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Grignard reagents
Grignard reagents are organomagnesium compounds formed by the reaction of an organic halide and magnesium. The reaction proceeds through single electron transfers where radicals are converted to carbanions. Grignard reagents are strong nucleophiles similar to organolithium reagents that can form new carbon-carbon bonds. They were analyzed by decomposing ethylmagnesium iodide with sulfuric acid and directing steam through the apparatus to drive off any ethane, proving it did not appreciably dissolve under experimental conditions.
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Overview of Grignard reagents presented by Umang Jagani from CS3 GSFC University.
Describes the mechanism involving single electron transfer and the formation of carbanions.
Illustrates the weak acid and strong base nature of Grignard reagents.
Highlights similarities between Grignard and organolithium reagents as strong nucleophiles.
Details experimental approach using ethylmagnesium iodide and sulfuric acid to analyze gas production.
Concluding slide thanking the audience.
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Grignard reagents
- 1. Grignard Reagents By Umang Jagani (CS3GSFC University)
- 4. Mechanism The reaction proceedsthrough single electron transfer. In the Grignard formation reaction, radicals may be converted into carbanions through a second electron transfer. R−X + Mg → R−X•− + Mg•+ R−X•− → R• + X− R• + Mg•+ → RMg+ RMg+ + X− → RMgX
- 5. Nature of GrignardReagent CH4 CH3 - weak acid strong base
- 6. Grignard reagents aresimilar to organolithium reagents because both are strong nucleophiles that can form new carbon–carbon bonds.
- 8. Gas analysis • Ethylmagnisiumiodide was decomposed by dil sulphuric acid. • A jet of steam was then directed on C to drive over any ethane which may have dissolved in the ether or water layers. • It was also proved that there was no appreciable solution of ethane in the contents of D under experimental conditions.
- 9.