The document provides comprehensive information on endodontic sealers and irrigating solutions, detailing their functions, characteristics, and various types including zinc oxide eugenol, calcium hydroxide, glass ionomer, and resin-based sealers. It discusses the toxicity levels of these materials, their efficacy in microbial control, and the importance of irrigation solutions such as NaOCl, chlorhexidine, and EDTA in root canal therapy. The conclusions highlight that sealers vary in their toxicity and long-term performance, with recommendations for further research into methacrylate-based materials.