Physiology attempts to explain the physical and chemical factors responsible for life. Homeostasis refers to maintaining equilibrium by balancing internal and external environments. The main body systems that help maintain homeostasis are the respiratory, gastrointestinal, cardiovascular, urinary, endocrine, musculoskeletal, and nervous systems. Body fluid consists of water and dissolved solutes, making up 60% of total body weight, with extracellular fluid comprising 20% and intracellular fluid 40%.