This document discusses the differential diagnosis of periapical radiolucencies. It describes true periapical radiolucencies such as pulpo-periapical radiolucencies, dentigerous cysts, periapical cemento-osseous dysplasias and malignant tumors. It also discusses pseudo-periapical radiolucencies caused by anatomical variations. Different pathological conditions are described including their etiology, clinical features, radiographic features, differential diagnosis and management.