Gastric proton pump inhibitors (pp is)

Gastric proton pump inhibitors (pp is)

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  Gastric Proton pumpinhibitors (PPIs) Presented by- Gautam Kumar B. Pharm,5 semester School of Pharmacy
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  Gastric Proton pumpinhibitors (PPIs) • Proton Pump Inhibitors (PPIs) are irreversible inhibitors of gastric parietal cell proton pump. • This enzyme promotes the exchange of H + or K+ ions, which are required for mediating HCl secretion. PPIs induce 80 -90% inhibition of basal, nocturnal, and food stimulated acid levels after single administration. • PPIs reduce the acid production by blocking the enzyme present in the stomach wall. • Reduction in the production of acid by stomach prevents the occurrence of ulcers and also facilitates the healing of ulcers already existing in the oesophagus, stomach, and duodenum.
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  Study of Drugs 1)Omeprazole, 2)Lansoprazole 3) Rabeprazole 4) Pantoprazole.
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  Omeparazole 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)- 1Hbenzimidazole Omeprazole inhibits theproton pump and decreases the amount of acid produced in the stomach Belongs to the class of organic compounds known as sulfinylbenzimidazoles. Stop gastric acid secretion by selective inhibition of the H+/K+ATPase enzyme system. It is used for t reating GERD and other conditions caused by excessive production of stomach acid. It is used to promote the healing of erosive oesophagitis (damage caused to oesophagus by the stomach acid).
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  It is usedto relieve heartburn, difficulty in swallowing, and persistent cough. It is used to prevent oesophageal cancer. It is used along with antibiotics to treat gastric ulcer caused by H. pylori. This Photo by Unknown Author is licensed under CC BY-SA This Photo by Unknown Author is licensed under CC BY-SA This Photo by Unknown Author is licensed under CC BY
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  Lansoprazole 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-1H- benzimidazole • Lansoprazole isa substituted benzimidazole prodrug having the selective and irreversible proton pump inhibitor activity • It prevents the production of acid in the stomach. • Belongs to the class of organic compounds known as sufinylbenzimidazoles. • Lansoprazole is a prodrug and requires protonation via an acidic environment to become activated. • It is used for treating acid -reflux disorders ( like GERD) and peptic ulcer disease. • It is used for H. pylori eradication. • It is used in combination with NSAIDs for preventing gastrointestinal bleeding. This Photo by Unknown Author is licensed under CC BY-SA-NC
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  Rabeprazole 2[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole • Rabeprazole isan antiulcer drug that blocks the H + -K + -ATPase of the coating gastric cells • It also inhibits the dose -dependent oppresses basal and stimulated gastric acid secretion. • Belongs to the class of organic compounds known as sulfinylbenzimidazoles. • It is used in the treatment of Gastroes ophageal reflux disease (GERD) and poorly responsive systemic GERD.
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  • It isused in severe erosive esophagitis. • It is used in pathol ogic hypersecretory conditions, like Zollinger-Ellison syndrome, systemic mastocytosis, and multiple endocrine adenomas • It is used for treating duodenal ulcers with or without anti -infectives for Helicobacter pylori. • It is also used for curing the daytime or night time heartburn. • When studied in vitro,rabeprazole is chemically activated at pH 1.2 with a half – life of 78 second. This Photo by Unknown Author is licensed under CC BY-SA This Photo by Unknown Author is licensed under CC BY-SA
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  • Pantoprazole 5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]-1H-benzimidazole Pantoprazole isa first generation PPI. It is also used for treating other disorders wherein gastric acid secretion needs to be reduced . Pantoprazole is available in many forms , such as a delayed -release oral capsule, oral suspension, and intravenous injection. Belongs to the class of organic compounds known as sulfinylbenzimidazoles. Pantoprazole injection is given t o patients having GERD and history of erosive esophagitis for short -term treatment (7 -10 days) . It is given as an alternate to pantoprazole delayed-release tablets in patients who are not able to swallow the tablets.
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  • It isused in the treatment of pathological hypersecretory conditions related to Zollinger-Ellison syndrome or other neoplastic conditions. • Pantoprazole delayed-release oral suspension is used for short-term treatment of erosive esophagitis related to GERD. • It is also used to promote the healing of erosive esophagitis and decrease the relapse rates of daytime and night time heartburn symptoms in adult patients of GERD. • Due to their good safety profile and as several PPIs are available over the counter without a prescription. This Photo by Unknown Author is licensed under CC BY-SA
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  Medicinal Chemistry- 2,Dr.SelvaKumar.S,Dr.SachinJ.Dighade,Dr.R.Srin ivasan ThakurPublication Pvt.Ltd. Gastric Proton pump inhibitors. Omeprazole,Lansoprazole,Rabeprazole,Pantopr azole. Page45-46,45-49. References
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