Gastro- Retentive Drug Delivery System.pptx

Gastro- Retentive Drug Delivery System.pptx

• 1.
  A SEMINAR ON Topic: Gastro-Retentive Drug Delivery System Presented By: Hariom Jaiswal M. Pharm (Pharmaceutics) 1st Year / 1st Sem (2021-22) INSTTITUTE OF TECHNOLOGY OF MANAGEMENT GIDA, GORAKHAPUR, U.P
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  CONTENTS: 1. INTERODUCTION 2. POTENIALCANDIDATES FOR GRDDs 3. APPROACHES GRDDs 4. ADVANTAGES 5. DISADVANTAGES 6. APPLICATION 7. REFERENCES
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  INTRODUCTION OF GRDDs: •Gastro- retentive drug delivery is an approach to prolong gastric residence time, there by targeting site specific drugs release in upper gastrointestinal tract (GIT) for local or by retaining dosage form into stomach and by releasing the in controller manner . • Oral drug administration has been the predominant route drug delivery. • Gastric residence is time which a drug resides in stomach • Depend upon fluid and food intake. • GRDDs are designed to delay gastric emptying.
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  POTENTIAL CANDIDATES FORGRDDs: • Drugs acting locally in the stomach. • Drugs that are primarily absorbed. • Drugs that is poorly soluble at alkaline pH. • Drugs with a narrow absorption window. • Drugs which are absorbed rapidly form the GI tract. • Drugs that degrade in the colon. • Drugs with less half life. • Drugs that disturb normal colonic microbes.
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  APPROACHES TO GRDDs: A.Lowdensity/ Floating system. B.Bio-adhesive system or Muco-adhesive. C.High density system. D.Swellable system.
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  A. LOW DENSITY/ FLOATING SYSTEM: Floating drug delivery system have a bulk density lower then gastric fluids and thus remain buoyant in the stomach for prolong period time, without affecting the gastric emptying rate. While the system in floating on the gastric contents, the drug is released slowly at a deisred rate form the system . This type is also called as hydro- dynamically balanced system (HBS).
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  MACHANISM OF FDDs: FDDshas a bulk density lees then gastric fluid and remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period time . F = Buoyancy- Gravity = (Df-Ds)gv Where- F = Total vertical force. Df = Fluid density. Ds = Object Density. V = Volume
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  TYPE OF FLOATINGSYSTEM: 1.Effervescent system. 2.Non – effervescent system. 1.Effervescent system: A drug delivery system can be made to float in the stomach by incorporating chamber which may be filled with vacuum , air or inert gas. The gas in floating chamber can be introduced either by volatilization of an organic solvent or by effervescent reaction between organic acids and bicarbonate salt. These effervescent system further classified into two types : a. Volatile liquid or Vacuum containing system . b. Gas generating system.
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  2. Non –effervescent system: It is the FDDS is based on mechanism of swelling of polymer or bio-adhesionto mucosal layer in GI tract . The most commonly used excipient in non- effervescent FDDS are gel forming or highly swellable type hydrocolloids hydrophilic gums and matrix forming such as polycarbonate polyacrylate etc as well as a bio-dhesive polymer such as Carbopol this system can be further divided in to the sub- types: a. Hydrodynamically balanced systems. b. Micro-balloons / Hollow microspheres. B. BIOADHESIVE SYSTEM: Bio/mucoadhesive system are those which bind to the gastric epithelial call surface or mucin and serve as a potential means of extending the Gastro retention of drug delivery system (DDS) in the stomach by increasing the intimacy and duration of contact of drug with the biological membrane.
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  A bio/mucoadhesive substancesis a natural or synthetic polymer capable of producing an adhesive interaction based on hydration mediated , bonding mediated or receptor mediated adhesion with a biological membra lining of GI mucosa. ADVANTAGES OF GRDDs: • Local action. • Improved drug absorption. • Enhanced bio-availabilty. • Controlled drug delivery of drug. • Site specific drug delivery.
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  DISADVANTAGES OF GRDDs: •Drug that cause gastric lesion. • Drug that undergo first pass metabolism. • Drug that have very limited acid solubility and stability. • Drug that degrade in acidic environment. • Requires high levels of fluid in stomach. • Requries presence of blood to delay gastric emptying. APPLICATION: • Enhanced bioavilability. • Sustained drug • delivery system
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  REFERENCES: • https://www.slideshare.net/ShwetaNehate/gastro-retentive- drug-delivery-system-ppt-grdds • https://www.slideshare.net/AnkitMalik60/ankit-gastro- retentive-drug-delivery-system •https://www.slideshare.net/sumelashique/gastro-retentive- drug-delivery-system-by-sumel-ashique