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Fat soluble vitamins
This document discusses the fat-soluble vitamins A, D, E, and K. It provides details on their sources, absorption, functions, deficiencies, and toxicity. The key points are: 1) Fat-soluble vitamins are stored in tissues and excess intake can be harmful unlike water-soluble vitamins. 2) Vitamin A supports vision, immune function, and cell growth. Too much can cause birth defects and liver damage. 3) Vitamin D aids calcium absorption and bone formation. The body produces it from sunlight but it is also found in foods. Deficiency causes rickets and osteomalacia. 4) Vitamin E is an antioxidant that protects cells. Def
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Fat soluble vitamins
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- 2. FAT SOLUBLE VITAMINS Fat soluble vitamins have long nonpolar hydrocarbon chains or rings. Common fat soluble vitamins include • A • D • E • K 2 Vitamin D Vitamin K
- 3. FAT SOLUBLE VITAMINS Fat soluble vitamins usually accumulate in tissues and are not leached out quickly. Unlike water soluble vitamins, an excess of a fat soluble vitamin can be just as harmful as a deficiency. 3
- 4. 1. VITAMIN A(RETINOL) Foods from animal source provide various retinoids that are easily converted to retinol in the body Foods from plant source provide carotenoids Over 500 carotenoids found in nature Less than 10% with provitamin A activity -carotene highest activity Must be acted upon in the gut or by the liver to form retinol
- 5. VITAMIN A -SOURCES Animal sources Liver Milk Egg yolk Plant sources Carrots Green leafy vegetables Orange coloured fruits, e.g. mango and apricots
- 6. 6 •RDA (retinol): • 1000 μg of retinol, or 3,500 IU, for males • 800 μg of retinol, or 2,500 IU, for females •one glass of milk provides 10% of the RDA •one medium carrot provides 200% of the RDA •a serving of liver provides 900% of RDA
- 7. THE RETINOIDS 3 forms of vitamin A important for health Retinol (key player; can be converted to other forms) Retinal Retinoic acid β-carotene potent provitamin A
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- 9. CAROTENOID CLEAVAGE ANDSTORAGE β-carotene is converted to vitamin A in the intestinal mucosa 90% is stored in liver, mainly as the ester, retinyl palmitate (~ 6 months storage) Small amounts in adipose and blood Transport Retinol binding protein(RBP) acts to transport vitamin A from the liver and in the blood. Excretion Small amount in urine
- 10. MAJOR FUNCTION INTHE BODY vital to good vision prevents night blindness antioxidant (β-carotene) necessary for healthy skin, hair growth keeps mucous membranes healthy promotes bone development Support immunity (retinoic acid and carotenoids) 10
- 11. Role of vitaminA in vision
- 12. RHODOPSIN CYCLE ORWALD’S VISUAL CYCLE •Rhodopsin: combination of a protein part (opsin) and 11-cis retinal (only cis form can bind with opsin). •When light energy is absorbed by rhodopsin, the rhodopsin decompose: converts 11-cis retinal into all-trans retinal. •In order to maintain the ability to detect light, the rods must reconvert the all-trans retinal into 11-cis retinal. •This process only occurs under the dark environment. •Dark adaptation time
- 13. VITAMIN A - DEFICIENCY More obvious deficiency symptoms than other vitamins Night blindness Leading cause of blindness in third world countries Cell keratinization Dry skin Xerophthalmia (dryness of cornea & conjunctiva) Reproductive failure Abnormal skeletal development/maintenance Immune dysfunction
- 14. VITAMIN A TOXICITY Not readily excreted Hypervitaminosis A in humans Self-medication and overprescription symptom Skeletal malformations, spontaneous fractures Birth defects and miscarriage Decalcification, joint pain, fragility Dry itchy skin Hair loss Liver damage Overconsumption of beta carotene from food sources may cause skin to turn yellow but is not harmful
- 15. BENEFICIAL EFFECTS OFΒ- CAROTENE Antioxidant role of β-carotene Increased consumption of β-carotene is associated with decreased incidence of heart attacks, skin and lung cancers. High doses of carotene for long periods are not toxic.
- 16. 2. VITAMIN D:SUNSHINE VITAMIN Body can make it if exposed to enough sunlight Made from cholesterol in the skin
- 17. VITAMIN D -SOURCES Synthesized in body Plants (ergosterol) Sun-cured forages Fluid milk products are fortified with vitamin D Oily fish Egg yolk Butter Liver Daily Value 10 micrograms
- 18. VITAMIN D (CALCIFEROL) There are 2 major precursor forms: 7-dehydrocholesterol Ergosterol Vitamin D2 = ergocalciferol Completely synthetic form produced by the irradiation of the plant steroid ergosterol Vitamin D3 = cholecalciferol Produced photochemically by the action of sunlight or ultraviolet light from the precursor sterol 7- dehydrocholesterol
- 19. FORMATION OF VITAMIND Skin (UV light) 7-dehydro cholesterol vitamin D3 Liver OH-group added 25-hydroxy vitamin D3 Storage form of vitamin (~3 months storage in liver) Kidney OH-group added by 1-hydroxylase 1,25-dihydroxy vitamin D3 (or 1,25-dihydroxy cholecalciferol, 1,25-DHCC) Active form of vitamin D, a “steroid hormone” OH-group added by 24-hydroxylase 24,25-dihydroxy vitamin D3 Inactive form of vitamin D, ready for excretion
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- 22. Chemical name AbbreviationGeneric name Vitamin D2 D2 Ergocalciferol Vitamin D3 D3 Cholecalciferol 25-hydroxy Vitamin D3 25(OH)D3 Calciferol 1,25-dihydroxy vitamin D3 1,25-(OH)2D3 Calcitriol 24,25-dihydroxy vitamin D3 24,25- (OH)2D3 Secalcifediol
- 23. 23 FUNCTIONS OFVITAMIN D Calcium and Phosphorus Homeostasis Calcium and Phosphorus absorption (small intestine) Calcium resorption (bone and kidney) Maintain blood calcium levels Bone formation Stimulate calcium uptake for deposition as calcium phosphate (Osteoblasts: bone-forming cells) Hormone Regulation of gene expression Cell growth
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- 26. VITAMIN D (ANTIRACHITIC VITAMIN)- DEFICIENCY Less common Young animals Rickets (meaning: twist) Failure of bones to grow properly Results in “bowed” legs or knock-knees, outward bowed chest and knobs on ribs Older animals Osteomalacia(Greek: osteon-bone, malakia-softness): Adult form of rickets Osteoporosis (porous bones): Loss of vitamin D activity with advancing age Associated with fractures very serious for geriatrics
- 27. OSTEOPOROSIS progressive lossof bone density, thinning of bone tissue and increased vulnerability to fractures in the elderly people of both sexes.
- 28. VITAMIN D TOXICITY Hypervitaminosis D Among the vitamins, vitamin D is the most toxic in overdoses(10-100 times RDA) Calcification of soft tissue Lungs, heart, blood vessels Hardening of arteries, stone formation in kidneys Does not occur from sunlight or dietary sources Does occur with supplementation In general, vitamin D supplement are not recommended. Upper limit: 50 micrograms a day
- 29. 3. VITAMIN E(TOCOPHEROL) A naturally occurring antioxidant. Essential for nomal reproduction in many animals. Tocopherol (Greek: tokos-child birth; pheros-bear; ol-alcohol), Anti-sterility vitamin.
- 30. VITAMIN E -SOURCES Plant sources Cereal grains Especially in germ Vegetable and seed oils Animal sources Meat,milk,butter,eggs RDA: 10 mg for men, and 8 mg for women
- 31. VITAMIN E (TOCOPHEROL) The term vitamin E refers to a family of 8 related compounds, the tocopherols and the tocotrienols The four major forms of vitamin E are designated a, , d, g, of which a -tocopherol is the most active. O CH3 H3C HO CH3 CH3 CH3 CH3 CH3 CH3 ALPHA TOCOPHEROL
- 32. 32 ABSORPTION, TRANSPORTAND EXCRETION OF VITAMIN E Absorption and Transportation Micelles into chylomicrons Transported via lipoproteins Stored in adipose tissue Excretion Bile, urine and skin
- 33. MAJOR FUNCTION INTHE BODY Antioxidant Vitamin E is very unstable, easily oxidized protect cells against oxidative damage by free radicals, for example oxidation of the lipids in the cell membranes plays a role in aging, sexual performance, or prevention of cancer and/or heart disease 33
- 37. VITAMIN E -DEFICIENCY Rare Erythrocyte hemolysis and hemolytic anemia disruption of red blood cell membranes, perhaps due to polyunsaturated fatty acids (PUFAs) oxidation Sterility: reproductive failure
- 38. VITAMIN E TOXICITY Toxicity rare: wide range of safe intake compared to other fat soluble vitamins - Vitamin E is one of the most popular nutrient supplements. There are many health claims for supplementation – slowing of the aging process or an improvement in sexual potency.
- 39. 4. VITAMIN K The only fat soluble vitamin with a specific coenzyme function. Required for the production of blood clotting factors, essential for coagulation. Named as antihemorrhagic vitamin.
- 40. VITAMIN K -SOURCES Plant sources Green leafy vegetables Some oils Broccoli Animal sources Liver Milk Also made by bacteria in the gut RDA: 80 μg for men, 65 μg for women
- 41. FORMS OF VITAMINK K1, phylloquinone Chloroplasts in plants K2, menaquinone Bacterial synthesis K3, menadione Synthetic, Complexed to improve stability Vitamin K2
- 42. ABSORPTION, TRANSPORT AND EXCRETION OF VITAMIN K 42 Absorption and Transportation Absorbed in small intestine, via chylomicrons in lymphatic system. Transported via lipoproteins and stored in the liver Excretion Primarily bile, small amount urine
- 43. FUNCTIONS OF VITAMINK Essential for clotting of blood. Clotting factors are synthesized in the liver as inactive precursors - vitamin K converts them to their active forms Conversion of prothrombin to thrombin, an active enzyme Formation of fibrinogen to fibrin, leading to clot formation Stimulates bone formation and decreases bone resorption.
- 44. Gamma carboxylation ofclotting factors II,VII,IX and X produces calcium binding sites
- 46. Deficiency: increasedbleeding and hemorrhage - rare, they may occur in some individuals when antibiotic medications kill the intestinal bacteria that produce the vitamin. Hypervitaminosis K: thrombosis, hemolytic anaemia and jaundice, particularly in infants. The toxic effect is due to increased breakdown of RBC. 46