Emdogain is a gel containing enamel matrix proteins that has been shown to regenerate hard and soft tissues lost to periodontal disease. It works by attracting mesenchymal cells to the root surface, promoting attachment, proliferation, and differentiation which results in new cementum, bone, and periodontal ligament formation. Over 20 years of clinical studies involving over 2 million patients have demonstrated its effectiveness and safety in treating intra-bony and gingival recession defects.