Dr. Steve Solomon - Metrics and Decision-Making for Antibiotic Stewardship in Human Medicine

Steve Solomon, MD
Director, Office of Antimicrobial
Resistance
Centers for Disease Control and
Prevention
Metrics and Decision-Making for
Antibiotic Stewardship in Human
Medicine
Antibiotic Use and
Resistance: Moving Forward
Through Shared Stewardship
November 12-14, 2014
Atlanta, GA

Key points
 Why measure?
 What to measure?
 How to measure?

Why measure?
 What gets measured gets done.

Antibiotic use is common in
healthcare

Antibiotic prescriptions per 1000 persons of all
ages according to state
Hicks LA et al. N Engl J Med 2013;368:1461-1462.

Why Measure--
Goals and Objectives of Antibiotic Stewardship
 Goals
 Improved population health
 Optimal prescribing of antibiotics
 Sustainable changes in clinical practice
 Objectives
 Better clinical outcomes
 Reduction in antibiotic resistant infections
 Economic benefit

What to measure
 Outcome measures
 Process measures

Outcome measures
• Better clinical outcomes
• Decreased morbidity, mortality overall
• Fewer adverse events (C. difficile infections, adverse drug
reactions, drug-drug interactions)
• Reduction in antibiotic resistance
• Fewer resistant infections
• Less spread of resistant bacteria
• Economic benefit
• Lower healthcare costs for infections and complications
• Reduced pharmacy and consumer costs for antibiotics

Estimated burden of
healthcare-associated CDI
400,000
350,000
300,000
250,000
200,000
150,000
100,000
50,000
0
1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008
• Hospital-acquired, hospital-onset:
165,000 cases, $1.3
billion in excess costs, and
9,000 deaths annually
• Hospital-acquired, post-discharge
(up to 4 weeks):
50,000 cases, $0.3 billion in
excess costs, and 3,000 deaths
annually
• Nursing home-onset: 263,000
cases, $2.2 billion in excess
costs, and 16,500 deaths
annually Year
Number of hospital discharges
Any listed
Primary

Poor Prescribing Harms Patients
 Decreasing the use of antibiotics
that most often lead to C.difficile
infection by 30% could lead to 26%
fewer of these infections
 Patients getting broad-spectrum
antibiotics are up to 3x more likely
to get another infection from an
even more resistant germ

Clinical outcomes better with
antimicrobial management program
100
90
80
70
60
50
40
30
20
10
0
AMP
UP
Appropriate Cure Failure
RR 2.8 (2.1-3.8) RR 1.7 (1.3-2.1) RR 0.2 (0.1-0.4)
Percent
AMP = Antibiotic Management Program
Fishman N. Am J Med. 2006;119:S53. UP = Usual Practice

Increased resistance for individual
patients
Pathogen and Antibiotic
Exposure
Increased
Risk
Carbapenem-resistant
Enterobacteriaceae
 Carbapenems
15 fold
ESBL-producing organisms
 Cephalosporins
6 - 29 fold
Costelloe C et al. BMJ. 2010;340:c2096.
Patel G et al. Infect Control Hosp Epidemiol 2008;29:1099-1106
Zaoutis TE et al. Pediatrics 2005;114:942-9
Talon D et al. Clin Microbiol Infect 2000;6:376-84

Increased resistance in facilities--
resistance in P. aeruginosa vs.
carbapenem use rate
80
70
60
50
40
30
20
10
0
r = 0.41, p = .004
(Pearson correlation coefficient)
0 20 40 60 80 100
% Imipenem-resistant
P. aeruginosa
Carbapenem Use Rate
45 LTACHs, 2002-03 (59 LTACH years) Gould et al. ICHE 2006;27:923-5

Rates of antibiotic resistant organism
infections per 100 intensive care unit, with and
without intervention
Raymond et al. Impact of a rotating empiric antibiotic schedule on infectious mortality in an
intensive care unit. Critical Care Medicine 2001;29:1101

Improving antibiotic use saves
money
• “Comprehensive programs have consistently
demonstrated a decrease in antimicrobial
use with annual savings of $200,000 -
$900,000”
IDSA/SHEA Guidelines for Antimicrobial Stewardship Programs,
http://www.journals.uchicago.edu/doi/pdf/10.1086/510393

Process measures
• Facility stewardship programs
• Optimal prescribing
• Rates of use

http://www.cdc.gov/getsmart/healthcare/implementation/core-elements.html

Process Measures
 Components of the program
 Leadership commitment
 Accountability
 Drug expertise
 Action
 Tracking
 Reporting
 Education

Prescribing Practices Vary
 More than half of all hospital
patients receive an antibiotic
 Doctors in some hospitals
prescribed 3 times as many
antibiotics as doctors in other
hospitals

Optimal prescribing
 Steps in the prescribing process
 Indication for prescription
 Appropriateness
• Consistent with guidelines/best practice
 De-escalation/antibiotic time out
• Change of therapy as indicated to a different antibiotic or IV to PO
 Laboratory confirmation/review

How to measure
 Healthcare clinical and administrative data
 Provider/prescriber-specific
 Facility-specific
 Aggregate—facilities, regions, national
 Outcomes
 Patient outcomes
 Laboratory data
 Cost data
 Process
 Antibiotic use data--benchmarking and tracking
 Practice data, clinical decision support
 Program components

Measuring Antibiotic Use
 Assessments of aggregate use
 Proprietary data
 Facility-specific antibiotic administration data
 Electronic records
 Detailed assessments of appropriate antibiotic use
 Antibiotic use assessment

Mock-up: Risk-adjusted Benchmarking of
Antimicrobial Use To Guide Stewardship
Antimicrobial Class-Specific Usage Rates
and Standardized Utilization Ratios (SURs)
ABX Days
Observed Predicted SUR* Interpretation
MICU 4000 1000 4.0 Excessive
SICU 2000 2000 1.0 Consistent
Medical Ward 3000 4000 0.75 Lower Use
Surgical Ward 1000 3000 0.33 Much Lower
Hospital 170,250 171,000 0.99 Consistent
*SUR=ratio of the observed vs. predicted usage for the patient population defined
by the location (e.g., MICU , SICU, etc)

http://www.cdph.ca.gov/programs/hai/Pages/AntimicrobialStewardshipProgramInitiative.aspx

Complementary measures
 Prescribing
 Objective
 Prospective
 May be more acceptable
 Appropriateness
 Subjective
 Retrospective
 More difficult to interpret

Challenges
 Complexity
 Behavioral, institutional, ecological focus
 Institutional variability
 One size can’t fit all
 Access to and management of data
 Electronic, proprietary, unfiltered
 Analysis of data, risk adjustment
 Where to set the benchmarks

Summary and Conclusions
• Reduction in use is not an end in itself but a natural
outcome of better practices
• Benchmarking is a useful tool, but continuous
quality improvement within each setting is the
process objective
• Optimal prescribing is a key goal to complement
appropriateness of use
• Access to and management of electronic data is a
significant challenge

For more information please contact Centers for Disease Control and
Prevention
1600 Clifton Road NE, Atlanta, GA 30333
Telephone, 1-800-CDC-INFO (232-4636)/TTY: 1-888-232-6348
E-mail: cdcinfo@cdc.gov Web: www.cdc.gov
The findings and conclusions in this report are those of the authors and do not necessarily represent the official
position of the Centers for Disease Control and Prevention.
National Center for Emerging and Zoonotic Infectious Diseases
Division of Healthcare Quality Promotion

Dr. Steve Solomon - Metrics and Decision-Making for Antibiotic Stewardship in Human Medicine

More Related Content

What's hot

Viewers also liked

Similar to Dr. Steve Solomon - Metrics and Decision-Making for Antibiotic Stewardship in Human Medicine

More from John Blue

Recently uploaded

Dr. Steve Solomon - Metrics and Decision-Making for Antibiotic Stewardship in Human Medicine