levels. This causes the baby's pancreas to make extra insulin to get rid of the blood glucose. Since the baby is getting more energy than it needs to grow and develop, the extra energy is stored as fat. This can lead to macrosomia, or a "fat" baby. Babies with macrosomia face health problems of their own, including damage to their shoulders during birth. Because of the extra insulin made by the baby's pancreas, newborns may have very low blood glucose levels at birth and are also at higher risk for breathing problems. Babies with excess insulin become children who are at risk for obesity and adults who are at risk for type 2 diabetes.
  • #6 The advantages of being diagnosed this way are that you don't have to fast or drink anything. Diabetes is diagnosed at an A1C of greater than or equal to 6.5%
  • #7 This test checks your fasting blood glucose levels. Fasting means after not having anything to eat or drink (except water) for at least 8 hours before the test. This test is usually done first thing in the morning, before breakfast. Diabetes is diagnosed at fasting blood glucose of greater than or equal to 126 mg/dl -
  • #9 This test is a blood check at any time of the day when you have severe diabetes symptoms. Diabetes is diagnosed at blood glucose of greater than or equal to 200 mg/dl
  • #11 Maintain Blood glucose level Consistent carbohydrate intake Monitor Blood glucose Planned exercise- reduction of insulin dosage to prevent hypoglycemia Endurance Athletes: 120-180 mg/dl is guideline during activity (thletes should drink noncarbohydrate fluids when blood glucose levels exceed the renal glucose threshold (180 mg/ dL, or 10 mmol/L), which may lead to increased urination, fluid loss, and dehydration.)
  • #12 GI of a food reflects the rate of digestion & absorption
  • #13 1 slice of bread (weighing 1 ounce) 1/4 large bagel 1/2 hamburger bun, hot-dog bun, pita bread, English muffin 1/3 cup rice, pasta, millet, couscous 1/2 cup beans (pinto, kidney, garbanzo, lentils) 1/2 cup starchy vegetable (potato, corn, peas, sweet potato, yam) 1/2 cup oatmeal, kasha, grits, bulgur 1 small tortilla (flour or corn, 6 inch size) 6 saltine crackers 3 graham cracker squares 3 cups popcorn
  • #14 1 small apple, orange, peach, pear, or nectarine (1/2 if large fruit) 1 small banana (1/2 of average banana) 1/2 grapefruit 1/2 cup unsweetened applesauce 3/4 cup fresh pineapple chunks, blueberries, or blackberries 17 grapes 3 prunes 1 1/4 cups strawberries, or watermelon 1 cup cantaloupe, honeydew, or papaya 1 large kiwi 2 tablespoons raisins 1/2 cup orange juice, apple juice, or grapefruit juice
  • #15 1 cup = 8 fluid ounces
  • #16 Meglitinides, Sulfonylureas: - Pills that increase insulin release from the pancreas Metformin: Enhace insulin reaction basically it a Pills that reduce sugar production from the liver Thiazolidinediones work to lower your blood sugar by increasing the muscle, fat and liver’s sensitivity to insulin. TZDs are referred to as “insulin sensitizers” and also are blood sugar normalizing Starch blockers (Acarbose) lowers your blood sugar by delaying how quickly starch and carbohydrate (CHO) are absorbed from your intestines. Glucagon like peptide- enhance insulin secretion Pramlintide (amylin agonist)is an injected medicine for people with type 1 and type 2 diabetes that helps control blood sugar levels after eating.
  • #17  The dawn phenomenon is more common than the Somogyi effect. To diagnose these phenomena, it is useful to measure plasma glucose levels for several nights between 3 a.m. and 5 a.m. or use a continuous glucose monitoring system. Although their treatment differs, the best way of preventing both the dawn phenomenon and the Somogyi effect is an optimal diabetes control with insulin therapy. All people have the “dawn phenomenon,” if they have diabetes or not. The dawn phenomenon is a surge of hormones that the body produces daily around 4:00 a.m. to 5:00 a.m. People with diabetes don't have normal insulin responses to adjust for this, and may see their fasting glucose go up. The rise in glucose is mostly because your body is making less insulin and more glucagon (a hormone that increases blood glucose) than it needs. The less insulin made by the pancreas, the more glucagon the pancreas makes as a result. Glucagon signals the liver to break down glycogen into glucose. This is why high fasting blood glucose levels are common in people with type 2. Steps that may help: Eat dinner earlier in the evening Do something active after dinner (such as going for a walk) If your fasting glucose continues to be high, your health care provider may prescribe medication.
  • #18 an emergency condition in which extremely high blood glucose levels, along with a severe lack of insulin, result in the breakdown of body fat for energy and an accumulation of ketones in the blood and urine. Signs of DKA are nausea and vomiting, stomach pain, fruity breath odor and rapid breathing. Untreated DKA can lead to coma and death.
  • #19 As the term implies, low blood sugar, or hypoglycemia, occurs when your brain and body are not getting enough sugar. For most people whose blood sugar is kept in the near normal range, less than 70 mg/dl can be considered low, or hypoglycemic. Treatment Take at least ½ cup fruit juice, or 3 glucose tablets, or approximately 15 grams of glucose or sugar if your blood sugar is low. You will need more glucose if the blood sugar is very low
  • #20 Vision loss or blindness Kidney damage or failure Nerve pain and damage Heart and blood vessel disease High blood pressure Dental problems Hand problems Foot problems
  • #21 Is absorbed quickly from your fat tissue (subcutaneous) into the bloodstream. Is used to control the blood sugar during meals and snacks and to correct high blood sugars
  • #22 Intermediate-acting insulin: Is absorbed more slowly, and lasts longer Is used to control the blood sugar overnight, while fasting and between meals