This document discusses the challenges facing agricultural systems due to climate change, shifting consumption patterns, increasing food and energy prices, and land degradation. It notes the transition from cereals to meat and high-value crops requiring more resources. Smallholder farmers play a central role in driving development but face increasing pressures. There is a need to redefine research agendas to address issues like competition over land and environmental services, economic disparities, and poverty. Approaches should focus on smallholders' innovations, systems thinking, collective action, and multi-level economic and social organizations. Capacity building for innovation is needed at the individual, organizational, partnership, and institutional levels.